F16P1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F16P1_MOUSE
• UniProt AC: Q9QXD6
• Protein Name: Fructose-1,6-bisphosphatase 1
• Gene Name: Fbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 338
• Protein Description: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain..
• Protein Sequence: MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANHAPFET ------CCCCCCCCC	19.26	-
9	Phosphorylation	ANHAPFETDISTLTR CCCCCCCCCHHHHHH	38.73	23984901
12	Phosphorylation	APFETDISTLTRFVM CCCCCCHHHHHHHHH	21.85	23984901
13	Phosphorylation	PFETDISTLTRFVME CCCCCHHHHHHHHHH	32.27	23984901
15	Phosphorylation	ETDISTLTRFVMEQG CCCHHHHHHHHHHCC	23.34	23984901
24	Acetylation	FVMEQGRKAQGTGEL HHHHCCCCCCCHHHH	52.46	22733758
24	Malonylation	FVMEQGRKAQGTGEL HHHHCCCCCCCHHHH	52.46	26320211
24	Ubiquitination	FVMEQGRKAQGTGEL HHHHCCCCCCCHHHH	52.46	-
28	Phosphorylation	QGRKAQGTGELTQLL CCCCCCCHHHHHHHH	18.53	23984901
32	Phosphorylation	AQGTGELTQLLNSLC CCCHHHHHHHHHHHH	16.93	23984901
39	S-palmitoylation	TQLLNSLCTAIKAIS HHHHHHHHHHHHHHH	2.13	28526873
39	S-nitrosylation	TQLLNSLCTAIKAIS HHHHHHHHHHHHHHH	2.13	22178444
63	Phosphorylation	QLYGIAGSTNVTGDQ HHHCCCCCCCCCCHH	14.05	23984901
64	Phosphorylation	LYGIAGSTNVTGDQV HHCCCCCCCCCCHHH	32.56	23984901
67	Ubiquitination	IAGSTNVTGDQVKKL CCCCCCCCCHHHHHH	36.79	27667366
67	Phosphorylation	IAGSTNVTGDQVKKL CCCCCCCCCHHHHHH	36.79	23984901
72	Malonylation	NVTGDQVKKLDILSN CCCCHHHHHHHHCCC	41.82	26073543
72	Acetylation	NVTGDQVKKLDILSN CCCCHHHHHHHHCCC	41.82	23954790
72	Ubiquitination	NVTGDQVKKLDILSN CCCCHHHHHHHHCCC	41.82	-
73	Ubiquitination	VTGDQVKKLDILSND CCCHHHHHHHHCCCH	53.16	22790023
73	Acetylation	VTGDQVKKLDILSND CCCHHHHHHHHCCCH	53.16	15618629
135	Phosphorylation	DCLVSIGTIFGIYRK EEEEEEHHHHEEEEC	16.09	-
140	Phosphorylation	IGTIFGIYRKKSTDE EHHHHEEEECCCCCC	19.43	-
143	Acetylation	IFGIYRKKSTDEPSE HHEEEECCCCCCCCH	49.98	23201123
144	Phosphorylation	FGIYRKKSTDEPSEK HEEEECCCCCCCCHH	44.09	25521595
145	Phosphorylation	GIYRKKSTDEPSEKD EEEECCCCCCCCHHH	53.94	21743459
149	Phosphorylation	KKSTDEPSEKDALQP CCCCCCCCHHHCCCC	56.05	22324799
151	Succinylation	STDEPSEKDALQPGR CCCCCCHHHCCCCCH	53.27	23806337
151	Acetylation	STDEPSEKDALQPGR CCCCCCHHHCCCCCH	53.27	23806337
151	Malonylation	STDEPSEKDALQPGR CCCCCCHHHCCCCCH	53.27	26320211
151	Succinylation	STDEPSEKDALQPGR CCCCCCHHHCCCCCH	53.27	-
151	Ubiquitination	STDEPSEKDALQPGR CCCCCCHHHCCCCCH	53.27	27667366
206	Malonylation	RDVKMKKKGNIYSLN CCCCCCCCCCEEECC	52.23	26320211
206	Ubiquitination	RDVKMKKKGNIYSLN CCCCCCCCCCEEECC	52.23	-
210	Phosphorylation	MKKKGNIYSLNEGYA CCCCCCEEECCCHHH	15.88	23984901
211	Phosphorylation	KKKGNIYSLNEGYAK CCCCCEEECCCHHHC	22.41	23984901
216	Phosphorylation	IYSLNEGYAKDFDPA EEECCCHHHCCCCHH	12.33	25521595
218	Acetylation	SLNEGYAKDFDPAIN ECCCHHHCCCCHHHH	50.90	22733758
218	Ubiquitination	SLNEGYAKDFDPAIN ECCCHHHCCCCHHHH	50.90	-
218	Succinylation	SLNEGYAKDFDPAIN ECCCHHHCCCCHHHH	50.90	23954790
241	Phosphorylation	PPDGSAPYGARYVGS CCCCCCCCCCHHHHH	24.12	25195567
245	Phosphorylation	SAPYGARYVGSMVAD CCCCCCHHHHHHHHH	14.50	25521595
259	Phosphorylation	DIHRTLVYGGIFLYP HHHHHHEECEEEEEE	16.85	26032504
265	Phosphorylation	VYGGIFLYPANKKSP EECEEEEEECCCCCC	6.91	26032504
269	Malonylation	IFLYPANKKSPSGKL EEEEECCCCCCCCCE	57.65	26073543
269	Acetylation	IFLYPANKKSPSGKL EEEEECCCCCCCCCE	57.65	23954790
269	Ubiquitination	IFLYPANKKSPSGKL EEEEECCCCCCCCCE	57.65	-
270	Malonylation	FLYPANKKSPSGKLR EEEECCCCCCCCCEE	68.36	26073543
271	Phosphorylation	LYPANKKSPSGKLRL EEECCCCCCCCCEEE	26.38	21183079
275	Malonylation	NKKSPSGKLRLLYEC CCCCCCCCEEEEEEE	34.47	26320211
282	S-palmitoylation	KLRLLYECNPIAYVM CEEEEEEECCHHHHH	4.66	28526873
301	Malonylation	GLATTGDKDILDIVP CCCCCCCCCHHHCCC	48.27	25418362
301	Succinylation	GLATTGDKDILDIVP CCCCCCCCCHHHCCC	48.27	23954790
301	Acetylation	GLATTGDKDILDIVP CCCCCCCCCHHHCCC	48.27	22733758
314	Sumoylation	VPTEIHQKAPVVMGS CCCCHHHCCCEEECC	40.26	28289178
321	Phosphorylation	KAPVVMGSSEDVQEF CCCEEECCCHHHHHH	16.68	23984901
322	Phosphorylation	APVVMGSSEDVQEFL CCEEECCCHHHHHHH	31.89	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F16P1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F16P1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F16P1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of F16P1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.