F186A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F186A_HUMAN
• UniProt AC: A6NE01
• Protein Name: Protein FAM186A
• Gene Name: FAM186A
• Organism: Homo sapiens (Human).
• Sequence Length: 2351
• Protein Sequence: MFFKMKNEIDNDPESEKCIKDSTIMRREPQNILSPLMLPNLEIPFSVKDIISRIERAQLHRAREDIDMQLSEIMNNVHRIMTRYTLVFNSSSERNVSLTEHKKKQRTNFLEKMATYAKTIEIREKTLANILAWLEEWNDVLSEMTLMDVDEHHHWIAQMELLPDTLKAIENNVKILSRFSTSFLDEKKKQKKKILSRGTLWKSWKERVIKRPSTARALRPDQMISDQLATNTKVSEIQGMLQELIGTTMFSTLENNAIKYISSTIVNLSTALSMLNDELKCVNFQSSTVYAHETSEAEKELSLKIIRDLSNENEMLQQKLQDAEEKCEQLIRSKIVIEQLYAKLSTSSTLKVLPGPSPQSSRAIIKVGDTEDNMDNILDKELENIVDEVQRKETKDSGIKWDSTISYTAQAERTPDLTELRQQPVASEDISEDSTKDNVSLKKGDFYQEDETDEYQSWKRSHKKATYVYETSGPNLSDNKSGQKVSEAKPSQYYELQVLKKKRKEMKSFSEDKSKSPTEAKRKHLSLTETKSQGGKSGTSMMMLEQFRKVKRESPFDKRPTAAEIKVEPTTESLDKEGKGEIRSLVEPLSMIQFDDTAEPQKGKIKGKKHHISSGTITSKEEKTEEKEELTKQVKSHQLVKSLSRVAKETSESTRVLESPDGKSEQSNLEEFQEAIMAFLKQKIDNIGKAFDKKTVPKEEELLKRAEAEKLGIIKAKMEEYFQKVAETVTKILRKYKDTKKEEQVGEKPIKQKKVVSFMPGLHFQKSPISAKSESSTLLSYESTDPVINNLIQMILAEIESERDIPTVSTVQKDHKEKEKQRQEQYLQEGQEQMSGMSLKQQLLGERNLLKEHYEKISENWEEKKAWLQMKEGKQEQQSQKQWQEEEMWKEEQKQATPKQAEQEEKQKQRGQEEEELPKSSLQRLEEGTQKMKTQGLLLEKENGQMRQIQKEAKHLGPHRRREKGKEKQKPERGLEDLERQIKTKDQMQMKETQPKELEKMVIQTPMTLSPRWKSVLKDVQRSYEGKEFQRNLKTLENLPDEKEPISITPPPSLQYSLPGALPISGQPLTKCIHLTPQQAQEVGITLTPQQAQAQGITLTLQQAQELGIPLTPQQAQALEILFTPQQAQALGIPLTPQQTQVQGITLTPQQDQAPGISLTTQQAQKLGIPLTPQQAQALGIPLTPQQAQELGIPLTPQQAQALRVSLTPQQAQELGIPLTPQQAQALGITLTLQQAQQLGIPLTPQQAQALGITLTPKQVQELGIPLTPQQAQALGITLTPKQAQELGIPLNPQQAQTLGIPLTPKQAQALGIPFTPQQAQALGIPLTPQQAQTQEITLTPQQAQALGMPLTTQQAQELGIPLTPQHAQALGMPLTTQQAQELGIPLTPQQAQALGMPLTTQQAQELGIPLTPQQAQELGIPFTPQQAQAQEITLTPQQAQALGMPLTAQQAQELGITLTPQQAQELGIPLTPQQAQALGIPLIPPQAQELGIPLTPQQAQALGILLIPPQAQELGIPLTPQQAQALGIPLIPPQAQELGIPLTPQQVQALGIPLIPPQAQELEIPLTPQQAQALGIPLTPQQAQELGIPLTPQQAQELGIPLTPQQAQAQGIPLTPQQAQALGISLTPQQAQAQGITLTPQQAQALGVPITPVNAWVSAVTLTSEQTHALESPMNLEQAQEQLLKLGVPLTLDKAHTLGSPLTLKQVQWSHRPFQKSKASLPTGQSIISRLSPSLRLSLASSAPTAEKSSIFGVSSTPLQISRVPLNQGPFAPGKPLEMGILSEPGKLGAPQTLRSSGQTLVYGGQSTSAQFPAPQAPPSPGQLPISRAPPTPGQPFIAGVPPTSGQIPSLWAPLSPGQPLVPEASSIPGDLLESGPLTFSEQLQEFQPPATAEQSPYLQAPSTPGQHLATWTLPGRASSLWIPPTSRHPPTLWPSPAPGKPQKSWSPSVAKKRLAIISSLKSKSVLIHPSAPDFKVAQVPFTTKKFQMSEVSDTSEETQILRDTFAIESFRTFQSHFTKYRTPVYQTPYTDERALLTLMKPTTSPSSLTTLLRTSQISPLEWYQKSRFPPIDKPWILSSVSDTKKPKVMVPPSSPQELEEKRYFVDVEAQKKNLILLNQAIKTCGLPSQLHTMARTLIIEILHMDTVQLGYLFRKYIAYRLIQHARNNIMKRLKAIQNTGKGYEARNLHMMLSRLDDYGKKVMQVWTEKQKSLGQKRNQCLKKMIHVFNQLKKIHELNLSQPIPLIIEEKQIPASTTFVQKPFLKLLMEEDRTSDICKKFRQQEDQTEAIWNVDLSTSSYPIAEKTSMHSLWAQLGGYPDIPRLLQLEVQSTFRKSLASLQSRVKKIPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	REPQNILSPLMLPNL CCCCCCCCCCCCCCC	16.52	22210691
52	Phosphorylation	FSVKDIISRIERAQL CCHHHHHHHHHHHHH	27.78	22210691
79	Dimethylation	EIMNNVHRIMTRYTL HHHHHHHHHHHHEEE	18.98	-
79	Methylation	EIMNNVHRIMTRYTL HHHHHHHHHHHHEEE	18.98	-
83	Dimethylation	NVHRIMTRYTLVFNS HHHHHHHHEEEEECC	12.69	-
83	Methylation	NVHRIMTRYTLVFNS HHHHHHHHEEEEECC	12.69	-
177	Phosphorylation	ENNVKILSRFSTSFL HHHHHHHHHHCCCCC	34.45	29052541
180	Phosphorylation	VKILSRFSTSFLDEK HHHHHHHCCCCCCHH	23.25	29052541
181	Phosphorylation	KILSRFSTSFLDEKK HHHHHHCCCCCCHHH	22.30	29052541
182	Phosphorylation	ILSRFSTSFLDEKKK HHHHHCCCCCCHHHH	23.71	29052541
214	Phosphorylation	RVIKRPSTARALRPD HHHCCCCHHHHHCHH	23.89	24247654
260	Phosphorylation	LENNAIKYISSTIVN HHHHHHHHHHHHHHC	10.42	22210691
262	Phosphorylation	NNAIKYISSTIVNLS HHHHHHHHHHHHCHH	20.52	22210691
263	Phosphorylation	NAIKYISSTIVNLST HHHHHHHHHHHCHHH	16.76	-
269	Phosphorylation	SSTIVNLSTALSMLN HHHHHCHHHHHHHHC	13.36	22210691
270	Phosphorylation	STIVNLSTALSMLND HHHHCHHHHHHHHCC	34.48	22210691
273	Phosphorylation	VNLSTALSMLNDELK HCHHHHHHHHCCCCE	20.82	-
280	Ubiquitination	SMLNDELKCVNFQSS HHHCCCCEEEECCCC	33.80	-
455	Phosphorylation	QEDETDEYQSWKRSH CCCCCHHHHHHHHHH	15.62	29116813
549	Acetylation	MMLEQFRKVKRESPF HHHHHHHHHCCCCCC	54.09	7704639
551	Acetylation	LEQFRKVKRESPFDK HHHHHHHCCCCCCCC	54.18	7704647
613	Phosphorylation	KGKKHHISSGTITSK CCEECCCCCCCCCCH	20.54	26074081
614	Phosphorylation	GKKHHISSGTITSKE CEECCCCCCCCCCHH	39.08	26074081
616	Phosphorylation	KHHISSGTITSKEEK ECCCCCCCCCCHHHH	24.03	26074081
618	Phosphorylation	HISSGTITSKEEKTE CCCCCCCCCHHHHHH	33.32	26074081
619	Phosphorylation	ISSGTITSKEEKTEE CCCCCCCCHHHHHHH	33.93	26074081
632	Acetylation	EEKEELTKQVKSHQL HHHHHHHHHHHHHHH	66.76	91245
648	Acetylation	KSLSRVAKETSESTR HHHHHHHHHHCCCCE	59.68	91247
664	Phosphorylation	LESPDGKSEQSNLEE EECCCCCCCCCCHHH	46.53	24719451
715	Ubiquitination	AEKLGIIKAKMEEYF HHHHCCHHHHHHHHH	39.78	-
767	Phosphorylation	PGLHFQKSPISAKSE CCCCCCCCCCCCCCC	19.38	-
770	Phosphorylation	HFQKSPISAKSESST CCCCCCCCCCCCCCC	32.78	-
773	Phosphorylation	KSPISAKSESSTLLS CCCCCCCCCCCCCCC	42.29	-
826	Phosphorylation	EKQRQEQYLQEGQEQ HHHHHHHHHHHHHHH	15.03	28842319
854	Phosphorylation	RNLLKEHYEKISENW HHHHHHHHHHHHHCH	21.73	-
874	Acetylation	WLQMKEGKQEQQSQK HHHHHHHHHHHHHHH	52.32	19807601
1005	Phosphorylation	LEKMVIQTPMTLSPR HHHHHHCCCCCCCHH	12.14	23663014
1008	Phosphorylation	MVIQTPMTLSPRWKS HHHCCCCCCCHHHHH	25.86	23663014
1010	Phosphorylation	IQTPMTLSPRWKSVL HCCCCCCCHHHHHHH	11.85	22210691
1024	Phosphorylation	LKDVQRSYEGKEFQR HHHHHHHHCCHHHHH	30.78	-
1698	Phosphorylation	LTLDKAHTLGSPLTL CCCCCCHHCCCCCEE	37.36	16674116
1701	Phosphorylation	DKAHTLGSPLTLKQV CCCHHCCCCCEEEEE	21.61	-
1704	Phosphorylation	HTLGSPLTLKQVQWS HHCCCCCEEEEEECC	34.98	16674116
1727	Phosphorylation	ASLPTGQSIISRLSP CCCCCCHHHHHHHCH	24.20	24719451
1730	Phosphorylation	PTGQSIISRLSPSLR CCCHHHHHHHCHHHH	26.04	24719451
1794	Phosphorylation	GKLGAPQTLRSSGQT CCCCCCEEHHHCCCE	24.07	30278072
1797	Phosphorylation	GAPQTLRSSGQTLVY CCCEEHHHCCCEEEE	41.77	24043423
1798	Phosphorylation	APQTLRSSGQTLVYG CCEEHHHCCCEEEEC	28.61	24043423
1801	Phosphorylation	TLRSSGQTLVYGGQS EHHHCCCEEEECCCC	23.01	24043423
1804	Phosphorylation	SSGQTLVYGGQSTSA HCCCEEEECCCCCCC	20.74	24043423
1808	Phosphorylation	TLVYGGQSTSAQFPA EEEECCCCCCCCCCC	27.83	24043423
1809	Phosphorylation	LVYGGQSTSAQFPAP EEECCCCCCCCCCCC	21.86	24043423
1810	Phosphorylation	VYGGQSTSAQFPAPQ EECCCCCCCCCCCCC	25.89	24043423
1821	Phosphorylation	PAPQAPPSPGQLPIS CCCCCCCCCCCCCCC	40.37	24043423
1960	Phosphorylation	KKRLAIISSLKSKSV HHHHHHHHHHCCCCE	24.41	24719451
1961	Phosphorylation	KRLAIISSLKSKSVL HHHHHHHHHCCCCEE	29.43	-
1964	Phosphorylation	AIISSLKSKSVLIHP HHHHHHCCCCEEECC	35.14	-
1965	Acetylation	IISSLKSKSVLIHPS HHHHHCCCCEEECCC	42.89	19817505
1972	Phosphorylation	KSVLIHPSAPDFKVA CCEEECCCCCCCEEE	37.97	-
1977	Acetylation	HPSAPDFKVAQVPFT CCCCCCCEEEECCCC	44.00	19817511
1991	Phosphorylation	TTKKFQMSEVSDTSE CCCEEECCCCCCCCH	24.86	30206219
1994	Phosphorylation	KFQMSEVSDTSEETQ EEECCCCCCCCHHHH	30.99	30206219
1996	Phosphorylation	QMSEVSDTSEETQIL ECCCCCCCCHHHHHH	30.45	30206219
1997	Phosphorylation	MSEVSDTSEETQILR CCCCCCCCHHHHHHH	38.12	30206219
2000	Phosphorylation	VSDTSEETQILRDTF CCCCCHHHHHHHHHH	19.50	30206219
2039	Phosphorylation	TDERALLTLMKPTTS CCHHHHHHHHCCCCC	26.17	-
2052	Phosphorylation	TSPSSLTTLLRTSQI CCHHHHHHHHHHCCC	29.14	-
2095	Phosphorylation	PKVMVPPSSPQELEE CCCCCCCCCHHHHHH	48.89	29514088
2096	Phosphorylation	KVMVPPSSPQELEEK CCCCCCCCHHHHHHH	36.05	29514088
2185	Phosphorylation	IQNTGKGYEARNLHM HHHCCCCHHHHHHHH	15.20	24719451
2195	Phosphorylation	RNLHMMLSRLDDYGK HHHHHHHHHHHHHHH	16.95	24719451
2200	Phosphorylation	MLSRLDDYGKKVMQV HHHHHHHHHHHHHHH	30.43	30243723
2225	Acetylation	KRNQCLKKMIHVFNQ HHHHHHHHHHHHHHH	30.09	18586115
2234	Acetylation	IHVFNQLKKIHELNL HHHHHHHHHHHHCCC	39.66	18586121
2333	Phosphorylation	LLQLEVQSTFRKSLA HHHHHHHHHHHHHHH	34.39	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F186A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F186A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F186A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of F186A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.