EST2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EST2_HUMAN
• UniProt AC: O00748
• Protein Name: Cocaine esterase
• Gene Name: CES2
• Organism: Homo sapiens (Human).
• Sequence Length: 559
• Subcellular Localization: Endoplasmic reticulum lumen.
• Protein Description: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine..
• Protein Sequence: MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MRLHRLRAR ------CCHHHHHHH	38.92	-
5	Phosphorylation	---MRLHRLRARLSA ---CCHHHHHHHHHH	30.38	-
7	Phosphorylation	-MRLHRLRARLSAVA -CCHHHHHHHHHHHH	20.02	-
27	Pyrrolidone_carboxylic_acid	LLVRGQGQDSASPIR HHHHCCCCCCCCCCC	33.33	-
27	Pyrrolidone_carboxylic_acid	LLVRGQGQDSASPIR HHHHCCCCCCCCCCC	33.33	-
38	Phosphorylation	SPIRTTHTGQVLGSL CCCCCCCCCCEEEEE	27.50	-
41	Phosphorylation	RTTHTGQVLGSLVHV CCCCCCCEEEEEEEE	7.46	-
44	Phosphorylation	HTGQVLGSLVHVKGA CCCCEEEEEEEECCC	24.06	23312004
58	Phosphorylation	ANAGVQTFLGIPFAK CCCCCEEECCCCCCC	3.08	-
60	Phosphorylation	AGVQTFLGIPFAKPP CCCEEECCCCCCCCC	22.72	-
61	Phosphorylation	GVQTFLGIPFAKPPL CCEEECCCCCCCCCC	2.49	-
64	Phosphorylation	TFLGIPFAKPPLGPL EECCCCCCCCCCCCC	20.35	-
108	Phosphorylation	AVESEFLSQFNMTFP HHHHHHHHHCCCCCC	37.74	-
111	N-linked_Glycosylation	SEFLSQFNMTFPSDS HHHHHHCCCCCCCCC	22.43	19159218
116	Phosphorylation	QFNMTFPSDSMSEDC HCCCCCCCCCCCCCE	37.82	21601212
175	N-linked_Glycosylation	ENVVVVIIQYRLGVL HCEEEEEEEHHHCCC	1.67	19159218
276	N-linked_Glycosylation	VISTVVANLSACDQV HHHHHHHHHHHCCCC	23.95	UniProtKB CARBOHYD
368	Phosphorylation	KEMDREASQAALQKM HHHHHHHHHHHHHHH	18.66	-
489	Acetylation	QLSRKMMKYWANFAR HHHHHHHHHHHHHHH	33.86	7308067
539	Acetylation	AHRLQFWKKALPQKI HHHHHHHHHHHHHHH	29.47	27178108
609	Ubiquitination	--------------------------------------------------------- ---------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EST2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EST2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EST2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EST2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-111, AND MASSSPECTROMETRY.
PubMed: 19159218