F185A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F185A_HUMAN
• UniProt AC: Q8N0U4
• Protein Name: Protein FAM185A
• Gene Name: FAM185A
• Organism: Homo sapiens (Human).
• Sequence Length: 392
• Protein Sequence: MLAPCSGWELGCFRLCLRQVRLWAGAGRWACWACQARPYSSGGSERWPGSETEVPPPGPGRRTLKEWTLQVSPFGRLRARLPCHLAVRPLDPLTYPDGDRVLVAVCGVEGGVRGLDGLQVKYDEDLEEMAIVSDTIHPQASVEVNAPLKFGLDIKSSGSGCVKVQSIEGDNCKIETEHGTSILQSVKGQKLHVQTKGGKVICLGTVYGNIDIHASDKSAVTIDKLQGSSVTVSTEDGLLKAKYLYTESSFLSSAAGDITLGSVHGNITLQSKMGNITVDSSSGCLKASTNQGAIDVYVSQLGKVELKSHKGSIIVKVPSSLQAHLQLSGKEVDVNSEVHVQEMAEVRKDDVVTVTGLMNQASKREKWIKADAPKGTVSFRRQSWFQSLKLQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	GSERWPGSETEVPPP CCCCCCCCCCCCCCC	36.95	28270605
52	Phosphorylation	ERWPGSETEVPPPGP CCCCCCCCCCCCCCC	43.94	28270605
68	Phosphorylation	RRTLKEWTLQVSPFG CCCCCEEEEEECCCC	14.38	29083192
72	Phosphorylation	KEWTLQVSPFGRLRA CEEEEEECCCCHHHC	11.10	29083192
121	Acetylation	GLDGLQVKYDEDLEE CCCCCEEEECCCHHH	33.74	25038526
176	Phosphorylation	GDNCKIETEHGTSIL CCCEEEEECCCCCHH	36.43	-
185	Phosphorylation	HGTSILQSVKGQKLH CCCCHHHHHCCCEEE	23.50	-
224	Acetylation	KSAVTIDKLQGSSVT CCCEEEEECCCCEEE	38.57	25038526
303	Acetylation	VYVSQLGKVELKSHK EEEECCCCEEEECCC	40.92	25038526
307	Acetylation	QLGKVELKSHKGSII CCCCEEEECCCCEEE	36.69	25038526
312	Phosphorylation	ELKSHKGSIIVKVPS EEECCCCEEEEECCC	17.59	22468782
319	Phosphorylation	SIIVKVPSSLQAHLQ EEEEECCCHHHHHEE	46.82	22468782
353	Phosphorylation	VRKDDVVTVTGLMNQ HCCCCEEEEEECCCC	16.52	24043423
355	Phosphorylation	KDDVVTVTGLMNQAS CCCEEEEEECCCCHH	18.42	25072903
362	Phosphorylation	TGLMNQASKREKWIK EECCCCHHHHHHEEE	23.60	25072903
383	Phosphorylation	TVSFRRQSWFQSLKL CEEEECHHHHHHCCC	28.22	24275569
387	Phosphorylation	RRQSWFQSLKLQD-- ECHHHHHHCCCCC--	20.28	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F185A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F185A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F185A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of F185A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.