EYS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EYS_HUMAN
• UniProt AC: Q5T1H1
• Protein Name: Protein eyes shut homolog
• Gene Name: EYS
• Organism: Homo sapiens (Human).
• Sequence Length: 3165
• Subcellular Localization: Secreted . Localizes in the photoreceptor cell layer.
• Protein Description: Required to maintain the integrity of photoreceptor cells..
• Protein Sequence: MTDKSIVILSLMVFHSSFINGKTCRRQLVEEWHPQPSSYVVNWTLTENICLDFYRDCWFLGVNTKIDTSGNQAVPQICPLQIQLGDILVISSEPSLQFPEINLMNVSETSFVGCVQNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPCPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAKHSLLSSADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADIELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEYQAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATEITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQYGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTVSATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCVRYYGDSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALILIVILEKPKPAERKVKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIELIKLEGYNVYDGDEQNEVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	LSLMVFHSSFINGKT EHHHHHHHHHCCCHH	18.58	-
23	Phosphorylation	SSFINGKTCRRQLVE HHHCCCHHHHHHHHH	16.79	-
166	N-linked_Glycosylation	CPLGLRLNVTVKQQF CCCCEEEEEEEEHHH	22.45	UniProtKB CARBOHYD
269	N-linked_Glycosylation	PHVCFHGNCSNITSN CCEEEECCCCCCCCC	19.92	UniProtKB CARBOHYD
272	N-linked_Glycosylation	CFHGNCSNITSNSFI EEECCCCCCCCCCEE	43.70	UniProtKB CARBOHYD
311	N-linked_Glycosylation	WKRGICPNSSSAYTY EECCCCCCCCCCEEE	50.54	UniProtKB CARBOHYD
343	N-linked_Glycosylation	FSLVPCQNGTDCIKI EEEEECCCCCCEEEE	63.15	UniProtKB CARBOHYD
506	N-linked_Glycosylation	AYFFLAANCTEDATY EHHHHHCCCCCCCCC	27.86	UniProtKB CARBOHYD
566	N-linked_Glycosylation	AGNMYLENTTDDQEN HCCEEEECCCCCCCC	45.76	UniProtKB CARBOHYD
1109	Phosphorylation	TCICPRGYTGAYCEK EEECCCCCCCCCCCC	11.86	24719451
1247	Phosphorylation	IRRITCLTPIFQRTD HHHEEEECHHHCCCC	19.24	-
1338	Phosphorylation	RELSAKHSLLSSADV HHHHHHHCHHHCCCC	30.24	-
1442	Phosphorylation	DIELNRQSLLSRGFL CCEECHHHHHHHCHH	28.21	24719451
1445	Phosphorylation	LNRQSLLSRGFLLIA ECHHHHHHHCHHHHH	35.33	24719451
1476	Phosphorylation	IEEYSADSLISRREH HHHHCHHHHHHHHHH	27.58	24719451
1479	Phosphorylation	YSADSLISRREHWRL HCHHHHHHHHHHHHH	30.49	24719451
1558	Phosphorylation	ELSQTCATCSMTEIK HHHHHHHHCCCCHHH	13.78	-
1571	Phosphorylation	IKSSREFSDQVLHSK HHCCCCCCHHHHHCC	23.52	28509920
1577	Phosphorylation	FSDQVLHSKQSHFYE CCHHHHHCCCCHHHH	28.38	28509920
1673	Phosphorylation	LSIVPSQTISSDLMN HHHCCCCCCCHHHCC	27.45	-
1675	Phosphorylation	IVPSQTISSDLMNSD HCCCCCCCHHHCCCC	22.61	23532336
1676	Phosphorylation	VPSQTISSDLMNSDL CCCCCCCHHHCCCCC	30.80	-
1681	Phosphorylation	ISSDLMNSDLTSKMT CCHHHCCCCCCCCCC	21.74	-
1685	Phosphorylation	LMNSDLTSKMTTDEL HCCCCCCCCCCCCCC	27.94	-
1707	Phosphorylation	KLLKIRQYGITMGPT HHHHHHHHCCCCCHH	10.72	22210691
1721	Phosphorylation	TEVLNQESLLDMEKS HHHCCCHHHHCHHHC	25.19	22210691
1728	Phosphorylation	SLLDMEKSKGSHTLF HHHCHHHCCCCCEEE	29.01	28634298
1731	Phosphorylation	DMEKSKGSHTLFKLH CHHHCCCCCEEEEEC	19.62	28634298
1733	Phosphorylation	EKSKGSHTLFKLHPS HHCCCCCEEEEECCC	35.27	28634298
1740	Phosphorylation	TLFKLHPSDSSLDFE EEEEECCCCCCCCEE	39.10	28634298
1742	Phosphorylation	FKLHPSDSSLDFELN EEECCCCCCCCEEEE	36.82	28634298
1743	Phosphorylation	KLHPSDSSLDFELNL EECCCCCCCCEEEEE	36.63	28634298
1753	Phosphorylation	FELNLQIYPDVTLKT EEEEEEECCCCEEEE	4.76	28634298
1757	Phosphorylation	LQIYPDVTLKTYSEI EEECCCCEEEEHHHC	29.89	28634298
1819	Phosphorylation	VIRPDWPYFTDYMTS CCCCCCCHHHHHHHH	18.17	25884760
1823	Phosphorylation	DWPYFTDYMTSLKKE CCCHHHHHHHHHHHH	10.15	25884760
1833	Phosphorylation	SLKKEVKTSSEWSKW HHHHHHCCCCCHHCC	42.53	29083192
1834	Phosphorylation	LKKEVKTSSEWSKWE HHHHHCCCCCHHCCE	22.12	29083192
1835	Phosphorylation	KKEVKTSSEWSKWEL HHHHCCCCCHHCCEE	48.60	29083192
1845	Phosphorylation	SKWELQPSVQYQEFP HCCEECCCCCCCCCC	14.64	24043423
1848	Phosphorylation	ELQPSVQYQEFPTAS EECCCCCCCCCCCCC	14.09	24043423
1853	Phosphorylation	VQYQEFPTASRHLPF CCCCCCCCCCCCCCC	42.45	24043423
1855	Phosphorylation	YQEFPTASRHLPFTR CCCCCCCCCCCCCCC	23.78	24043423
1958	Phosphorylation	PGEAKFKSINTTVRV CCCCEECCCEEEEEE	24.97	29759185
1961	Phosphorylation	AKFKSINTTVRVDNG CEECCCEEEEEECCC	25.62	29759185
1962	Phosphorylation	KFKSINTTVRVDNGQ EECCCEEEEEECCCC	11.22	29759185
1971	Phosphorylation	RVDNGQKYTLLIRQE EECCCCEEEEEEEEE	8.50	-
2052	Phosphorylation	NWRSFIPSKAVKNYH CHHHHCCHHHHHEEE	28.56	24719451
2170	N-linked_Glycosylation	FVLEKEHNRTVTIYL EEEECCCCCEEEEEE	42.27	UniProtKB CARBOHYD
2419	Phosphorylation	NITQPRFSGTDAFGY ECCCCCCCCCCCCCC	41.90	30576142
2433	Phosphorylation	YTSFLAYSRISDISF CEEEEEEEECCCCEE	19.96	30576142
2442	Phosphorylation	ISDISFHYEFHLKFQ CCCCEEEEEEEEEEE	20.48	30576142
2499	Phosphorylation	NLGSGIASIRSEPLN ECCCCEEEECCCCCE	19.33	24719451
2667	Phosphorylation	HHCSRGATCISLPHG CCCCCCCEEEECCCC	17.13	-
2670	Phosphorylation	SRGATCISLPHGYTC CCCCEEEECCCCEEE	37.69	-
2675	Phosphorylation	CISLPHGYTCFCPLG EEECCCCEEEECCCC	9.41	-
2726	Phosphorylation	SFRSNELSWMSFASF CCCCCCCCEEEEEEE	17.98	25262027
2729	Phosphorylation	SNELSWMSFASFHVR CCCCCEEEEEEEEEE	16.05	29116813
2732	Phosphorylation	LSWMSFASFHVRKKT CCEEEEEEEEEECCC	17.55	29116813
2802	Phosphorylation	QKVTINGSTWHIIKA EEEEECCCEEEEEEC	24.68	29496907
2985	Phosphorylation	AKFMGNSYIKYIDPN EEECCCCEEEEECCC	12.87	18083107
2988	Phosphorylation	MGNSYIKYIDPNYRM CCCCEEEEECCCCCE	10.86	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EYS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EYS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EYS_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EYS_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 602772: Retinitis pigmentosa 25 (RP25)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.