EMIL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMIL1_MOUSE
• UniProt AC: Q99K41
• Protein Name: EMILIN-1
• Gene Name: Emilin1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1017
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Found mainly at the interface between amorphous elastin and microfibrils.
• Protein Description: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (By similarity). May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue..
• Protein Sequence: MAPRALWSCYLCCLLTIATEAASYPPRGYSLYTGGTGALSPGGPQAQNSPRPASRHRNWCAYVVTRTVSCVLEDGVETIVKPDYQPCGWGQPHCSRSIMYRSFLRPRYRVAYKTVTDMEWRCCQGYGGDDCGEGPASVLGPAPSTPLPRPRPVRPNLSGSSAGSHLSGLGGEGPVESEKVQQLERQVKSLTKELQGLRGVLQGMNGRLAEDVQRAVDTVFNGRQQPADAAARPGVHETLSEIQQQLQLLDNRVSTHDQELGHLNNHHNGGPGGGGRASGPVPVPSGPSEELLRQLERQLQESCSVCLTGLDGFRQQQQEDRERLRTLEKLMSSMEERQQQLVGPAMARRPPQECCPPELGRRVSELERRLDVVTGSLTVLSGRRGSELGGAAGQGGHPPGYTSLASRLSRLEDRFNSTLGPSEEQEKNWPGGPGRLGHWLPAAPGRLEKLEGLLANVSRELGGRMDLLEEQVAGAVRTCGQICSGAPGEQDSRVNEILSALERRVLDSEGRLQLVGSGLHEAEAAGEAQQAVLEGLQGLLSRLRERMDAQEETAAEILLRLNLTAAQLSQLEGLLQARGDEGCGACGGVQEELGRLRDGVERCSCPLLPPRGPGAGPGVGGPSRGPLDGFSVFGGSSGSALQALQGELSEVILTFSSLNDSLHELQTTVEGQGADLADLGATKDSIISEINRLQQEATEHVTESEERFRGLEEGQAQAGQCPSLEGRLGRLEGVCERLDTVAGGLQGLREGLSRHVAGLWAAVRESNSTSLTQAALLEKLLGGQAGLGRRLGALNNSLLLLEDRLQQLSLKDFTGPSGKAGPPGPPGLQGPSGPAGPPGPPGKDGQQGAIGPPGPQGEQGAEGAPAAPVPRVAFSAALSLPRSEPGTVPFDRVLLNDGGYYDPETGVFTAPLAGRYLLSAVLTGHRHEKVEAVLSRSNLGVARIDSGGYEPEGLENKPVAESQPSPGALGVFSLILPLQVGDTVCIDLVMGQLAHSEEPLTIFSGALLYEDTELEQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	Phosphorylation	GQPHCSRSIMYRSFL CCCCCCHHHHHHHHH	8.73	30635358
102	Phosphorylation	SRSIMYRSFLRPRYR CHHHHHHHHHCCCEE	15.90	30635358
156	N-linked_Glycosylation	RPRPVRPNLSGSSAG CCCCCCCCCCCCCCC	35.95	-
386	Phosphorylation	VLSGRRGSELGGAAG EEECCCCCCCCCCCC	28.03	25266776
416	N-linked_Glycosylation	SRLEDRFNSTLGPSE HHHHHHHHCCCCCCH	34.67	-
422	Phosphorylation	FNSTLGPSEEQEKNW HHCCCCCCHHHHHCC	52.55	22942356
456	N-linked_Glycosylation	KLEGLLANVSRELGG HHHHHHHHHHHHHCC	32.06	-
562	N-linked_Glycosylation	AEILLRLNLTAAQLS HHHHHHHHCCHHHHH	28.98	-
659	N-linked_Glycosylation	ILTFSSLNDSLHELQ HHHHHHHCHHHHHHH	38.48	-
704	Phosphorylation	ATEHVTESEERFRGL HHHCCCHHHHHHCCH	35.08	26824392
767	N-linked_Glycosylation	WAAVRESNSTSLTQA HHHHHHCCCCCHHHH	44.55	-
795	N-linked_Glycosylation	GRRLGALNNSLLLLE HHHHHHHHHHHHHHH	35.19	-
875	Phosphorylation	PVPRVAFSAALSLPR CCCCEEEEHHHCCCC	11.68	27180971
879	Phosphorylation	VAFSAALSLPRSEPG EEEEHHHCCCCCCCC	31.44	27180971

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMIL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMIL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMIL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EMIL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.