ERRFI_MOUSE - dbPTM
ERRFI_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ERRFI_MOUSE
UniProt AC Q99JZ7
Protein Name ERBB receptor feedback inhibitor 1
Gene Name Errfi1
Organism Mus musculus (Mouse).
Sequence Length 461
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein
Cytoplasmic side . Nucleus . Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.
Protein Description Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development..
Protein Sequence MSTAGVAAQDIRVPLKTGFLHNGQALGNMKSCWGSHSEFENNFLNIDPITMAYNLNSPAQEHLTTVGCAARSAPGSGHFFAECGPSPRSSLPPLVISPSESSGQREEDQVMCGFKKLSVNGVCTSTPPLTPIKSCPSPFPCAALCDRGSRPLPPLPISEDLCVDEADSEVELLTTSSDTDLLLEDSAPSDFKYDAPGRRSFRGCGQINYAYFDSPTVSVADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSDEDKPEVPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSANKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKYFKEAEETNPSTQIQPLPAACGMASATEKLASRMKIDMGSHGKRKHLSYVVSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSTAGVAAQ
------CCCCCCCCC		27.28-
31PhosphorylationQALGNMKSCWGSHSE
EECCCCCHHCCCCHH		12.3423984901
35PhosphorylationNMKSCWGSHSEFENN
CCCHHCCCCHHHCCC		10.1923984901
37PhosphorylationKSCWGSHSEFENNFL
CHHCCCCHHHCCCCC		45.7523984901
72PhosphorylationTVGCAARSAPGSGHF
HCCHHHCCCCCCCCC		33.8026824392
86PhosphorylationFFAECGPSPRSSLPP
CCHHCCCCCCCCCCC		20.4429514104
89PhosphorylationECGPSPRSSLPPLVI
HCCCCCCCCCCCEEE		39.3429472430
90PhosphorylationCGPSPRSSLPPLVIS
CCCCCCCCCCCEEEC		46.2929472430
97PhosphorylationSLPPLVISPSESSGQ
CCCCEEECCCCCCCC		18.2029472430
118PhosphorylationMCGFKKLSVNGVCTS
EECCEEEEECCEECC		23.5525619855
124PhosphorylationLSVNGVCTSTPPLTP
EEECCEECCCCCCCC		32.9825521595
125PhosphorylationSVNGVCTSTPPLTPI
EECCEECCCCCCCCC		33.5127087446
126PhosphorylationVNGVCTSTPPLTPIK
ECCEECCCCCCCCCC		15.6925521595
130PhosphorylationCTSTPPLTPIKSCPS
ECCCCCCCCCCCCCC		28.8325521595
134PhosphorylationPPLTPIKSCPSPFPC
CCCCCCCCCCCCCCH		31.7925777480
137PhosphorylationTPIKSCPSPFPCAAL
CCCCCCCCCCCHHHH		43.4222942356
200PhosphorylationYDAPGRRSFRGCGQI
CCCCCCCCCCCCCCE		20.2423984901
209PhosphorylationRGCGQINYAYFDSPT
CCCCCEEEEEECCCC		12.3323984901
211PhosphorylationCGQINYAYFDSPTVS
CCCEEEEEECCCCEE		9.5023984901
214PhosphorylationINYAYFDSPTVSVAD
EEEEEECCCCEEHHH		16.7525619855
216PhosphorylationYAYFDSPTVSVADLS
EEEECCCCEEHHHHC		29.3925619855
218PhosphorylationYFDSPTVSVADLSCA
EECCCCEEHHHHCCC		17.6725619855
249PhosphorylationSHRRLRRSHSGPAGS
HHHHHHHHCCCCCCC		18.6427087446
251PhosphorylationRRLRRSHSGPAGSFN
HHHHHHCCCCCCCCC		47.9527087446
256PhosphorylationSHSGPAGSFNKPAIR
HCCCCCCCCCCCEEE		27.9625619855
265PhosphorylationNKPAIRISSCTHRAS
CCCEEEEECCCCCCC		14.9825777480
266PhosphorylationKPAIRISSCTHRASP
CCEEEEECCCCCCCC		22.2125777480
268PhosphorylationAIRISSCTHRASPSS
EEEEECCCCCCCCCC		19.1517242355
272PhosphorylationSSCTHRASPSSDEDK
ECCCCCCCCCCCCCC		25.8525521595
274PhosphorylationCTHRASPSSDEDKPE
CCCCCCCCCCCCCCC		48.1825521595
275PhosphorylationTHRASPSSDEDKPEV
CCCCCCCCCCCCCCC		48.6921082442
301PhosphorylationKPDYRRWSAEVTSNT
CCCHHHCEEEECCCC		16.8525521595
305PhosphorylationRRWSAEVTSNTYSDE
HHCEEEECCCCCCCC		14.0425777480
306PhosphorylationRWSAEVTSNTYSDED
HCEEEECCCCCCCCC		32.1425777480
308PhosphorylationSAEVTSNTYSDEDRP
EEEECCCCCCCCCCC		24.9525777480
309PhosphorylationAEVTSNTYSDEDRPP
EEECCCCCCCCCCCC		20.5525777480
310PhosphorylationEVTSNTYSDEDRPPK
EECCCCCCCCCCCCC		32.2729472430
325PhosphorylationVPPREPLSRSNSRTP
CCCCCCCCCCCCCCC		44.3626824392
327PhosphorylationPREPLSRSNSRTPSP
CCCCCCCCCCCCCCC		35.4624719451
329PhosphorylationEPLSRSNSRTPSPKS
CCCCCCCCCCCCCCC		38.4827149854
331PhosphorylationLSRSNSRTPSPKSLP
CCCCCCCCCCCCCCH		28.1223140645
333PhosphorylationRSNSRTPSPKSLPSY
CCCCCCCCCCCCHHH		44.3327149854
336PhosphorylationSRTPSPKSLPSYLNG
CCCCCCCCCHHHHCC		49.2325521595
339PhosphorylationPSPKSLPSYLNGVMP
CCCCCCHHHHCCCCC		47.7723984901
340PhosphorylationSPKSLPSYLNGVMPP
CCCCCHHHHCCCCCC		11.4023984901
367PhosphorylationSKALQRQSSEGSANK
HHHHHHHCCCCCCCC		32.3327087446
368PhosphorylationKALQRQSSEGSANKV
HHHHHHCCCCCCCCC		37.3222324799
371PhosphorylationQRQSSEGSANKVPCI
HHHCCCCCCCCCCEE		25.3125521595
389PhosphorylationIENGKKVSSTHYYLL
EECCEECEECEEEEC		38.1029472430
390PhosphorylationENGKKVSSTHYYLLP
ECCEECEECEEEECC		23.3829472430
391PhosphorylationNGKKVSSTHYYLLPE
CCEECEECEEEECCC		13.3429472430
393PhosphorylationKKVSSTHYYLLPERP
EECEECEEEECCCCC		8.9030352176
394PhosphorylationKVSSTHYYLLPERPP
ECEECEEEECCCCCC		8.3117242355
460PhosphorylationKHLSYVVSP------
CCEEEEECC------		18.1727087446
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ERRFI_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ERRFI_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ERRFI_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ERBB2_HUMANERBB2physical
11003669
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ERRFI_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-126; THR-130 ANDSER-272, AND MASS SPECTROMETRY.

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