ENOA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENOA_RAT
• UniProt AC: P04764
• Protein Name: Alpha-enolase
• Gene Name: Eno1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 434
• Subcellular Localization: Cytoplasm. Cell membrane. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.
• Protein Description: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production..
• Protein Sequence: MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLDFKSPDDASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTNPKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSILKIHAR ------CCCEEEEEH	36.31	-
5	Acetylation	---MSILKIHAREIF ---CCCEEEEEHHHH	30.67	22902405
25	Phosphorylation	PTVEVDLYTAKGLFR CEEEEEEEECCCHHH	10.53	22108457
26	Phosphorylation	TVEVDLYTAKGLFRA EEEEEEEECCCHHHH	29.23	22673903
37	Phosphorylation	LFRAAVPSGASTGIY HHHHHCCCCCCCCHH	40.15	22108457
40	Phosphorylation	AAVPSGASTGIYEAL HHCCCCCCCCHHHHH	30.60	21738781
41	Phosphorylation	AVPSGASTGIYEALE HCCCCCCCCHHHHHH	27.37	22108457
44	Phosphorylation	SGASTGIYEALELRD CCCCCCHHHHHHCCC	9.11	29779826
54	Acetylation	LELRDNDKTRFMGKG HHCCCCCCCCCCCHH	48.10	22902405
60	Acetylation	DKTRFMGKGVSKAVE CCCCCCCHHHHHHHH	44.33	12016721
60	Succinylation	DKTRFMGKGVSKAVE CCCCCCCHHHHHHHH	44.33	-
60	Succinylation	DKTRFMGKGVSKAVE CCCCCCCHHHHHHHH	44.33	-
64	Ubiquitination	FMGKGVSKAVEHINK CCCHHHHHHHHHHHH	54.79	-
64	Acetylation	FMGKGVSKAVEHINK CCCHHHHHHHHHHHH	54.79	22902405
71	Acetylation	KAVEHINKTIAPALV HHHHHHHHCHHHHHH	40.48	22902405
79	Phosphorylation	TIAPALVSKKLNVVE CHHHHHHHHCCCCCC	25.56	29779826
80	Acetylation	IAPALVSKKLNVVEQ HHHHHHHHCCCCCCH	54.52	6590955
81	Succinylation	APALVSKKLNVVEQE HHHHHHHCCCCCCHH	37.47	26843850
81	Ubiquitination	APALVSKKLNVVEQE HHHHHHHCCCCCCHH	37.47	-
89	Succinylation	LNVVEQEKIDQLMIE CCCCCHHHHHHHHHC	51.80	-
89	Succinylation	LNVVEQEKIDQLMIE CCCCCHHHHHHHHHC	51.80	-
89	Acetylation	LNVVEQEKIDQLMIE CCCCCHHHHHHHHHC	51.80	22902405
126	Acetylation	CKAGAVEKGVPLYRH HHHCHHHCCCCCHHH	59.62	-
131	Nitration	VEKGVPLYRHIADLA HHCCCCCHHHHHHHC	8.28	-
157	Phosphorylation	FNVINGGSHAGNKLA EEEECCCCCCCCCHH	16.15	27097102
176	Phosphorylation	MILPVGASSFREAMR EEECCCHHHHHHHHH	24.87	25403869
177	Phosphorylation	ILPVGASSFREAMRI EECCCHHHHHHHHHH	27.99	25403869
193	Acetylation	AEVYHNLKNVIKEKY HHHHHHHHHHHHHHH	55.26	22902405
197	Acetylation	HNLKNVIKEKYGKDA HHHHHHHHHHHCCCC	43.82	22902405
199	Acetylation	LKNVIKEKYGKDATN HHHHHHHHHCCCCCC	55.06	22902405
202	Ubiquitination	VIKEKYGKDATNVGD HHHHHHCCCCCCCCC	40.89	-
202	Acetylation	VIKEKYGKDATNVGD HHHHHHCCCCCCCCC	40.89	22902405
205	Phosphorylation	EKYGKDATNVGDEGG HHHCCCCCCCCCCCC	40.34	22673903
221	Acetylation	APNILENKEALELLK CCCHHCCHHHHHHHH	34.68	22902405
228	Succinylation	KEALELLKSAIAKAG HHHHHHHHHHHHHCC	50.93	-
228	Other	KEALELLKSAIAKAG HHHHHHHHHHHHHCC	50.93	-
228	Succinylation	KEALELLKSAIAKAG HHHHHHHHHHHHHCC	50.93	-
228	Acetylation	KEALELLKSAIAKAG HHHHHHHHHHHHHCC	50.93	22902405
229	Phosphorylation	EALELLKSAIAKAGY HHHHHHHHHHHHCCC	25.52	28432305
233	N6-malonyllysine	LLKSAIAKAGYTDQV HHHHHHHHCCCCCEE	35.91	-
233	Acetylation	LLKSAIAKAGYTDQV HHHHHHHHCCCCCEE	35.91	-
233	Malonylation	LLKSAIAKAGYTDQV HHHHHHHHCCCCCEE	35.91	-
236	Nitration	SAIAKAGYTDQVVIG HHHHHCCCCCEEEEC	16.41	-
256	Acetylation	SEFYRAGKYDLDFKS HHHHHCCCCCCCCCC	34.31	22902405
257	Nitration	EFYRAGKYDLDFKSP HHHHCCCCCCCCCCC	22.33	-
257	Phosphorylation	EFYRAGKYDLDFKSP HHHHCCCCCCCCCCC	22.33	28551015
262	Acetylation	GKYDLDFKSPDDASR CCCCCCCCCCCCHHH	61.82	26302492
263	Phosphorylation	KYDLDFKSPDDASRY CCCCCCCCCCCHHHC	33.29	30411139
268	Phosphorylation	FKSPDDASRYITPDQ CCCCCCHHHCCCHHH	32.39	28551015
270	Phosphorylation	SPDDASRYITPDQLA CCCCHHHCCCHHHHH	13.47	28432305
272	Phosphorylation	DDASRYITPDQLADL CCHHHCCCHHHHHHH	16.33	22108457
281	Acetylation	DQLADLYKSFIKDYP HHHHHHHHHHHCCCC	46.30	22902405
281	Other	DQLADLYKSFIKDYP HHHHHHHHHHHCCCC	46.30	-
282	Phosphorylation	QLADLYKSFIKDYPV HHHHHHHHHHCCCCE	20.74	28432305
285	Acetylation	DLYKSFIKDYPVVSI HHHHHHHCCCCEEEC	49.55	-
287	Phosphorylation	YKSFIKDYPVVSIED HHHHHCCCCEEECCC	7.91	-
291	Phosphorylation	IKDYPVVSIEDPFDQ HCCCCEEECCCCCCC	22.09	-
330	Ubiquitination	TNPKRIAKAAGEKSC CCHHHHHHHCCCCCC	36.08	-
335	Acetylation	IAKAAGEKSCNCLLL HHHHCCCCCCCEEEE	60.43	-
343	Acetylation	SCNCLLLKVNQIGSV CCCEEEEEHHHCCCH	38.82	25786129
362	Phosphorylation	QACKLAQSNGWGVMV HHHHHHHHCCCEEEE	31.53	22673903
373	Phosphorylation	GVMVSHRSGETEDTF EEEEECCCCCCCCCH	35.24	22673903
406	Acetylation	CRSERLAKYNQILRI CCHHHHHHHHHHHHH	49.69	2915851
419	Phosphorylation	RIEEELGSKAKFAGR HHHHHHHHCHHHCCC	41.90	29779826
420	Ubiquitination	IEEELGSKAKFAGRS HHHHHHHCHHHCCCC	54.52	-
420	Succinylation	IEEELGSKAKFAGRS HHHHHHHCHHHCCCC	54.52	-
420	Malonylation	IEEELGSKAKFAGRS HHHHHHHCHHHCCCC	54.52	-
420	Acetylation	IEEELGSKAKFAGRS HHHHHHHCHHHCCCC	54.52	22902405
420	N6-malonyllysine	IEEELGSKAKFAGRS HHHHHHHCHHHCCCC	54.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENOA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENOA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENOA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ENOA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.