ENASE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENASE_HUMAN
• UniProt AC: Q8NFI3
• Protein Name: Cytosolic endo-beta-N-acetylglucosaminidase
• Gene Name: ENGASE
• Organism: Homo sapiens (Human).
• Sequence Length: 743
• Subcellular Localization: Cytoplasm, cytosol.
• Protein Description: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol..
• Protein Sequence: MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFREVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSSQRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTAHRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSLSLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGFFTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVALFAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEAVGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAVRLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLRPLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCRLGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRCFRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPVPKEGFRVPQAEWGRAVLLYSAPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAAAVTV -------CCCCEEEE	7.74	22814378
7	Phosphorylation	-MEAAAVTVTRSATR -CCCCEEEECHHHHH	16.07	23612710
9	Phosphorylation	EAAAVTVTRSATRRR CCCEEEECHHHHHHH	15.00	25106551
30	Phosphorylation	LAAPEAGTQEEQEDQ CCCCCCCCHHHHCCC	39.59	29970186
49	Phosphorylation	RRRRPGRSIKDEEEE CCCCCCCCCCHHHHH	39.65	23401153
57	Phosphorylation	IKDEEEETVFREVVS CCHHHHHHHHHHHHH	28.37	23312004
64	Phosphorylation	TVFREVVSFSPDPLP HHHHHHHHCCCCCCC	25.78	26657352
66	Phosphorylation	FREVVSFSPDPLPVR HHHHHHCCCCCCCCE	22.38	30266825
87	Ubiquitination	TKPISFYLSSLEELL CCCEEEECCCHHHHH	2.36	21890473
190	Phosphorylation	HGVCVLGTFITEWNE CCEEEEEEEEEEECC	14.01	-
193	Phosphorylation	CVLGTFITEWNEGGR EEEEEEEEEECCCCC	30.66	-
195	Ubiquitination	LGTFITEWNEGGRLC EEEEEEEECCCCCCC	10.26	21890473
251	Ubiquitination	AVGNMPPFLRYLTTQ HHCCCCHHHHHHHHH	5.10	21890473
341	Methylation	RGNVVGGRFDTDKSL CCCCCCCCCCCHHHH	21.97	-
344	Phosphorylation	VVGGRFDTDKSLELI CCCCCCCCHHHHHHH	42.49	-
352	Methylation	DKSLELIRKHGFSVA HHHHHHHHHCCCEEE	37.23	-
373	Ubiquitination	VYECLEKKDFFQNQD HHHHHHHCCHHCCCH	50.85	29967540
381	Ubiquitination	DFFQNQDKFWGRLER CHHCCCHHHHHHHHH	33.00	22817900
381 (in isoform 1)	Ubiquitination	-	33.00	21890473
397	O-linked_Glycosylation	LPTHSICSLPFVTSF CCCCCCCCCHHHHHH	37.09	29351928
673	Phosphorylation	WGGMSDDSPGRELPR CCCCCCCCCCCCCCC	33.96	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENASE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENASE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENASE_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ENASE_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.
PubMed: 19690332