ENPP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENPP5_HUMAN
• UniProt AC: Q9UJA9
• Protein Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 5
• Gene Name: ENPP5 {ECO:0000312|HGNC:HGNC:13717}
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Subcellular Localization: Secreted . Membrane ; Single-pass membrane protein .
• Protein Description: Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication..
• Protein Sequence: MTSKFLLVSFILAALSLSTTFSLQPDQQKVLLVSFDGFRWDYLYKVPTPHFHYIMKYGVHVKQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPIRNKSFSLDHMNIYDSKFWEEATPIWITNQRAGHTSGAAMWPGTDVKIHKRFPTHYMPYNESVSFEDRVAKIIEWFTSKEPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYLIQMLKKAKLWNTLNLIITSDHGMTQCSEERLIELDQYLDKDHYTLIDQSPVAAILPKEGKFDEVYEALTHAHPNLTVYKKEDVPERWHYKYNSRIQPIIAVADEGWHILQNKSDDFLLGNHGYDNALADMHPIFLAHGPAFRKNFSKEAMNSTDLYPLLCHLLNITAMPHNGSFWNVQDLLNSAMPRVVPYTQSTILLPGSVKPAEYDQEGSYPYFIGVSLGSIIVIVFFVIFIKHLIHSQIPALQDMHAEIAQPLLQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	QQKVLLVSFDGFRWD CCEEEEEEECCCCEE	20.00	26546556
42	Phosphorylation	FDGFRWDYLYKVPTP ECCCCEEEEEEECCC	12.64	23401153
44	Phosphorylation	GFRWDYLYKVPTPHF CCCEEEEEEECCCCH	12.05	23401153
48	Phosphorylation	DYLYKVPTPHFHYIM EEEEEECCCCHHHHH	32.17	23401153
53	Phosphorylation	VPTPHFHYIMKYGVH ECCCCHHHHHHCCCE	11.19	23401153
57	Phosphorylation	HFHYIMKYGVHVKQV CHHHHHHCCCEEEEE	13.65	24719451
65	Phosphorylation	GVHVKQVTNVFITKT CCEEEEEEEEEEECC	24.15	24719451
101	N-linked_Glycosylation	DMFDPIRNKSFSLDH CCCCCCCCCCCCCCC	45.07	UniProtKB CARBOHYD
133	Phosphorylation	TNQRAGHTSGAAMWP CCCCCCCCCCCCCCC	28.12	24400094
158	N-linked_Glycosylation	PTHYMPYNESVSFED CCCCCCCCCCCCHHH	29.24	UniProtKB CARBOHYD
162	Phosphorylation	MPYNESVSFEDRVAK CCCCCCCCHHHHHHH	32.00	24719451
267	Phosphorylation	HYTLIDQSPVAAILP CCEECCCCCCEEECC	20.00	24719451
287	Phosphorylation	DEVYEALTHAHPNLT HHHHHHHHCCCCCCE	24.86	24719451
292	N-linked_Glycosylation	ALTHAHPNLTVYKKE HHHCCCCCCEEEECC	38.18	UniProtKB CARBOHYD
294	Phosphorylation	THAHPNLTVYKKEDV HCCCCCCEEEECCCC	28.56	24719451
296	Phosphorylation	AHPNLTVYKKEDVPE CCCCCEEEECCCCCC	15.88	24719451
329	N-linked_Glycosylation	EGWHILQNKSDDFLL CCEEECCCCCCCEEC	42.21	UniProtKB CARBOHYD
362	N-linked_Glycosylation	HGPAFRKNFSKEAMN CCHHHHHCCCHHHCC	42.01	UniProtKB CARBOHYD
369	N-linked_Glycosylation	NFSKEAMNSTDLYPL CCCHHHCCCCCHHHH	49.13	UniProtKB CARBOHYD
382	N-linked_Glycosylation	PLLCHLLNITAMPHN HHHHHHHCCEECCCC	35.61	UniProtKB CARBOHYD
389	N-linked_Glycosylation	NITAMPHNGSFWNVQ CCEECCCCCCCCCHH	41.77	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENPP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENPP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENPP5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ENPP5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.