ENTK_HUMAN - dbPTM
ENTK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ENTK_HUMAN
UniProt AC P98073
Protein Name Enteropeptidase
Gene Name TMPRSS15
Organism Homo sapiens (Human).
Sequence Length 1019
Subcellular Localization Membrane
Single-pass type II membrane protein .
Protein Description Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases..
Protein Sequence MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGSKRGISS
------CCCCCCCCC		53.85-
3Phosphorylation-----MGSKRGISSR
-----CCCCCCCCCC		30.9123403867
99PhosphorylationMIDEIFLSSNLKNEY
HHHHHHHCCCCCHHH		13.36-
100PhosphorylationIDEIFLSSNLKNEYK
HHHHHHCCCCCHHHC		48.61-
116N-linked_GlycosylationSRVLQFENGSIIVVF
CCEEEECCCCEEEEE		51.29UniProtKB CARBOHYD
147N-linked_GlycosylationLIQGLEANKSSQLVT
HHHHHHCCCCCCCEE		35.05UniProtKB CARBOHYD
179N-linked_GlycosylationSHLATPGNVSIECLP
CCCCCCCCEEEEECC		26.10UniProtKB CARBOHYD
328N-linked_GlycosylationESDYVGFNATYTAFN
CCCCCEEEEEEEECC		25.99UniProtKB CARBOHYD
335N-linked_GlycosylationNATYTAFNSSELNNY
EEEEEECCHHHHCCC		42.01UniProtKB CARBOHYD
388N-linked_GlycosylationNFDHTFGNASGFYIS
CCCCCCCCCCCEEEE		27.09UniProtKB CARBOHYD
411PhosphorylationQERVGLLSLPLDPTL
CCEEEEEECCCCCCC		32.7422210691
417PhosphorylationLSLPLDPTLEPACLS
EECCCCCCCCHHHHH		43.3422210691
424PhosphorylationTLEPACLSFWYHMYG
CCCHHHHHHHHHHHC		17.3927251275
427PhosphorylationPACLSFWYHMYGENV
HHHHHHHHHHHCCCE		3.7627251275
430PhosphorylationLSFWYHMYGENVHKL
HHHHHHHHCCCEEEE		14.1522210691
438PhosphorylationGENVHKLSINISNDQ
CCCEEEEEEEECCCC		20.5623403867
440N-linked_GlycosylationNVHKLSINISNDQNM
CEEEEEEEECCCCCC		28.41UniProtKB CARBOHYD
442PhosphorylationHKLSINISNDQNMEK
EEEEEEECCCCCCEE		29.8423403867
470N-linked_GlycosylationNYGQVTLNETVKFKV
CCEEEECCCEEEEEE		33.26UniProtKB CARBOHYD
503N-linked_GlycosylationSLTYGICNGSLYPEP
EECEEECCCCCCCCC		40.96UniProtKB CARBOHYD
534N-linked_GlycosylationPFELWEPNTTFSSTN
CCCCCCCCCCCCCCC		39.99UniProtKB CARBOHYD
596PhosphorylationDSLLLAVYTGPGPVK
CEEEEEEEECCCCHH		10.60-
597PhosphorylationSLLLAVYTGPGPVKD
EEEEEEEECCCCHHH		30.24-
613PhosphorylationFSTTNRMTVLLITND
CCCCCCEEEEEEECC		12.55-
618PhosphorylationRMTVLLITNDVLARG
CEEEEEEECCHHHCC		25.90-
630N-linked_GlycosylationARGGFKANFTTGYHL
HCCCCCCCCCCCCCC		35.07UniProtKB CARBOHYD
682N-linked_GlycosylationADCVRFFNGTTNNNG
CCEEEEECCCCCCCC		44.16UniProtKB CARBOHYD
706N-linked_GlycosylationWHTACAENWTTQISN
HEHHHHCCCCHHCCC		23.91UniProtKB CARBOHYD
725N-linked_GlycosylationLLGLGSGNSSKPIFP
HHCCCCCCCCCCCCC		44.82UniProtKB CARBOHYD
743PhosphorylationGPFVKLNTAPDGHLI
CCEEEECCCCCCCEE		50.43-
761PhosphorylationSQQCLQDSLIRLQCN
CHHHHHHHHHHHHCC		16.8524719451
846AcetylationAILGLHMKSNLTSPQ
EEEEEEECCCCCCCC		25.9918585145
848N-linked_GlycosylationLGLHMKSNLTSPQTV
EEEEECCCCCCCCHH		41.65UniProtKB CARBOHYD
850PhosphorylationLHMKSNLTSPQTVPR
EEECCCCCCCCHHHH		42.48-
851PhosphorylationHMKSNLTSPQTVPRL
EECCCCCCCCHHHHH		20.41-
887N-linked_GlycosylationMHLEFKVNYTDYIQP
EEEEEEECCCCCCCC		34.28UniProtKB CARBOHYD
909N-linked_GlycosylationQVFPPGRNCSIAGWG
CCCCCCCCCEECCCE		29.78UniProtKB CARBOHYD
949N-linked_GlycosylationQQQMPEYNITENMIC
HHHCCCCCCCCCEEE		32.80UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ENTK_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ENTK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ENTK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ENTK_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ENTK_HUMAN

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Related Literatures of Post-Translational Modification

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