EXOC4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOC4_RAT
• UniProt AC: Q62824
• Protein Name: Exocyst complex component 4
• Gene Name: Exoc4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 975
• Subcellular Localization: Midbody, Midbody ring . Cell projection . Colocalizes with CNTRL/centriolin at the midbody ring (By similarity). Localizes at the leading edge of migrating cells (PubMed:21658605).
• Protein Description: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
• Protein Sequence: MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIEELHRHLYIKSTSRVVQRNKEKGKMSSHGKDASPGPLIDVSNISTPRKFLDATQYSAAGSSSVREMNLQDIKEDLDCDPEENSTLFMGILIQGLARLKKIPETVKAIKERLEQELKQIVKRSTTQVADSAYQRGESLTVDNQPRLLLELLELLFDKFNAVASAHSIVLGYLQDSVGTQPTQQEEIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCLLREFLTIYIKNIFLNQVLTEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLMNLMHDLSAYSDQFLNMVCVKLQEYKDTCSTAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWTNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLAGRTKSAFSSLSASQMLSPAQESHVNMDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAMEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGDQTTQNTRLQRLKEIICEQAAIKQATKDKKITTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAEAAGGK ------CCCCCCCCC	17.63	-
9	Acetylation	AAEAAGGKYRSTVSK CCCCCCCCCCCCCCC	36.25	22902405
30	Phosphorylation	LLISVIRTLSTSDDV CHHEHHHHCCCCCCC	17.59	23984901
32	Phosphorylation	ISVIRTLSTSDDVED HEHHHHCCCCCCCCH	25.83	29779826
33	Phosphorylation	SVIRTLSTSDDVEDR EHHHHCCCCCCCCHH	39.01	28432305
34	Phosphorylation	VIRTLSTSDDVEDRE HHHHCCCCCCCCHHH	28.56	28432305
219	Phosphorylation	NKEKGKMSSHGKDAS HHHCCCCCCCCCCCC	23.75	27097102
220	Phosphorylation	KEKGKMSSHGKDASP HHCCCCCCCCCCCCC	32.53	27097102
226	Phosphorylation	SSHGKDASPGPLIDV CCCCCCCCCCCCEEC	40.29	28689409
234	Phosphorylation	PGPLIDVSNISTPRK CCCCEECCCCCCCHH	25.38	25575281
237	Phosphorylation	LIDVSNISTPRKFLD CEECCCCCCCHHHHC	36.29	28689409
238	Phosphorylation	IDVSNISTPRKFLDA EECCCCCCCHHHHCC	24.26	27097102
248	Phosphorylation	KFLDATQYSAAGSSS HHHCCCCCCCCCCCC	8.91	24972320
298	Acetylation	KKIPETVKAIKERLE CCCHHHHHHHHHHHH	52.38	22902405
407	Phosphorylation	EYLDMKNTRTASEPS HHHCCCCCCCCCCCC	24.71	25575281
409	Phosphorylation	LDMKNTRTASEPSAQ HCCCCCCCCCCCCHH	32.28	25575281
411	Phosphorylation	MKNTRTASEPSAQLS CCCCCCCCCCCHHCC	49.80	25575281
414	Phosphorylation	TRTASEPSAQLSYAS CCCCCCCCHHCCHHH	25.29	25575281
418	Phosphorylation	SEPSAQLSYASTGRE CCCCHHCCHHHCCHH	13.43	25575281
419	Phosphorylation	EPSAQLSYASTGREF CCCHHCCHHHCCHHH	17.11	25575281
421	Phosphorylation	SAQLSYASTGREFAA CHHCCHHHCCHHHHH	24.14	25575281
422	Phosphorylation	AQLSYASTGREFAAF HHCCHHHCCHHHHHH	31.89	25575281
469	Phosphorylation	RRELYSRSGELQGGP HHHHHHHCCCCCCCC	30.58	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOC4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOC4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOC4_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of EXOC4_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.