dbPTM

F193A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F193A_HUMAN
UniProt AC	P78312
Protein Name	Protein FAM193A
Gene Name	FAM193A
Organism	Homo sapiens (Human).
Sequence Length	1265
Subcellular Localization
Protein Description
Protein Sequence	MKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQQHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPTQQAEQAPNTCECHVCKQEASGLTPSAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHSKALPPAPVQNHTNKHQVFNASLQDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKNWNPGTFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQDAFMEANKVVMATSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAALSPASTPHLANLAAPSFPKTATTTPGFVDTRKSFCPAPLPPATDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEEQRRREEEEDEEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFLLPKEVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVVDLMSITEQKREERKVNSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDGVSLLLPSLGYNGAILAHCNLRLPGSSDCAASASQVVGITDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQTRQRLSINWSNFSLKKATFAAH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	VRLLRQLSAAAKVKA HHHHHHHHHHHHCCC	13.92	-
14	Ubiquitination	RQLSAAAKVKAPSGL HHHHHHHHCCCCCCC	39.27	29967540
66	Phosphorylation	HLKKFQVTWELHNKH HHHHEEEEEECCCHH	11.48	-
137	Ubiquitination	EEWLECQKRIDAYVD HHHHHHHHHHHHHHC	64.08	-
176	Ubiquitination	IEEQLTNKKAVTGEN HHHHHHCCCCCCCCC	36.55	29967540
177	Ubiquitination	EEQLTNKKAVTGENN HHHHHCCCCCCCCCC	50.59	-
180	Phosphorylation	LTNKKAVTGENNFTD HHCCCCCCCCCCHHH	43.57	29396449
186	Phosphorylation	VTGENNFTDTMRHML CCCCCCHHHHHHHHH	32.46	29396449
188	Phosphorylation	GENNFTDTMRHMLSS CCCCHHHHHHHHHHH	17.04	-
198	Phosphorylation	HMLSSRLSMPDCPNC HHHHHCCCCCCCCCC	27.45	24719451
198 (in isoform 2)	Phosphorylation	-	27.45	24719451
200	Ubiquitination	LSSRLSMPDCPNCNY HHHCCCCCCCCCCCC	36.35	29967540
255	Phosphorylation	PDYLAERSPPSVSSA CCHHHHCCCCCCCCC	32.44	30177828
258	Phosphorylation	LAERSPPSVSSASSG HHHCCCCCCCCCCCC	37.71	28450419
260	Phosphorylation	ERSPPSVSSASSGSG HCCCCCCCCCCCCCC	25.23	28450419
261	Phosphorylation	RSPPSVSSASSGSGS CCCCCCCCCCCCCCC	29.98	30177828
263	Phosphorylation	PPSVSSASSGSGSSS CCCCCCCCCCCCCCC	36.86	28450419
264	Phosphorylation	PSVSSASSGSGSSSP CCCCCCCCCCCCCCC	36.37	28450419
266	Phosphorylation	VSSASSGSGSSSPIT CCCCCCCCCCCCCEE	37.13	28450419
268	Phosphorylation	SASSGSGSSSPITIQ CCCCCCCCCCCEEEE	29.37	28450419
269	Phosphorylation	ASSGSGSSSPITIQQ CCCCCCCCCCEEEEC	43.59	28450419
270	Phosphorylation	SSGSGSSSPITIQQH CCCCCCCCCEEEECC	23.24	28450419
273	Phosphorylation	SGSSSPITIQQHPRL CCCCCCEEEECCCEE	19.00	28450419
283	Phosphorylation	QHPRLILTDSGSAPT CCCEEEEECCCCCCC	22.56	29255136
285	Phosphorylation	PRLILTDSGSAPTFC CEEEEECCCCCCCCC	29.43	29255136
287	Phosphorylation	LILTDSGSAPTFCSD EEEECCCCCCCCCCC	34.72	29255136
290	Phosphorylation	TDSGSAPTFCSDDED ECCCCCCCCCCCCCC	36.67	29255136
293	Phosphorylation	GSAPTFCSDDEDVAP CCCCCCCCCCCCCHH	43.86	29255136
293 (in isoform 2)	Phosphorylation	-	43.86	24719451
302	Phosphorylation	DEDVAPLSAKFADIY CCCCHHCCHHCCCEE	28.49	23898821
343	Phosphorylation	NMALKDESPQISSTS CCCCCCCCCCCCCCC	32.04	22468782
347	Phosphorylation	KDESPQISSTSSSSS CCCCCCCCCCCCCCC	23.47	22468782
348	Phosphorylation	DESPQISSTSSSSSE CCCCCCCCCCCCCCC	33.66	22468782
349	Phosphorylation	ESPQISSTSSSSSEA CCCCCCCCCCCCCCC	26.32	22468782
350	Phosphorylation	SPQISSTSSSSSEAD CCCCCCCCCCCCCCC	30.12	22468782
351	Phosphorylation	PQISSTSSSSSEADD CCCCCCCCCCCCCCH	34.04	22468782
352	Phosphorylation	QISSTSSSSSEADDE CCCCCCCCCCCCCHH	37.34	22468782
353	Phosphorylation	ISSTSSSSSEADDEE CCCCCCCCCCCCHHH	33.86	22468782
354	Phosphorylation	SSTSSSSSEADDEEA CCCCCCCCCCCHHHC	38.46	22468782
381	Phosphorylation	KEDGVLGSRSPRTEE CCCCCCCCCCCCCCC	25.98	23401153
383	Phosphorylation	DGVLGSRSPRTEESK CCCCCCCCCCCCCCC	22.04	25159151
383 (in isoform 2)	Phosphorylation	-	22.04	24719451
386	Phosphorylation	LGSRSPRTEESKADS CCCCCCCCCCCCCCC	47.70	26657352
389	Phosphorylation	RSPRTEESKADSPPP CCCCCCCCCCCCCCC	27.23	23401153
393	Phosphorylation	TEESKADSPPPSYPT CCCCCCCCCCCCCCH	44.13	23401153
397	Phosphorylation	KADSPPPSYPTQQAE CCCCCCCCCCHHHHH	49.90	23927012
398	Phosphorylation	ADSPPPSYPTQQAEQ CCCCCCCCCHHHHHH	18.97	28450419
400	Phosphorylation	SPPPSYPTQQAEQAP CCCCCCCHHHHHHCC	25.69	30108239
409	Phosphorylation	QAEQAPNTCECHVCK HHHHCCCCCEEEECH	14.50	23927012
477	Phosphorylation	PLIHPTLYATPPFTH CCCCCEECCCCCCCC	15.77	27642862
479	Phosphorylation	IHPTLYATPPFTHSK CCCEECCCCCCCCCC	20.24	-
519	Phosphorylation	YPSCFGNTPEWNSSK CHHHCCCCCCCCHHH	23.98	-
527	Phosphorylation	PEWNSSKFISLWGSE CCCCHHHHHHHHCHH	5.05	32142685
533	Phosphorylation	KFISLWGSEVMNDKN HHHHHHCHHHHCCCC	18.55	27251275
584	Phosphorylation	TPAVSDSKEKKNAAK CCCCCCCHHHHHHHH	77.78	32142685
642	Phosphorylation	VSSKRPPSVGDVFHG ECCCCCCCHHHHCCC	41.22	23401153
642 (in isoform 2)	Phosphorylation	-	41.22	24719451
651	Phosphorylation	GDVFHGISKEDHRHS HHHCCCCCCCCCCCC	34.29	23403867
658	O-linked_Glycosylation	SKEDHRHSAPAAPRN CCCCCCCCCCCCCCC	35.58	31492838
658	Phosphorylation	SKEDHRHSAPAAPRN CCCCCCCCCCCCCCC	35.58	27174698
664	Phosphorylation	HSAPAAPRNSPTGLA CCCCCCCCCCCCCCC	52.08	32142685
666	Phosphorylation	APAAPRNSPTGLAPL CCCCCCCCCCCCCCC	25.72	23663014
668	Phosphorylation	AAPRNSPTGLAPLPA CCCCCCCCCCCCCCC	44.65	23663014
677	Phosphorylation	LAPLPALSPAALSPA CCCCCCCCHHHCCHH	18.01	23663014
682	Phosphorylation	ALSPAALSPAALSPA CCCHHHCCHHHCCCC	14.04	25850435
687	Phosphorylation	ALSPAALSPASTPHL HCCHHHCCCCCCCCH	17.44	25850435
690	Phosphorylation	PAALSPASTPHLANL HHHCCCCCCCCHHHH	45.94	25850435
691	Phosphorylation	AALSPASTPHLANLA HHCCCCCCCCHHHHC	19.48	29978859
701	Phosphorylation	LANLAAPSFPKTATT HHHHCCCCCCCCCCC	49.83	29978859
705	O-linked_Glycosylation	AAPSFPKTATTTPGF CCCCCCCCCCCCCCC	29.49	31492838
707	O-linked_Glycosylation	PSFPKTATTTPGFVD CCCCCCCCCCCCCCC	36.11	31492838
708	O-linked_Glycosylation	SFPKTATTTPGFVDT CCCCCCCCCCCCCCC	28.64	31492838
708	Phosphorylation	SFPKTATTTPGFVDT CCCCCCCCCCCCCCC	28.64	-
709	Phosphorylation	FPKTATTTPGFVDTR CCCCCCCCCCCCCCC	19.63	-
737	Phosphorylation	GSISAPPSVCSDPDC CCCCCCCCCCCCCCC	34.40	25850435
740	Phosphorylation	SAPPSVCSDPDCEGH CCCCCCCCCCCCCCC	50.45	25850435
787	Acetylation	STNQKEGKYCDCCYC CCCCCCCCCCCCCCC	43.74	25953088
837	Phosphorylation	PKKMDQISERESVVD CCHHHHHHHHHHHCC	25.60	28555341
841	Phosphorylation	DQISERESVVDHRRV HHHHHHHHHCCHHHH	33.39	28555341
857	Phosphorylation	DLLQFINSSETKPVS HHHHHHHCCCCCCCC	25.41	21712546
858	Phosphorylation	LLQFINSSETKPVSS HHHHHHCCCCCCCCH	44.81	25627689
861	Ubiquitination	FINSSETKPVSSTRA HHHCCCCCCCCHHHH	39.09	29967540
864	Phosphorylation	SSETKPVSSTRAAKR CCCCCCCCHHHHHHH	34.22	21712546
876	Phosphorylation	AKRARHKQRKLEEKA HHHHHHHHHHHHHHH	41.43	32142685
883	Ubiquitination	QRKLEEKARLEAEAR HHHHHHHHHHHHHHH	25.27	29967540
918	2-Hydroxyisobutyrylation	EEEEDRFKEEFQRLQ HHHHHHHHHHHHHHH	58.17	-
933	Phosphorylation	ELQKLRAVKKKKKER HHHHHHHHHHHHCCC	8.26	32142685
959	Phosphorylation	TRNFQAATESVPNSG HHHHHHHHHCCCCCC	31.63	28450419
961	Phosphorylation	NFQAATESVPNSGNI HHHHHHHCCCCCCCC	38.22	28450419
965	Phosphorylation	ATESVPNSGNIHNGS HHHCCCCCCCCCCCC	27.44	23927012
972	Phosphorylation	SGNIHNGSLEQTEEP CCCCCCCCCCCCCCC	33.77	23927012
976	Phosphorylation	HNGSLEQTEEPETSS CCCCCCCCCCCCCCC	32.70	23927012
981	Phosphorylation	EQTEEPETSSHSPSR CCCCCCCCCCCCCCC	46.36	23401153
982	Phosphorylation	QTEEPETSSHSPSRH CCCCCCCCCCCCCCC	25.13	23927012
983	Phosphorylation	TEEPETSSHSPSRHM CCCCCCCCCCCCCCC	35.09	23927012
983 (in isoform 2)	Phosphorylation	-	35.09	24719451
985	Phosphorylation	EPETSSHSPSRHMNH CCCCCCCCCCCCCCC	26.90	23927012
985 (in isoform 2)	Phosphorylation	-	26.90	-
987	Phosphorylation	ETSSHSPSRHMNHSE CCCCCCCCCCCCCCC	37.52	23401153
993	Phosphorylation	PSRHMNHSEPRPGLG CCCCCCCCCCCCCCC	44.27	28555341
1011	Phosphorylation	DAADPVDTRDSKFLL CCCCCCCCCCCCCCC	36.29	26552605
1082	Phosphorylation	KPRAQTESKAKVVDL CCCCCCHHHHHHHHH	41.10	29759185
1091	Phosphorylation	AKVVDLMSITEQKRE HHHHHHHHHHHHHHH	33.39	29759185
1093	Phosphorylation	VVDLMSITEQKREER HHHHHHHHHHHHHHH	25.67	29759185
1101	Ubiquitination	EQKREERKVNSNNNN HHHHHHHHCCCCCCC	49.39	30230243
1120	Phosphorylation	NHIKDEKSNPTPMEP HHHCCCCCCCCCCCC	46.09	23403867
1123	Phosphorylation	KDEKSNPTPMEPTSP CCCCCCCCCCCCCCC	39.25	23403867
1123	Ubiquitination	KDEKSNPTPMEPTSP CCCCCCCCCCCCCCC	39.25	30230243
1128	Phosphorylation	NPTPMEPTSPGEHQQ CCCCCCCCCCCCCCC	33.96	23401153
1129	Phosphorylation	PTPMEPTSPGEHQQN CCCCCCCCCCCCCCC	41.44	23927012
1137	Phosphorylation	PGEHQQNSKLVLAES CCCCCCCCEEEEECC	24.03	23927012
1144	Phosphorylation	SKLVLAESPQPKGKN CEEEEECCCCCCCCC	24.19	19664994
1144 (in isoform 2)	Phosphorylation	-	24.19	24719451
1151	Phosphorylation	SPQPKGKNKKNKKKK CCCCCCCCCCCCCCC	70.02	32142685
1165 (in isoform 2)	Phosphorylation	-	19.49	21815630
1165 (in isoform 6)	Phosphorylation	-	19.49	21815630
1166	Phosphorylation	GDRVNNSIDGVSLLL CCCCCCCCCHHHHCC	6.09	32142685
1187 (in isoform 5)	Phosphorylation	-	20.52	21815630
1208 (in isoform 2)	Phosphorylation	-	48.43	24719451
1220	Phosphorylation	PKDIDLDSVDMDETE CCCCCCCCCCCCCHH	27.58	20873877
1249	Phosphorylation	RQTRQRLSINWSNFS HHHHHHHCCCCCCCC	18.96	28450419
1253	Phosphorylation	QRLSINWSNFSLKKA HHHCCCCCCCCCCHH	24.41	28102081
1256	Phosphorylation	SINWSNFSLKKATFA CCCCCCCCCCHHHHC	43.46	23186163
1258	Methylation	NWSNFSLKKATFAAH CCCCCCCCHHHHCCC	38.88	-
1335	Ubiquitination	----------------------------------------------------------------------------- -----------------------------------------------------------------------------		30230243
1363	Phosphorylation	--------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------		32142685
1378	Phosphorylation	------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------		32142685
1392	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------		30230243
1420	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------		32142685
1435	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F193A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of F193A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F193A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of F193A_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F193A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-1144, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642 AND SER-1144, ANDMASS SPECTROMETRY.	18669648 [Abstract]