EST3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EST3A_MOUSE
• UniProt AC: Q63880
• Protein Name: Carboxylesterase 3A
• Gene Name: Ces3a
• Organism: Mus musculus (Mouse).
• Sequence Length: 571
• Subcellular Localization: Endoplasmic reticulum lumen. Microsomal membrane, lumen of endoplasmic reticulum.
• Protein Description: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs..
• Protein Sequence: MTNMETTAQAGSSVRVWMACLLLIFPTTVIGPKVTQPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWSEAQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISYTVNDSFFPQRPQKLLANKQFPTVPYLLGVTNHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHMQLPPEIMPTVIDEYLDNGSDESATRYALQELLGDITLVIPTLIFSKYLQDAGCPVFLYEFQHTPSSFAKFKPAWVKADHSSENAFVFGGPFLTDESSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPPWPQLNQLEQYLEIGLEPRTGVKLKKGRLQFWTETLPRKIQEWHREQRSRKVPEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTNMETTAQ ------CCCHHHHHH	43.18	28576409
54	Succinylation	RGRQVGVKDTDRMVN CCEECCCCCHHHHHH	49.32	23954790
54	Acetylation	RGRQVGVKDTDRMVN CCEECCCCCHHHHHH	49.32	23201123
100	S-palmitoylation	ASINPPMCLQDVERM CCCCCCCCHHHHHHH	3.68	28526873
100	S-nitrosylation	ASINPPMCLQDVERM CCCCCCCCHHHHHHH	3.68	22178444
117	Ubiquitination	SRFTLNEKMKIFPIS CCEECCCCEEEEECC	44.41	-
117	Succinylation	SRFTLNEKMKIFPIS CCEECCCCEEEEECC	44.41	23954790
117	Acetylation	SRFTLNEKMKIFPIS CCEECCCCEEEEECC	44.41	23954790
127	S-palmitoylation	IFPISEDCLTLNIYS EEECCCCCEEEEECC	2.47	28526873
207	Ubiquitination	RGFLDVVAALRWVQG CCHHHHHHHHHHHHC	10.71	27667366
302	Acetylation	CLLQKEGKDLITKKN HHHHHCCCCCEECCC	50.91	23201123
307	Acetylation	EGKDLITKKNVNISY CCCCCEECCCEEEEE	35.04	23201123
311	N-linked_Glycosylation	LITKKNVNISYTVND CEECCCEEEEEEECC	27.21	-
317	N-linked_Glycosylation	VNISYTVNDSFFPQR EEEEEEECCCCCCCC	31.26	-
366	Phosphorylation	LDKMEHLSQEDLLEN HHHHHHCCHHHHHHC	33.17	29472430
398	N-linked_Glycosylation	VIDEYLDNGSDESAT HHHHHHHCCCCHHHH	49.63	-
405	Ubiquitination	NGSDESATRYALQEL CCCCHHHHHHHHHHH	33.23	27667366
434	S-palmitoylation	KYLQDAGCPVFLYEF HHHHHCCCCEEEEEE	2.52	28526873
439	Phosphorylation	AGCPVFLYEFQHTPS CCCCEEEEEECCCCH	11.84	-
450	Acetylation	HTPSSFAKFKPAWVK CCCHHHHCCCCEEEE	52.49	23864654
452	Ubiquitination	PSSFAKFKPAWVKAD CHHHHCCCCEEEECC	32.87	27667366
452	Acetylation	PSSFAKFKPAWVKAD CHHHHCCCCEEEECC	32.87	23864654
461	Phosphorylation	AWVKADHSSENAFVF EEEECCCCCCCEEEE	39.64	23984901
462	Phosphorylation	WVKADHSSENAFVFG EEECCCCCCCEEEEC	31.30	23984901
550	Phosphorylation	RLQFWTETLPRKIQE CEEEEHHHHHHHHHH	34.39	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EST3A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EST3A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EST3A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EST3A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.