dbPTM

EXOC3_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EXOC3_RAT
UniProt AC	Q62825
Protein Name	Exocyst complex component 3
Gene Name	Exoc3
Organism	Rattus norvegicus (Rat).
Sequence Length	755
Subcellular Localization	Cytoplasm . Cytoplasm, perinuclear region . Cell projection, growth cone . Midbody . Golgi apparatus . Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (PubMed:
Protein Description	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
Protein Sequence	MCKDSACFSTMKETDLEAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMCEQYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFAVLDRTVTTRIEGTQADTRESDKMWLVRHLEIIRKYVLDDLVIAKNLLVQCFPPHYDIFKNLLSMYHQALSIRMQDLASEDLEANEIVSLLTWVLNTYTSAEMMGNVELAPEVDVNALEPLLSPNVVSELLDTYMSTLTSNIIAWLRKALETDKKDWSKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVLCLQQMNSFLSRYKEEAQLYKEEHLRNRQHPHCYVQYMVAIINNCQTFKESIISLKRKYLKPETEESLCQSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHLNELMTKKWMLGSNAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSAEERKEGAEKMVREAEQLRFLFRKLASGFGEDADGHCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLALRGDASRDMKQTIMETLEQGPMQASPNYVPIFQEIVVPSLNVAKLLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Acetylation	QRPDQLDKVEQYRRR CCHHHHHHHHHHHHH	57.15	22902405
99	Phosphorylation	VSKDWRQSINTIESL HCHHHHHHHHHHHHH	14.83	24945867
102	Phosphorylation	DWRQSINTIESLKDV HHHHHHHHHHHHHCH	25.18	24945867
105	Phosphorylation	QSINTIESLKDVKDA HHHHHHHHHHCHHHH	36.55	24945867
117	Phosphorylation	KDAVVQHSQLAAAVE HHHHHHHHHHHHHHH	15.14	24945867
170	Phosphorylation	DGLMCEQYRMDSGNK CCCEEEEEECCCCCC	5.89	25575281
174	Phosphorylation	CEQYRMDSGNKRDMT EEEEECCCCCCCCCE	34.62	25575281
294	Acetylation	RHLEIIRKYVLDDLV HHHHHHHHHCHHHHH	29.33	22902405
470	Phosphorylation	LCLQQMNSFLSRYKE HHHHHHHHHHHHHHH	23.40	30181290
473	Phosphorylation	QQMNSFLSRYKEEAQ HHHHHHHHHHHHHHH	31.39	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EXOC3_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EXOC3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EXOC3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of EXOC3_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EXOC3_RAT

Related Literatures of Post-Translational Modification