ETHE1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ETHE1_ARATH
• UniProt AC: Q9C8L4
• Protein Name: Persulfide dioxygenase ETHE1 homolog, mitochondrial
• Gene Name: GLY3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 294
• Subcellular Localization: Mitochondrion .
• Protein Description: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) gives rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. Required for normal endosperm development in seed, and thereby also required for normal embryo development..
• Protein Sequence: MVMTHFSRLRQLLLLQPKFLSSQPRPLRSPPPTFLRSVMGSSSSFSSSSSKLLFRQLFENESSTFTYLLADVSHPDKPALLIDPVDKTVDRDLKLIDELGLKLIYAMNTHVHADHVTGTGLLKTKLPGVKSVISKASGSKADLFLEPGDKVSIGDIYLEVRATPGHTAGCVTYVTGEGADQPQPRMAFTGDAVLIRGCGRTDFQEGSSDQLYESVHSQIFTLPKDTLIYPAHDYKGFEVSTVGEEMQHNPRLTKDKETFKTIMSNLNLSYPKMIDVAVPANMVCGLQDVPSQAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	SQPRPLRSPPPTFLR CCCCCCCCCCCCHHH		29654922
40	Acetylation	TFLRSVMGSSSSFSS CHHHHHHCCCCCCCC		22223895
253	Phosphorylation	MQHNPRLTKDKETFK HCCCCCCCCCHHHHH		24894044
261	Phosphorylation	KDKETFKTIMSNLNL CCHHHHHHHHHHCCC		25561503
264	Phosphorylation	ETFKTIMSNLNLSYP HHHHHHHHHCCCCCC		30291188
269	Phosphorylation	IMSNLNLSYPKMIDV HHHHCCCCCCCCEEE		19880383
270	Phosphorylation	MSNLNLSYPKMIDVA HHHCCCCCCCCEEEE		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ETHE1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ETHE1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ETHE1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ETHE1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.