| UniProt ID | ESYT3_HUMAN | |
|---|---|---|
| UniProt AC | A0FGR9 | |
| Protein Name | Extended synaptotagmin-3 | |
| Gene Name | ESYT3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 886 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein. Endoplasmic reticulum membrane Multi-pass membrane protein. Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 do |
|
| Protein Description | Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.. | |
| Protein Sequence | MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEWANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 126 | Phosphorylation | EWANKIISQTWPYLS HHHHHHHHHHHHHHH | 25.65 | 29978859 | |
| 128 | Phosphorylation | ANKIISQTWPYLSMI HHHHHHHHHHHHHHH | 22.93 | 29978859 | |
| 131 | Phosphorylation | IISQTWPYLSMIMES HHHHHHHHHHHHHHH | 11.72 | 29978859 | |
| 133 | Phosphorylation | SQTWPYLSMIMESKF HHHHHHHHHHHHHHH | 10.62 | 29978859 | |
| 138 | Phosphorylation | YLSMIMESKFREKLE HHHHHHHHHHHHHHC | 21.51 | 29978859 | |
| 179 | Phosphorylation | VNGVKAHTNTCNRRR CCCEEECCCCCCCCE | 36.76 | 29396449 | |
| 292 | Sumoylation | RVTVPVKKGLDLTNL CEEEEECCCCCCCCC | 66.01 | - | |
| 292 | Sumoylation | RVTVPVKKGLDLTNL CEEEEECCCCCCCCC | 66.01 | - | |
| 338 | Phosphorylation | SDPYAKVSIGLQHFR CCCCCCCEEECHHHH | 15.38 | - | |
| 366 | Phosphorylation | EVFEFMVYEVPGQDL HHEEEEEEECCCCCE | 10.22 | 18452278 | |
| 390 | Phosphorylation | DRDDFLGSLQICLGD CHHHHHHHHHHHHHH | 21.17 | 18452278 | |
| 400 | Phosphorylation | ICLGDVMTNRVVDEW HHHHHHHHCCEEEEE | 21.52 | 18452278 | |
| 611 | Phosphorylation | LLIKKVATNQGPKAQ EEEEEECCCCCCCCC | 30.94 | 23403867 | |
| 647 | Phosphorylation | VSRSTTTTTSATTVA CCCCCCCCCEEEEEE | 19.36 | - | |
| 684 | Phosphorylation | EPIGEKKSPATIFLT CCCCCCCCCCEEEEE | 30.73 | 28555341 | |
| 691 | Phosphorylation | SPATIFLTVPGPHSP CCCEEEEEECCCCCC | 17.57 | 33259812 | |
| 697 | Phosphorylation | LTVPGPHSPGPIKSP EEECCCCCCCCCCCC | 34.38 | 25849741 | |
| 703 | Phosphorylation | HSPGPIKSPRPMKCP CCCCCCCCCCCCCCC | 27.19 | 24719451 | |
| 724 | Phosphorylation | PPKRLAPSMSSLNSL CHHHHCCCHHHHHHH | 26.20 | 22210691 | |
| 730 | Phosphorylation | PSMSSLNSLASSCFD CCHHHHHHHHHHHCH | 30.52 | 22210691 | |
| 742 | Phosphorylation | CFDLADISLNIEGGD HCHHHHEEEEECCCC | 18.86 | 22210691 | |
| 845 | Phosphorylation | LDVAVKNSRPLGSHR CCEEECCCCCCCCHH | 29.56 | 24719451 | |
| 850 | Phosphorylation | KNSRPLGSHRRKELG CCCCCCCCHHHHHHH | 22.85 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ESYT3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ESYT3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ESYT3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ESYT3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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