EPC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPC2_MOUSE
• UniProt AC: Q8C0I4
• Protein Name: Enhancer of polycomb homolog 2
• Gene Name: Epc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 808
• Subcellular Localization: Nucleus.
• Protein Description: May play a role in transcription or DNA repair..
• Protein Sequence: MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVNYYNRLYKGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVRKRKNCRGPSLIPQIKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVEKRYHLGDYGGEILNEVKVNRSEKELYASPATLHNGNHHKVQECKTKHPHHLSLKEEASDVVRQKKKYPKKPKAEAGIAPQQPTPETLPVINKSDIKQYDFQSSDEDEFPQVLSPASEAEEENDPDGSCAFRRRAGCQYYAPRLDQANNHMCENSELADLDKLRYKHCLTTLTVPRRCIGFARRRIGRGGRVIMDRISTEHDPVLKQIDPEMLNGFSSSSQTIDFSSNFSRTNASSKPCENRLSLSEILSNIRSCRLQCFQPRLLNVQDIDSEECTSRKPGQTVSSKRVSAASVALLNTSKNGISVTGGITEEQFQTHQQQLVQMQRQQLAQLHQKQQSQHSSQQTHPKAQGSSTSDCMSKTLDSASAHFAASAVVSAPVPSRSEGSKEQNTGHNNMNGVVQPSGPSKTLYSTNMALSSSPGISAVQLVRTVGHTTTNHLIPALCTSSPQTLPMNNSCLTNAVHLNNVSVVSPVNVHINTRTSAPSPTALKLATVAASMDRVPKVTPSSAISSIARENHEPERLGLNGLAETTVAMEVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Acetylation	PLPIYRGKDMPDLND CCCCCCCCCCCCHHH	41.68	23806337
51	Phosphorylation	GMEKEEESEHHLQRA CCCCHHHCHHHHHHH	45.57	28059163
60	Phosphorylation	HHLQRAISAQQVFRE HHHHHHHHHHHHHHH	21.02	29176673
115	Phosphorylation	LDNEQPDYDMDSEDE CCCCCCCCCCCCCHH	21.61	26745281
119	Phosphorylation	QPDYDMDSEDETLLN CCCCCCCCCHHHHHH	40.07	26745281
123	Phosphorylation	DMDSEDETLLNRLNR CCCCCHHHHHHHHHH	49.20	24759943
383	Phosphorylation	DEFPQVLSPASEAEE CCCCCCCCCHHHHHH	21.40	24759943
386	Phosphorylation	PQVLSPASEAEEEND CCCCCCHHHHHHHCC	40.50	24759943
434	Phosphorylation	ADLDKLRYKHCLTTL CCHHHHHHCHHHCCC	18.60	20139300
552	Phosphorylation	TSRKPGQTVSSKRVS CCCCCCCCCCCHHHC	28.42	25367039
556	Acetylation	PGQTVSSKRVSAASV CCCCCCCHHHCHHHH	49.68	30985921
636	Phosphorylation	SKTLDSASAHFAASA HHHHHHHHHHHHHHH	26.65	28059163
642	Phosphorylation	ASAHFAASAVVSAPV HHHHHHHHHHEECCC	20.40	28059163
653	Phosphorylation	SAPVPSRSEGSKEQN ECCCCCCCCCCCCCC	51.12	30635358
656	Phosphorylation	VPSRSEGSKEQNTGH CCCCCCCCCCCCCCC	29.03	30635358
661	Phosphorylation	EGSKEQNTGHNNMNG CCCCCCCCCCCCCCC	39.24	30635358
673	Phosphorylation	MNGVVQPSGPSKTLY CCCCCCCCCCCCCEE	46.36	30635358
676	Phosphorylation	VVQPSGPSKTLYSTN CCCCCCCCCCEEECC	41.62	30635358
677	Acetylation	VQPSGPSKTLYSTNM CCCCCCCCCEEECCC	45.76	23236377
751	Phosphorylation	NVHINTRTSAPSPTA EEEECCCCCCCCCHH	27.48	30635358
755	Phosphorylation	NTRTSAPSPTALKLA CCCCCCCCCHHHHHH	34.30	27149854
757	Phosphorylation	RTSAPSPTALKLATV CCCCCCCHHHHHHHH	49.30	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EPC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.