| UniProt ID | ERG_MOUSE | |
|---|---|---|
| UniProt AC | P81270 | |
| Protein Name | Transcriptional regulator ERG | |
| Gene Name | Erg | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 486 | |
| Subcellular Localization | Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.. | |
| Protein Description | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.. | |
| Protein Sequence | MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQAPARVTIKMECNPSQVNGSRNSPDECSVNKGGKMVGSPDTVGMSYGSYMEEKHVPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHSHLTPQSKAAQPSPSAVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVSPHPPALPVTSSSFFASPNPYWNSPTGGIYPNTRLPASHMPSHLGTYY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Phosphorylation | TASSSSDYGQTSKMS CCCCCCCCCCCCCCC | 17.06 | 21082442 | |
| 51 | Phosphorylation | SSSDYGQTSKMSPRV CCCCCCCCCCCCCCC | 26.42 | 19060867 | |
| 55 | Phosphorylation | YGQTSKMSPRVPQQD CCCCCCCCCCCCCCH | 17.19 | 21183079 | |
| 80 | Phosphorylation | IKMECNPSQVNGSRN EEEECCHHHCCCCCC | 32.54 | 23984901 | |
| 85 | Phosphorylation | NPSQVNGSRNSPDEC CHHHCCCCCCCCCCC | 24.08 | 29472430 | |
| 88 | Phosphorylation | QVNGSRNSPDECSVN HCCCCCCCCCCCCCC | 32.39 | 25521595 | |
| 93 | Phosphorylation | RNSPDECSVNKGGKM CCCCCCCCCCCCCCC | 27.03 | 19060867 | |
| 103 | Phosphorylation | KGGKMVGSPDTVGMS CCCCCCCCCCCCCCC | 14.27 | 16141072 | |
| 106 | Phosphorylation | KMVGSPDTVGMSYGS CCCCCCCCCCCCHHH | 23.49 | 24719451 | |
| 222 | Phosphorylation | VDKALQNSPRLMHAR HHHHHHHCCCCCCCC | 9.84 | 25521595 | |
| 235 (in isoform 3) | Phosphorylation | - | 11.01 | 29899451 | |
| 252 (in isoform 2) | Phosphorylation | - | 20.95 | 29472430 | |
| 253 (in isoform 2) | Phosphorylation | - | 37.52 | 29472430 | |
| 260 (in isoform 2) | Phosphorylation | - | 47.06 | 27180971 | |
| 262 (in isoform 2) | Phosphorylation | - | 32.17 | 29472430 | |
| 268 | Phosphorylation | PPRRSAWTGHSHLTP CCCCCCCCCCCCCCC | 25.41 | 24719451 | |
| 277 | Phosphorylation | HSHLTPQSKAAQPSP CCCCCCCCCCCCCCC | 26.01 | 24719451 | |
| 283 | Phosphorylation | QSKAAQPSPSAVPKT CCCCCCCCCCCCCCC | 21.29 | 25521595 | |
| 349 | Phosphorylation | TNGEFKMTDPDEVAR CCCEEECCCHHHHHH | 44.99 | - | |
| 369 | Phosphorylation | KSKPNMNYDKLSRAL CCCCCCCHHHHHHHH | 12.04 | 30635358 | |
| 373 | Phosphorylation | NMNYDKLSRALRYYY CCCHHHHHHHHHHHH | 22.65 | 30635358 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERG_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERG_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERG_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SOX2_MOUSE | Sox2 | physical | 20211142 | |
| HS71B_MOUSE | Hspa1b | physical | 21183741 | |
| HSP7C_MOUSE | Hspa8 | physical | 21183741 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
