dbPTM

ERN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ERN1_MOUSE
UniProt AC	Q9EQY0
Protein Name	Serine/threonine-protein kinase/endoribonuclease IRE1 {ECO:0000305}
Gene Name	Ern1 {ECO:0000312\|MGI:MGI:1930134}
Organism	Mus musculus (Mouse).
Sequence Length	977
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type I membrane protein .
Protein Description	Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). [PubMed: 11850408]
Protein Sequence	MPARWLLLLLALLLPPPGPGSFGRTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQGEVLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINIVGQTSDNTPTTVSQDVEEKLARAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSVHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLFQTYYWHEPTEPQPPVIPYAL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
178	N-linked_Glycosylation	KTRELRWNATYFDYA CCCEEEEEEEECCHH	18.90	-
525	Phosphorylation	SESSGTSSPSPSPRA CCCCCCCCCCCCCCC	29.27	25338131
527	Phosphorylation	SSGTSSPSPSPRASN CCCCCCCCCCCCCCC	39.70	25338131
533	Phosphorylation	PSPSPRASNHSLHPS CCCCCCCCCCCCCCC	36.03	28418008
536	Phosphorylation	SPRASNHSLHPSSSA CCCCCCCCCCCCCCC	32.40	28418008
541	Phosphorylation	NHSLHPSSSASRAGT CCCCCCCCCCCCCCC	34.08	30352176
542	Phosphorylation	HSLHPSSSASRAGTS CCCCCCCCCCCCCCC	34.30	30352176
548	Phosphorylation	SSASRAGTSPSLEQD CCCCCCCCCCCCCCC	36.16	30635358
549	Phosphorylation	SASRAGTSPSLEQDD CCCCCCCCCCCCCCC	16.15	30635358
551	Phosphorylation	SRAGTSPSLEQDDED CCCCCCCCCCCCCCC	44.28	30635358
607	Phosphorylation	RILPECFSFADREVQ HHHHHHHHHHHHHHH	31.05	29899451
706	Ubiquitination	PNAHGRIKAMISDFG CCCCHHHHHHHCCCC	30.46	-
724	Phosphorylation	KLAVGRHSFSRRSGV HHHCCCCCCCCCCCC	24.45	-
729	Phosphorylation	RHSFSRRSGVPGTEG CCCCCCCCCCCCCCC	42.93	-
811	Ubiquitination	IARELIEKMIAMDPQ HHHHHHHHHHHCCCC	28.72	-
871	Ubiquitination	RGGRAVVKMDWRENI HCCEEEEEECHHHCE	25.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
724	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
724	S	Phosphorylation	Kinase	PKACA	P05132	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Syvn1	Q9DBY1	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ERN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ERN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ERN1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ERN1_MOUSE

Related Literatures of Post-Translational Modification