EZRI_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EZRI_RAT
• UniProt AC: P31977
• Protein Name: Ezrin
• Gene Name: Ezr
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 586
• Subcellular Localization: Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection . Cell projection, microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic
• Protein Description: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity)..
• Protein Sequence: MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVADELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKSGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMLREKEELMLRLQDFEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEADRMAALRAKEELERQAQDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPMGYSAELSSEGILDDRNEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MPKPINVRVT -----CCCCEEEEEE	58.17	22902405
35	Acetylation	QLFDQVVKTIGLREV HHHHHHHHHHCCCHH	35.25	22636143
57	Phosphorylation	VDNKGFPTWLKLDKK ECCCCCCCEEECCCC	40.96	22673903
60	Acetylation	KGFPTWLKLDKKVSA CCCCCEEECCCCCCH	46.32	22902405
79	Acetylation	KENPVQFKFRAKFYP HHCCCCEEEEECCCC	19.49	22902405
139	Acetylation	AKFGDYNKEMHKSGY HHHCCCCHHHHHCCC	50.62	22902405
143	Acetylation	DYNKEMHKSGYLSSE CCCHHHHHCCCCCCC	44.24	22902405
144	Phosphorylation	YNKEMHKSGYLSSER CCHHHHHCCCCCCCC	20.28	22673903
146	Phosphorylation	KEMHKSGYLSSERLI HHHHHCCCCCCCCCC	15.53	22673903
148	Phosphorylation	MHKSGYLSSERLIPQ HHHCCCCCCCCCCCH	22.97	22673903
149	Phosphorylation	HKSGYLSSERLIPQR HHCCCCCCCCCCCHH	24.92	22673903
162	Acetylation	QRVMDQHKLSRDQWE HHHHHHHCCCHHHHH	42.39	22902405
184	Acetylation	AEHRGMLKDSAMLEY HHHCCCCCCHHHHHH	40.52	22902405
237	Acetylation	KDDKLTPKIGFPWSE CCCCCCCCCCCCHHH	50.67	24213405
243	Phosphorylation	PKIGFPWSEIRNISF CCCCCCHHHHCCCCC	24.31	22673903
249	Phosphorylation	WSEIRNISFNDKKFV HHHHCCCCCCCCEEE	22.88	22673903
253	Acetylation	RNISFNDKKFVIKPI CCCCCCCCEEEEEEC	49.57	4276375
254	Acetylation	NISFNDKKFVIKPID CCCCCCCEEEEEECC	47.96	4276377
258	Acetylation	NDKKFVIKPIDKKAP CCCEEEEEECCCCCC	30.53	22636127
270	Phosphorylation	KAPDFVFYAPRLRIN CCCCCEEEECCHHCC	15.47	-
332	Phosphorylation	TEKKRRETVEREKEQ HHHHHHHHHHHHHHH	26.34	22673903
337	Acetylation	RETVEREKEQMLREK HHHHHHHHHHHHHHH	60.51	22902405
344	Acetylation	KEQMLREKEELMLRL HHHHHHHHHHHHHHH	50.48	22902405
363	Ubiquitination	QKTKRAEKELSEQIE HHHHHHHHHHHHHHH	64.07	-
366	Phosphorylation	KRAEKELSEQIEKAL HHHHHHHHHHHHHHH	28.66	-
400	Acetylation	RMAALRAKEELERQA HHHHHHHHHHHHHHH	45.33	-
424	Phosphorylation	LAAELAEYTAKIALL HHHHHHHHHHHHHHH	13.34	21940666
438	Acetylation	LEEARRRKEDEVEEW HHHHHHCCHHHHHHH	68.64	22902405
458	Ubiquitination	EAQDDLVKTKEELHL HHHHHHHCCHHHHEE	62.26	-
478	Phosphorylation	PPPPPPVYEPVNYHV CCCCCCCCCCCCHHH	21.93	-
523	Acetylation	KRITEAEKNERVQRQ HCCCHHHHHHHHHHH	71.77	22902405
533	Phosphorylation	RVQRQLLTLSNELSQ HHHHHHHHHHHHHHH	36.41	28432305
535	Phosphorylation	QRQLLTLSNELSQAR HHHHHHHHHHHHHHH	24.03	22108457
539	Phosphorylation	LTLSNELSQARDENK HHHHHHHHHHHHHCC	18.67	28432305
567	Phosphorylation	QGRDKYKTLRQIRQG CCHHHHHHHHHHHCC	24.88	16938849

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
146	Y	Phosphorylation	Kinase	PDGFR	-	Uniprot
567	T	Phosphorylation	Kinase	PRKCI	F1M7Y5	Uniprot
567	T	Phosphorylation	Kinase	MAP3K14	Q99558	GPS
567	T	Phosphorylation	Kinase	ROCK2	Q62868	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EZRI_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EZRI_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of EZRI_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.