EPN2_RAT - dbPTM
EPN2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EPN2_RAT
UniProt AC Q9Z1Z3
Protein Name Epsin-2
Gene Name Epn2
Organism Rattus norvegicus (Rat).
Sequence Length 583
Subcellular Localization Cytoplasm. In punctate structures throughout the cell and particularly concentrated in the region of the Golgi complex..
Protein Description Plays a role in the formation of clathrin-coated invaginations and endocytosis..
Protein Sequence MTTSSIRRQMKNIVNSYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVRFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSISHSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRDTVKVPKKKEVKACCKPGSHSQQTTLLDLMDALPSSGPVAQKTEPWSTGTPANQTNPWGGTVAPANISDPWPSFGTKPAASVDPWGVPTTASIQSVPKNSDPWAASQQPASDAGKTADAWGAAKPSPASGSFELFSNFNGTVKDDFSEFDNLRTSKKPAESGASVPPQDSRTTSPDLFESQSLTSASSKPSSARKTPESFLGPNAALVNLDSLVTKPAPPAQSLNPFLAPGAAAPAPVNPFQVNQPQPLTLNQLRGSPVLGSSASFGSGPGVETVAPMPSVAPHSALGATGSSLTPLGPTAMNMVGSMGIPPSAAQPAGTTNPFLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTTSSIRRQ
------CCHHHHHHH		35.0730181290
3Phosphorylation-----MTTSSIRRQM
-----CCHHHHHHHH		21.1230181290
4Phosphorylation----MTTSSIRRQMK
----CCHHHHHHHHH		18.0130181290
5Phosphorylation---MTTSSIRRQMKN
---CCHHHHHHHHHH		20.3030181290
163PhosphorylationQVATGVGSNQITFGR
HHHHCCCCCEEEECC		24.1327097102
170MethylationSNQITFGRGSSQPNL
CCEEEECCCCCCCCE		37.31-
172PhosphorylationQITFGRGSSQPNLSI
EEEECCCCCCCCEEE		25.1623712012
173PhosphorylationITFGRGSSQPNLSIS
EEECCCCCCCCEEEC		53.1023712012
192PhosphorylationEYGKAGGSPASYHGS
HHHCCCCCCCCCCCC		19.1723712012
195PhosphorylationKAGGSPASYHGSTSP
CCCCCCCCCCCCCCC		22.5023712012
196PhosphorylationAGGSPASYHGSTSPR
CCCCCCCCCCCCCCC		16.5927097102
199PhosphorylationSPASYHGSTSPRVSS
CCCCCCCCCCCCCCH		16.6427097102
200PhosphorylationPASYHGSTSPRVSSE
CCCCCCCCCCCCCHH		47.5527097102
201PhosphorylationASYHGSTSPRVSSEL
CCCCCCCCCCCCHHH		16.6527097102
205PhosphorylationGSTSPRVSSELEQAR
CCCCCCCCHHHHHHC		21.2630181290
206PhosphorylationSTSPRVSSELEQARP
CCCCCCCHHHHHHCC		43.2630181290
276PhosphorylationKACCKPGSHSQQTTL
CHHCCCCCCCCCCHH		28.6127097102
278PhosphorylationCCKPGSHSQQTTLLD
HCCCCCCCCCCHHHH		26.1927097102
281PhosphorylationPGSHSQQTTLLDLMD
CCCCCCCCHHHHHHH		16.2727097102
282PhosphorylationGSHSQQTTLLDLMDA
CCCCCCCHHHHHHHH		22.4527097102
383PhosphorylationAWGAAKPSPASGSFE
CCCCCCCCCCCCCEE		32.1827097102
386PhosphorylationAAKPSPASGSFELFS
CCCCCCCCCCEEEHH		38.0527097102
388PhosphorylationKPSPASGSFELFSNF
CCCCCCCCEEEHHCC		17.0427097102
427PhosphorylationASVPPQDSRTTSPDL
CCCCCCCCCCCCCCH		26.6927097102
429PhosphorylationVPPQDSRTTSPDLFE
CCCCCCCCCCCCHHH		35.2627097102
430PhosphorylationPPQDSRTTSPDLFES
CCCCCCCCCCCHHHC		36.8327097102
431PhosphorylationPQDSRTTSPDLFESQ
CCCCCCCCCCHHHCC		18.7927097102
437PhosphorylationTSPDLFESQSLTSAS
CCCCHHHCCCCCCCC		20.1025575281
439PhosphorylationPDLFESQSLTSASSK
CCHHHCCCCCCCCCC		42.7825403869
442PhosphorylationFESQSLTSASSKPSS
HHCCCCCCCCCCCCH		31.2925575281
444PhosphorylationSQSLTSASSKPSSAR
CCCCCCCCCCCCHHC		38.3725575281
445PhosphorylationQSLTSASSKPSSARK
CCCCCCCCCCCHHCC		48.5825575281
448PhosphorylationTSASSKPSSARKTPE
CCCCCCCCHHCCCCH		40.1325575281
449PhosphorylationSASSKPSSARKTPES
CCCCCCCHHCCCCHH		40.3925575281
453PhosphorylationKPSSARKTPESFLGP
CCCHHCCCCHHHCCC		27.0827097102
456PhosphorylationSARKTPESFLGPNAA
HHCCCCHHHCCCCCE		27.2927097102
514PhosphorylationTLNQLRGSPVLGSSA
CHHHCCCCCCCCCCC		12.8530240740
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EPN2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EPN2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EPN2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of EPN2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EPN2_RAT

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Related Literatures of Post-Translational Modification

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