| UniProt ID | ER6L2_HUMAN | |
|---|---|---|
| UniProt AC | Q5T890 | |
| Protein Name | DNA excision repair protein ERCC-6-like 2 | |
| Gene Name | ERCC6L2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1561 | |
| Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mitochondrion. Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (RO | |
| Protein Description | May be involved in early DNA damage response.. | |
| Protein Sequence | MQPGSAPPPGRMDPSAPQPRAETSGKDIWHPGERCLAPSPDNGKLCEASIKSITVDENGKSFAVVLYADFQERKIPLKQLQEVKFVKDCPRNLIFDDEDLEKPYFPNRKFPSSSVAFKLSDNGDSIPYTINRYLRDYQREGTRFLYGHYIHGGGCILGDDMGLGKTVQVISFLAAVLHKKGTREDIENNMPEFLLRSMKKEPLSSTAKKMFLIVAPLSVLYNWKDELDTWGYFRVTVLHGNRKDNELIRVKQRKCEIALTTYETLRLCLDELNSLEWSAVIVDEAHRIKNPKARVTEVMKALKCNVRIGLTGTILQNNMKELWCVMDWAVPGLLGSGTYFKKQFSDPVEHGQRHTATKRELATGRKAMQRLAKKMSGWFLRRTKTLIKDQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVTLILQSSEPCTCRSGQKRRNCCYKTNSHGETVKTLYLSYLTVLQKVANHVALLQAASTSKQQETLIKRICDQVFSRFPDFVQKSKDAAFETLSDPKYSGKMKVLQQLLNHCRKNRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSTQDVNICLVSTMAGGLGLNFVGANVVVLFDPTWNPANDLQAIDRAYRIGQCRDVKVLRLISLGTVEEIMYLRQIYKQQLHCVVVGSENAKRYFEAVQGSKEHQGELFGIHNLFKFRSQGSCLTKDILEREGQVEAGIMTATTWLKEGPPAHKLEMPRQPDCQECRGTEQAAEPLAKEACDLCSDFSDEEPVGATGIKTAKNKAPDSSKASSSPGQLTLLQCGFSKLLETKCKAVEDSDGNTASDDESSDEQPTCLSTEAKDAGCEKNQDSLGTSKHQKLDNILNPKEKHIFYKSEKILEQNISSKSDEKKIKNTDKHCILQNVTESEDSDVICPTQYTTERFPDNSIRFKPPLEGSEDSETEHTVKTRNNDNSRNTDDKRNGIISKKLSPENTTLKSILKRKGTSDISDESDDIEISSKSRVRKRASSLRFKRIKETKKELHNSPKTMNKTNQVYAANEDHNSQFIDDYSSSDESLSVSHFSFSKQSHRPRTIRDRTSFSSKLPSHNKKNSTFIPRKPMKCSNEKVVNQEQSYESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLYISNPVNQKKKKVYHTNQTTFIIGETPKGIRRKQFEEMASYFNSSSVNEFAKHITNATSEERQKMLRDFYASQYPEVKEFFVDSVSQFNNSSFEKGEQRTRKKSDKRESLIKPRLSDSETLSFKDSTNKISQVCSLKTYKRKSVKFQNHISYREEVFFNDAETKKSPVSSTQEIDSGKNSQASEDTVTSRSLNSESETRERRLENTMKDQQDLTRTGISRKEPLLKLENKKIENPVLENTSVISLLGDTSILDDLFKSHGNSPTQLPKKVLSGPMEKAKQRPKDFWDILNEQNDESLSKLTDLAVIETLCEKAPLAAPFKRREEPATSLWKSNEKFLWKKFSPSDTDENATNTQSTT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 52 | Phosphorylation | LCEASIKSITVDENG CCEEEEEEEEECCCC | 24719451 | ||
| 54 | Phosphorylation | EASIKSITVDENGKS EEEEEEEEECCCCCE | 24719451 | ||
| 61 | Phosphorylation | TVDENGKSFAVVLYA EECCCCCEEEEEEEE | 24719451 | ||
| 102 | Ubiquitination | FDDEDLEKPYFPNRK CCHHHCCCCCCCCCC | 29967540 | ||
| 204 | Phosphorylation | SMKKEPLSSTAKKMF HCCCCCCCHHHHHHH | 24275569 | ||
| 205 | Phosphorylation | MKKEPLSSTAKKMFL CCCCCCCHHHHHHHE | 24275569 | ||
| 357 | Phosphorylation | HGQRHTATKRELATG CCCCCCHHHHHHHHH | 18669648 | ||
| 376 | Phosphorylation | QRLAKKMSGWFLRRT HHHHHHHCHHHHHHH | 24719451 | ||
| 400 | Phosphorylation | KKEDRMVYCSLTDFQ CCCCCEEEEEHHHHH | 26074081 | ||
| 402 | Phosphorylation | EDRMVYCSLTDFQKA CCCEEEEEHHHHHHH | 26074081 | ||
| 404 | Phosphorylation | RMVYCSLTDFQKAVY CEEEEEHHHHHHHHH | 26074081 | ||
| 411 | Phosphorylation | TDFQKAVYQTVLETE HHHHHHHHHHHHCCC | 26074081 | ||
| 413 | Phosphorylation | FQKAVYQTVLETEDV HHHHHHHHHHCCCCE | 26074081 | ||
| 417 | Phosphorylation | VYQTVLETEDVTLIL HHHHHHCCCCEEEEE | 26074081 | ||
| 505 | Ubiquitination | PDFVQKSKDAAFETL HHHHHHCHHHHHHHC | - | ||
| 673 | Ubiquitination | VVGSENAKRYFEAVQ EECCHHHHHHHHHHC | 29967540 | ||
| 725 | Phosphorylation | AGIMTATTWLKEGPP ECEEEHHHHHHHCCC | 30631047 | ||
| 766 | Phosphorylation | KEACDLCSDFSDEEP HHHHHHCCCCCCCCC | 23663014 | ||
| 769 | Phosphorylation | CDLCSDFSDEEPVGA HHHCCCCCCCCCCCC | 23663014 | ||
| 795 | Phosphorylation | DSSKASSSPGQLTLL CCCCCCCCCCCEEEE | 25627689 | ||
| 875 | Phosphorylation | PKEKHIFYKSEKILE HHHHHHHHCHHHHHH | 30622161 | ||
| 877 | Phosphorylation | EKHIFYKSEKILEQN HHHHHHCHHHHHHHH | 30622161 | ||
| 886 | Phosphorylation | KILEQNISSKSDEKK HHHHHHCCCCCCHHH | 30622161 | ||
| 939 | Phosphorylation | FKPPLEGSEDSETEH CCCCCCCCCCCCCCE | 29255136 | ||
| 942 | Phosphorylation | PLEGSEDSETEHTVK CCCCCCCCCCCEEEE | 29255136 | ||
| 944 | Phosphorylation | EGSEDSETEHTVKTR CCCCCCCCCEEEECC | 29255136 | ||
| 947 | Phosphorylation | EDSETEHTVKTRNND CCCCCCEEEECCCCC | 29255136 | ||
| 968 | Phosphorylation | DKRNGIISKKLSPEN CCCCCCCCCCCCCCC | 24719451 | ||
| 972 | Phosphorylation | GIISKKLSPENTTLK CCCCCCCCCCCCCHH | 30624053 | ||
| 976 | Phosphorylation | KKLSPENTTLKSILK CCCCCCCCCHHHHHH | 26270265 | ||
| 977 | Phosphorylation | KLSPENTTLKSILKR CCCCCCCCHHHHHHH | 26270265 | ||
| 980 | Phosphorylation | PENTTLKSILKRKGT CCCCCHHHHHHHHCC | 24719451 | ||
| 987 | Phosphorylation | SILKRKGTSDISDES HHHHHHCCCCCCCCC | 29523821 | ||
| 988 | Phosphorylation | ILKRKGTSDISDESD HHHHHCCCCCCCCCC | 29523821 | ||
| 991 | Phosphorylation | RKGTSDISDESDDIE HHCCCCCCCCCCCCE | 29523821 | ||
| 994 | Phosphorylation | TSDISDESDDIEISS CCCCCCCCCCCEECC | 29523821 | ||
| 1000 | Phosphorylation | ESDDIEISSKSRVRK CCCCCEECCHHHHHH | 30177828 | ||
| 1065 | Phosphorylation | SLSVSHFSFSKQSHR CCEEEEECCCCCCCC | 24719451 | ||
| 1095 | O-linked_Glycosylation | SHNKKNSTFIPRKPM CCCCCCCCCCCCCCC | 30379171 | ||
| 1105 | Phosphorylation | PRKPMKCSNEKVVNQ CCCCCCCCCCHHCCH | 24702127 | ||
| 1149 | Phosphorylation | SKAENHMSRWAAHDV HHHHHHHHHHHHHCH | 18669648 | ||
| 1174 | Phosphorylation | ANIAVCSSKTYKEKV CCEEEECCCCHHHHC | 18669648 | ||
| 1176 | Phosphorylation | IAVCSSKTYKEKVDA EEEECCCCHHHHCCC | 18669648 | ||
| 1177 | Phosphorylation | AVCSSKTYKEKVDAD EEECCCCHHHHCCCC | 29083192 | ||
| 1185 | Phosphorylation | KEKVDADTLPHTKKG HHHCCCCCCCCCCCC | 29083192 | ||
| 1189 | Phosphorylation | DADTLPHTKKGQQPS CCCCCCCCCCCCCCC | 29083192 | ||
| 1205 | Phosphorylation | GSISLPLYISNPVNQ CEECEEEEECCCCCC | 29759185 | ||
| 1250 | Phosphorylation | ASYFNSSSVNEFAKH HHHCCCHHHHHHHHH | 28985074 | ||
| 1262 | Phosphorylation | AKHITNATSEERQKM HHHHHCCCHHHHHHH | 28985074 | ||
| 1263 | Phosphorylation | KHITNATSEERQKML HHHHCCCHHHHHHHH | 28985074 | ||
| 1288 | Phosphorylation | VKEFFVDSVSQFNNS HHHHHHHCHHHCCCC | 29978859 | ||
| 1290 | Phosphorylation | EFFVDSVSQFNNSSF HHHHHCHHHCCCCCC | 29978859 | ||
| 1295 | Phosphorylation | SVSQFNNSSFEKGEQ CHHHCCCCCCCHHCH | 29978859 | ||
| 1296 | Phosphorylation | VSQFNNSSFEKGEQR HHHCCCCCCCHHCHH | 29978859 | ||
| 1313 | Phosphorylation | KKSDKRESLIKPRLS CCCHHCHHCCCCCCC | 24719451 | ||
| 1320 | Phosphorylation | SLIKPRLSDSETLSF HCCCCCCCCCCCEEC | 22777824 | ||
| 1322 | Phosphorylation | IKPRLSDSETLSFKD CCCCCCCCCCEECCC | 23186163 | ||
| 1324 | Phosphorylation | PRLSDSETLSFKDST CCCCCCCCEECCCCC | 23186163 | ||
| 1326 | Phosphorylation | LSDSETLSFKDSTNK CCCCCCEECCCCCCH | 24719451 | ||
| 1335 | Phosphorylation | KDSTNKISQVCSLKT CCCCCHHHHHHCCCC | 28270605 | ||
| 1339 | Phosphorylation | NKISQVCSLKTYKRK CHHHHHHCCCCCCCC | 28270605 | ||
| 1342 | Phosphorylation | SQVCSLKTYKRKSVK HHHHCCCCCCCCCCE | 28270605 | ||
| 1343 | Phosphorylation | QVCSLKTYKRKSVKF HHHCCCCCCCCCCEE | 28270605 | ||
| 1370 | Phosphorylation | NDAETKKSPVSSTQE CCCCCCCCCCCCCEE | 29255136 | ||
| 1373 | Phosphorylation | ETKKSPVSSTQEIDS CCCCCCCCCCEEECC | 29978859 | ||
| 1374 | Phosphorylation | TKKSPVSSTQEIDSG CCCCCCCCCEEECCC | 29978859 | ||
| 1375 | Phosphorylation | KKSPVSSTQEIDSGK CCCCCCCCEEECCCC | 29978859 | ||
| 1380 | Phosphorylation | SSTQEIDSGKNSQAS CCCEEECCCCCCCCC | 29978859 | ||
| 1384 | Phosphorylation | EIDSGKNSQASEDTV EECCCCCCCCCCCCH | 18669648 | ||
| 1387 | Phosphorylation | SGKNSQASEDTVTSR CCCCCCCCCCCHHHC | 18669648 | ||
| 1390 | Phosphorylation | NSQASEDTVTSRSLN CCCCCCCCHHHCCCC | 18669648 | ||
| 1392 | Phosphorylation | QASEDTVTSRSLNSE CCCCCCHHHCCCCCC | 29978859 | ||
| 1393 | Phosphorylation | ASEDTVTSRSLNSES CCCCCHHHCCCCCCH | 29978859 | ||
| 1395 | Phosphorylation | EDTVTSRSLNSESET CCCHHHCCCCCCHHH | 18669648 | ||
| 1418 | O-linked_Glycosylation | MKDQQDLTRTGISRK HHHHHHHHHHCCCCC | 55832997 | ||
| 1418 | Phosphorylation | MKDQQDLTRTGISRK HHHHHHHHHHCCCCC | 26074081 | ||
| 1420 | O-linked_Glycosylation | DQQDLTRTGISRKEP HHHHHHHHCCCCCCC | 55833003 | ||
| 1420 | Phosphorylation | DQQDLTRTGISRKEP HHHHHHHHCCCCCCC | 26074081 | ||
| 1423 | O-linked_Glycosylation | DLTRTGISRKEPLLK HHHHHCCCCCCCHHH | 55833007 | ||
| 1423 | Phosphorylation | DLTRTGISRKEPLLK HHHHHCCCCCCCHHH | 26074081 | ||
| 1462 | Phosphorylation | ILDDLFKSHGNSPTQ HHHHHHHHCCCCCCC | 29978859 | ||
| 1466 | Phosphorylation | LFKSHGNSPTQLPKK HHHHCCCCCCCCCHH | 29978859 | ||
| 1468 | Phosphorylation | KSHGNSPTQLPKKVL HHCCCCCCCCCHHHH | 29978859 | ||
| 1476 | Phosphorylation | QLPKKVLSGPMEKAK CCCHHHHCCHHHHHH | 29449344 | ||
| 1512 | Phosphorylation | TDLAVIETLCEKAPL HHHHHHHHHHHHCCC | 23882029 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ER6L2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ER6L2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ER6L2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ER6L2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615715 | Bone marrow failure syndrome 2 (BMFS2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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