EVI5_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EVI5_DROME
• UniProt AC: Q9VYY9
• Protein Name: Ecotropic viral integration site 5 ortholog
• Gene Name: Evi5
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 807
• Subcellular Localization: Cytoplasm . Endosome .
• Protein Description: Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge..
• Protein Sequence: MTLTTTTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQWQRQLAENQRSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTRIREMETLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQHRYSDLESRMKDELMNVKIKFTEQSQTVAELKQEISRLETKNSEMLAEGELRANLDDSDKVRDLQDRLADMKAELTALKSRGKFPGAKLRSSSIQSIESTEIDFNDLNMVRRGSTELST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	PGEENLPTSEMDLLA CCCCCCCCCHHHHHH		22817900
58	Phosphorylation	SDAKSLNSLHSTHSR HCHHHHHHHHCCCCC		18327897
64	Phosphorylation	NSLHSTHSRKNSDTS HHHHCCCCCCCCCCC		19429919
534	Phosphorylation	KKTLRETTPDNSVAH HHHHHHCCCCCCHHH		22668510
746	Phosphorylation	LRANLDDSDKVRDLQ HHHCCCCHHHHHHHH		27626673
802	Phosphorylation	LNMVRRGSTELST-- HHCHHCCCCCCCC--		19429919
803	Phosphorylation	NMVRRGSTELST--- HCHHCCCCCCCC---		19429919
806	Phosphorylation	RRGSTELST------ HCCCCCCCC------		19429919
807	Phosphorylation	RGSTELST------- CCCCCCCC-------		19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EVI5_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EVI5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EVI5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EVG1_DROME	CG5280	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.