dbPTM

ENPL_CHICK - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ENPL_CHICK
UniProt AC	P08110
Protein Name	Endoplasmin
Gene Name	HSP90B1
Organism	Gallus gallus (Chicken).
Sequence Length	795
Subcellular Localization	Endoplasmic reticulum lumen.
Protein Description	Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity (By similarity)..
Protein Sequence	MKSAWALALACTLLLAASVTAEEVDVDATVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIKEIREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDKEKNMLHVTDTGIGMTKEELIKNLGTIAKSGTSEFLNKMTEMQDDSQSTSELIGQFGVGFYSAFLVADRVIVTSKHNNDTQHIWESDSNEFSVIDDPRGNTLGRGTTITLVLKEEASDYLELDTVKNLVKKYSQFINFPIYVWSSKTETVEEPVEEEEAKEEKEETDDNEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKTFSKEHDDPMAYIHFTAEGEVTFKSILFVPNSAPRGLFDEYGSKKSDFIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIAEEKYNDTFWKEFGTNVKLGVIEDHSNRTRLAKLLRFQSSHHESNLTSLDQYVERMKEKQDKIYFMAGASRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFEESEKSKESREALEKEFEPLLNWMKDKALKDKIEKAVLSQRLTQSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIKDMLRRVKENEDDKTVSDLAVVLFETATLRSGYMLPDTKEYGDRIERMLRLSLNIDLDAKVEEEPEEPEDAAEEAEQDEEEVDADAEDSETQKESTDVKDEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	N-linked_Glycosylation	AIQLDGLNASQIKEI HHHCCCCCHHHHHHH	42.97	-
106	N-linked_Glycosylation	FLRELISNASDALDK HHHHHHHCCHHHHHH	36.15	-
216	N-linked_Glycosylation	IVTSKHNNDTQHIWE EEEECCCCCCCCEEE	54.12	8166742
444	N-linked_Glycosylation	DSDDLPLNVSRETLQ CCCCCCCCCCHHHHH	27.98	-
480	N-linked_Glycosylation	KIAEEKYNDTFWKEF HHHHHHCCHHHHHHH	53.57	-
501	N-linked_Glycosylation	GVIEDHSNRTRLAKL EEEECCCCHHHHHHH	46.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ENPL_CHICK !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ENPL_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ENPL_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ENPL_CHICK !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ENPL_CHICK

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"A chicken transferrin binding protein is heat shock protein 108."; Hayes G.R., Himpler B.S., Weiner K.X.B., Lucas J.J.; Biochem. Biophys. Res. Commun. 200:65-70(1994). Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, ANDGLYCOSYLATION AT ASN-216.	8166742 [Abstract]