ENC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENC1_MOUSE
• UniProt AC: O35709
• Protein Name: Ectoderm-neural cortex protein 1
• Gene Name: Enc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 589
• Subcellular Localization: Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton. Interacts with the actin cytoskeleton.
• Protein Description: Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism (By similarity)..
• Protein Sequence: MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAMNWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEQYDPTTNKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWSVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	KSRASSGSINIYLFH CHHCCCCCEEEEEEE	17.89	28059163
275	Ubiquitination	EAIRCKLKILQNDGV HHHHHHHHHHCCCCC	27.19	22790023
406	Phosphorylation	ATGCLPASPSVSLKQ CCCCCCCCCCCCHHH	18.77	26824392
408	Phosphorylation	GCLPASPSVSLKQVE CCCCCCCCCCHHHHH	23.11	23984901
410	Phosphorylation	LPASPSVSLKQVEQY CCCCCCCCHHHHHEE	33.90	23984901
536	Phosphorylation	MSCHAVASGNKLYVV CEEEEEEECCEEEEE	35.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ENC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.