dbPTM

F107B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F107B_HUMAN
UniProt AC	Q9H098
Protein Name	Protein FAM107B
Gene Name	FAM107B
Organism	Homo sapiens (Human).
Sequence Length	131
Subcellular Localization
Protein Description
Protein Sequence	MAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEKRKRDQVIKQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKLQEEQENAPEFVKVKGNLRRTGQEVAQAQES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEPDYIED ------CCCCCCCCC	36.71	19413330
6	Phosphorylation	--MAEPDYIEDDNPE --CCCCCCCCCCCHH	19.54	25394399
25	Acetylation	QKLINPVKTSRNHQD HHHCCCCCCCCCCHH	41.88	25953088
25	Ubiquitination	QKLINPVKTSRNHQD HHHCCCCCCCCCCHH	41.88	29967540
26	Phosphorylation	KLINPVKTSRNHQDL HHCCCCCCCCCCHHH	32.90	29083192
27	Phosphorylation	LINPVKTSRNHQDLH HCCCCCCCCCCHHHH	25.93	29083192
42	Acetylation	RELLMNQKRGLAPQN HHHHHHHHCCCCCCC	43.35	25953088
42	Ubiquitination	RELLMNQKRGLAPQN HHHHHHHHCCCCCCC	43.35	29967540
43	Methylation	ELLMNQKRGLAPQNK HHHHHHHCCCCCCCC	35.28	-
50	Acetylation	RGLAPQNKPELQKVM CCCCCCCCHHHHHHH	34.32	23749302
50	Ubiquitination	RGLAPQNKPELQKVM CCCCCCCCHHHHHHH	34.32	33845483
55	Ubiquitination	QNKPELQKVMEKRKR CCCHHHHHHHHHHHH	57.06	24816145
64	Ubiquitination	MEKRKRDQVIKQKEE HHHHHHHHHHHHHHH	42.75	29967540
68 (in isoform 2)	Phosphorylation	-	47.47	-
77	Ubiquitination	EEEAQKKKSDLEIEL HHHHHHHHHHHHHHH	57.12	33845483
78	Phosphorylation	EEAQKKKSDLEIELL HHHHHHHHHHHHHHH	57.20	28450419
81	Ubiquitination	QKKKSDLEIELLKRQ HHHHHHHHHHHHHHH	39.13	29967540
86	Ubiquitination	DLEIELLKRQQKLEQ HHHHHHHHHHHHHHH	61.87	33845483
89	Ubiquitination	IELLKRQQKLEQLEL HHHHHHHHHHHHHHH	57.23	33845483
90	Ubiquitination	ELLKRQQKLEQLELE HHHHHHHHHHHHHHH	45.73	30230243
94	Ubiquitination	RQQKLEQLELEKQKL HHHHHHHHHHHHHHH	6.23	24816145
100	Acetylation	QLELEKQKLQEEQEN HHHHHHHHHHHHHHH	64.30	20167786
100	Ubiquitination	QLELEKQKLQEEQEN HHHHHHHHHHHHHHH	64.30	33845483
113	Ubiquitination	ENAPEFVKVKGNLRR HHCCCHHHCCCHHHH	43.48	33845483
113	Acetylation	ENAPEFVKVKGNLRR HHCCCHHHCCCHHHH	43.48	26051181
116	Ubiquitination	PEFVKVKGNLRRTGQ CCHHHCCCHHHHHHH	41.20	33845483
121	Phosphorylation	VKGNLRRTGQEVAQA CCCHHHHHHHHHHHH	36.46	28674419
125	Ubiquitination	LRRTGQEVAQAQES- HHHHHHHHHHHHCC-	3.53	33845483
129	Ubiquitination	GQEVAQAQES----- HHHHHHHHCC-----	39.11	30230243
131	Phosphorylation	EVAQAQES------- HHHHHHCC-------	33.18	28450419
139	Ubiquitination	--------------- ---------------		33845483
152	Ubiquitination	---------------------------- ----------------------------		33845483
200	Ubiquitination	---------------------------------------------------------------------------- ----------------------------------------------------------------------------		29967540
217	Ubiquitination	--------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------		29967540
225	Ubiquitination	----------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------		33845483
230	Ubiquitination	---------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------		24816145
252	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------		33845483
261	Ubiquitination	----------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------		33845483
265	Ubiquitination	--------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------		30230243
275	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------		33845483
288	Ubiquitination	-------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------		33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F107B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of F107B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F107B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of F107B_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F107B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]