ESPN_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ESPN_RAT
• UniProt AC: Q63618
• Protein Name: Espin
• Gene Name: Espn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 837
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, stereocilium . Cell projection, microvillus. Cell junction.; Isoform 1: Cytoplasm, cytoskeleton. Cell junction. Isoform 1 localizes to parallel actin bundles of ectoplasmic specializations between neighboring
• Protein Description: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. [PubMed: 9763424 Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (By similarity]
• Protein Sequence: MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFEQDHDGATAMHFAASRGHTKVLSWLLLHGAEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLRTVQTLSLEHRVLSRDPSMDLEAKQPDSGMSSPNTTMSVQPPNFDLGSPTSTLSNYDSCSSSHSSSKGQRSTRGARSSDLQSYMDMLNPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPPPPPGYPAPNPPVGLHLDNIYMQTKNKLRHVEVDSLKKEPSSGDGYSGLRRQDSGLLRQDSELLLRHNTGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEAALLPGNHVHNGCSADSKASRELPPPPPPPPLPEALSSPPPAPPLPIEGAGAACGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGSGQPASQPESPQPAVSPGPSRARSPTPPASGPQPLLNGSIVPAPPATLAPGVHLDVEALIPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEEARLASLPAWRRDILRKKLEEEREQKRKEEERQKLEEIQRAKEQSEKLRTLGYDEAKLAPWQRQVILKKGEIPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
337	Phosphorylation	SLEHRVLSRDPSMDL CHHHHHHHCCCCCCC	31.60	22673903
341	Phosphorylation	RVLSRDPSMDLEAKQ HHHHCCCCCCCEECC	29.26	22673903
400	Phosphorylation	RSTRGARSSDLQSYM CCCCCCCHHHHHHHH	27.89	22673903
401	Phosphorylation	STRGARSSDLQSYMD CCCCCCHHHHHHHHH	36.47	22673903
497	Phosphorylation	SGLRRQDSGLLRQDS CCCHHCCCCCCCCCH	24.01	22673903
504	Phosphorylation	SGLLRQDSELLLRHN CCCCCCCHHHHHHCC	23.08	22673903
531	Phosphorylation	RSFSKQPSTGDYYRQ HHHCCCCCCHHHHHH	42.39	22673903
535	Phosphorylation	KQPSTGDYYRQLGRS CCCCCHHHHHHHCCC	11.24	-
631	Phosphorylation	TKSFNMMSPTGDNSE CCEEEECCCCCCCHH	14.45	-
663	Phosphorylation	KGLTTVFSGSGQPAS CCCEEEECCCCCCCC	27.93	28432305
665	Phosphorylation	LTTVFSGSGQPASQP CEEEECCCCCCCCCC	32.81	28432305
670	Phosphorylation	SGSGQPASQPESPQP CCCCCCCCCCCCCCC	53.61	28432305
674	Phosphorylation	QPASQPESPQPAVSP CCCCCCCCCCCCCCC	35.20	28432305
680	Phosphorylation	ESPQPAVSPGPSRAR CCCCCCCCCCCCCCC	26.67	12598619
684	Phosphorylation	PAVSPGPSRARSPTP CCCCCCCCCCCCCCC	44.48	28432305
688	Phosphorylation	PGPSRARSPTPPASG CCCCCCCCCCCCCCC	31.94	26022182
690	Phosphorylation	PSRARSPTPPASGPQ CCCCCCCCCCCCCCC	43.05	26022182
703	Phosphorylation	PQPLLNGSIVPAPPA CCCCCCCCEECCCCC	21.24	26022182
831	Acetylation	WQRQVILKKGEIPK- HHHHHHHHCCCCCC-	47.83	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ESPN_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ESPN_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ESPN_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAIP2_RAT	Baiap2	physical	12598619

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.