ERIC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERIC1_HUMAN
• UniProt AC: Q86X53
• Protein Name: Glutamate-rich protein 1
• Gene Name: ERICH1
• Organism: Homo sapiens (Human).
• Sequence Length: 443
• Protein Sequence: MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDGVSRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPDHARVISAFFSYWITHILPEKSSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	RKHVFVEKVLQRLFP HCHHHHHHHHHHHCC	42.83	19608861
23	Phosphorylation	RLFPPVPSGQGKREP HHCCCCCCCCCCCCC	43.94	-
50	Acetylation	TSEKVSQKHAEPLTD CCHHHHHHHCCCCCC	36.96	25953088
56	Phosphorylation	QKHAEPLTDTGSETP HHHCCCCCCCCCCCC	42.08	21712546
58	Phosphorylation	HAEPLTDTGSETPTA HCCCCCCCCCCCCCC	37.05	29396449
60	Phosphorylation	EPLTDTGSETPTARR CCCCCCCCCCCCCCC	40.15	30576142
62	Phosphorylation	LTDTGSETPTARRLY CCCCCCCCCCCCCCC	27.86	29255136
64	Phosphorylation	DTGSETPTARRLYTA CCCCCCCCCCCCCCC	39.97	29255136
118	Acetylation	RRRIRKHKSKKKFKN HHHHHHHHCCCCCCC	67.99	20167786
121	Acetylation	IRKHKSKKKFKNPNN HHHHHCCCCCCCCCC	71.22	20167786
124	Ubiquitination	HKSKKKFKNPNNVLI HHCCCCCCCCCCHHH	79.12	-
155	Phosphorylation	QRQHTDGTTISKNKK HHHCCCCCCCCHHHH	24.62	-
158	Phosphorylation	HTDGTTISKNKKRKL CCCCCCCCHHHHHHH	28.25	-
229	Phosphorylation	GEEDVKDTREEDGAD CCCCCCCCCHHCCCC	33.97	24247654
238	Phosphorylation	EEDGADASEEDLTRA HHCCCCCCHHHHHHH	41.91	29255136
243	Phosphorylation	DASEEDLTRARQEEG CCCHHHHHHHHHHHC	34.31	23927012
254	Phosphorylation	QEEGADASEEDPTPA HHHCCCCCCCCCCCC	41.91	29255136
259	Phosphorylation	DASEEDPTPAGEEDV CCCCCCCCCCCHHHH	37.78	29255136
277	Phosphorylation	REEDGVDTIEEDLTR HHHHCCCCHHHHHHH	28.07	21815630
283	Phosphorylation	DTIEEDLTRAGEEDG CCHHHHHHHHCCCCC	30.69	27732954
302	Phosphorylation	EEDGADASEEDPTWA HHCCCCCCCCCCCCC	41.91	25137130
317	Phosphorylation	GEEEGADSGEEDGAD CCCCCCCCCCCCCCC	47.79	25137130
326	Phosphorylation	EEDGADASEEDDTIT CCCCCCCCCCCCCCC	41.91	25137130
339	Phosphorylation	ITNEKAHSILNFLKS CCHHHHHHHHHHHHH	33.36	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERIC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERIC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERIC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ERIC1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-12, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238 AND THR-277, ANDMASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.
PubMed: 19007248