ERMP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERMP1_RAT
• UniProt AC: Q6UPR8
• Protein Name: Endoplasmic reticulum metallopeptidase 1 {ECO:0000305}
• Gene Name: Ermp1 {ECO:0000250|UniProtKB:Q7Z2K6}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 898
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures..
• Protein Sequence: MEWSSESAAVRRHRGTAERREGQAAASHPQREASAQEDARGGGRMRGRTESGGESRGAKTALSEARTALALALYLLALRALVQLSLQRLVLSRTSGLQGEFDARQARVYLEHITAIGPRTTGSAENEILTVQYLLEQITLIEEQSNSLHRISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPQDGAKYAVLANCHFDSVANSPGASDDAVSCAVMLEVLRVMAASPEPLQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKYLATSDMLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGRKLLRPNHSNSNYVRDFLCGLGITFISWFTSLVTVLIIAVFVSLIGQSLSWYNYFYIAVCLYGTATVAKIILIHTLAKRFYYVNASDLYLGELFFDTSLFVHCGFLVALTAQGFCSAFMSAVWVAFPLLTKLCVYKDFKKHGAKGRFIALYLLGMFIPYLYGLYLIWAVFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGAFFPYSSNPDSPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHIPEINDTIRAHCEENAPLCGFPWYLPVHFLIRKNWYLPAPEISPRNPAHFRLVSKEKMPWDSIKLTFEATGPSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWQFWIEVQVSEEQPEGMVTVAIAAHYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEWSSESA -------CCCCCHHH	12.28	-
34	Phosphorylation	SHPQREASAQEDARG CCCHHHHHHCCCCCC	26.23	22108457
51	Phosphorylation	RMRGRTESGGESRGA CCCCCCCCCCCCHHH	52.03	28551015
176	N-linked_Glycosylation	GFTSYYDNITNVVVK CCCCCCCCCEEEEEE	27.19	-
724	N-linked_Glycosylation	TPHIPEINDTIRAHC CCCCCCCCHHHHHHH	38.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERMP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERMP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERMP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ERMP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.