EMAL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMAL6_HUMAN
• UniProt AC: Q6ZMW3
• Protein Name: Echinoderm microtubule-associated protein-like 6
• Gene Name: EML6
• Organism: Homo sapiens (Human).
• Sequence Length: 1958
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic..
• Protein Sequence: MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGIFSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSNGMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVKAHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEGTKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	SYNVQTVSLLKDVHT CCCCCCHHHHCCHHH	31.22	24719451
178	Phosphorylation	VKHIKFWTLCGNALT CCEEEEEECCCCHHH	18.46	23403867
185	Phosphorylation	TLCGNALTAKRGIFG ECCCCHHHHHCCCCC	27.94	-
242	Phosphorylation	AHSAGIFSMYACEEG CHHCCCEEEEEECCC	14.68	22210691
244	Phosphorylation	SAGIFSMYACEEGFA HCCCEEEEEECCCCC	13.60	22210691
252	Phosphorylation	ACEEGFATGGRDGCI EECCCCCCCCCCCEE	37.60	22210691
342	Phosphorylation	PKKPLAVTGSDDRSV CCCCEEECCCCCCCC	25.92	23909892
344	Phosphorylation	KPLAVTGSDDRSVRL CCEEECCCCCCCCHH	27.29	23909892
348	Phosphorylation	VTGSDDRSVRLWSLA ECCCCCCCCHHHHHH	20.70	23909892
379	Phosphorylation	VAFSPDGSQLALGMK EEECCCCCEEEEEEC	29.42	-
389	Phosphorylation	ALGMKDGSFIVLRVR EEEECCCCEEEEEEE	23.18	-
427	Phosphorylation	GSYLAVGSNDGPVDV CCEEEEECCCCCCCH	25.75	-
559	Phosphorylation	RGAKFRKYVGHSAHV CCCCHHHHCCCCCEE	13.86	29083192
563	Phosphorylation	FRKYVGHSAHVTNVR HHHHCCCCCEEEEEE	17.72	29083192
567	Phosphorylation	VGHSAHVTNVRWSHD CCCCCEEEEEEECEE	20.37	-
765	Phosphorylation	TQTLKCLSLLKGQHQ HHHHHHHHHHCCCCC	40.92	24719451
811	Phosphorylation	KKGEKIATTRGHKDK CCCCEEEECCCCCCE	22.09	29083192
812	Phosphorylation	KGEKIATTRGHKDKI CCCEEEECCCCCCEE	26.15	24719451
834	Phosphorylation	HHVDKLVTVGIKHIK HHHHHEEEECCEEEE	24.37	24719451
865	Phosphorylation	GSVGKLETMMCVSYG CCCCCEEEEEEEECC	22.20	30206219
870	Phosphorylation	LETMMCVSYGRMEDL EEEEEEEECCCHHHH	19.55	22210691
871	Phosphorylation	ETMMCVSYGRMEDLV EEEEEEECCCHHHHC	6.59	22210691
939	Phosphorylation	FERCLKTYAIKRSAL HHHHHHHHHHHHHHC	12.54	30576142
948	Phosphorylation	IKRSALSTSSKGLLL HHHHHCCCCCCCEEC	37.56	22210691
949	Phosphorylation	KRSALSTSSKGLLLE HHHHCCCCCCCEECC	27.03	22210691
950	Phosphorylation	RSALSTSSKGLLLED HHHCCCCCCCEECCC	30.72	30576142
1089	Acetylation	KEMISDIKFSKDTGK HHHHHEEEEECCCCC	48.88	11791469
1091	O-linked_Glycosylation	MISDIKFSKDTGKYL HHHEEEEECCCCCEE	25.31	30379171
1096	Acetylation	KFSKDTGKYLAVASH EEECCCCCEEEEEEC	38.90	11791479
1125	Phosphorylation	VGICKGASSYITHID CCCCCCCCCEEEEEE	32.13	20873877
1126	Phosphorylation	GICKGASSYITHIDW CCCCCCCCEEEEEEE	21.74	20873877
1127	Phosphorylation	ICKGASSYITHIDWD CCCCCCCEEEEEEEC	13.82	20873877
1129	Phosphorylation	KGASSYITHIDWDSR CCCCCEEEEEEECCC	12.44	20873877
1135	Phosphorylation	ITHIDWDSRGKLLQV EEEEEECCCCCEEEE	38.38	20873877
1234	Phosphorylation	QHARFKKYVGHSAHV CHHHHHHHHCCCCEE	16.56	29083192
1238	Phosphorylation	FKKYVGHSAHVTNVR HHHHHCCCCEEEEEE	17.72	29083192
1242	Phosphorylation	VGHSAHVTNVRWLHN HCCCCEEEEEEEEEC	20.37	-
1281	Phosphorylation	QESKLVDSEESDTDV CCCCCCCCHHCCCCC	35.47	27732954
1284	Phosphorylation	KLVDSEESDTDVEED CCCCCHHCCCCCCCC	41.58	27732954
1286	Phosphorylation	VDSEESDTDVEEDGG CCCHHCCCCCCCCCC	51.75	27732954
1294	Phosphorylation	DVEEDGGYDSDVARE CCCCCCCCCHHHHHH	20.15	27732954
1296	Phosphorylation	EEDGGYDSDVAREKA CCCCCCCHHHHHHHH	26.04	27732954
1306	Phosphorylation	AREKAIDYTTKIYAV HHHHHHHCCCEEEEE	15.36	18691976
1307	Phosphorylation	REKAIDYTTKIYAVS HHHHHHCCCEEEEEE	20.19	18691976
1308	Phosphorylation	EKAIDYTTKIYAVSI HHHHHCCCEEEEEEH	14.82	24719451
1311	Phosphorylation	IDYTTKIYAVSIREM HHCCCEEEEEEHHHC	11.51	26356563
1355	Ubiquitination	LQKNNITKKKKLVEE HHHCCCCHHHHHHHH	59.82	30230243
1524	Phosphorylation	DSDTQFVSVGVKHMK CCCCCEEEEEECCHH	17.91	28258704
1534	Phosphorylation	VKHMKFWTLAGSALL ECCHHHHHHHHHHHH	15.17	22210691
1538	Phosphorylation	KFWTLAGSALLYKKG HHHHHHHHHHHHHCC	15.33	22210691
1542	Phosphorylation	LAGSALLYKKGVIGS HHHHHHHHHCCCCCH	16.11	-
1549	Phosphorylation	YKKGVIGSLGAAKMQ HHCCCCCHHHHHHHH	16.71	-
1557	Phosphorylation	LGAAKMQTMLSVAFG HHHHHHHHHHHHHHC	19.31	23879269
1560	Phosphorylation	AKMQTMLSVAFGANN HHHHHHHHHHHCCCC	10.69	23879269
1595	Phosphorylation	RLVAKAHTGPVFTMY HHHHHHCCCCEEEEE	48.30	21712546
1600	Phosphorylation	AHTGPVFTMYTTLRD HCCCCEEEEEEEECC	14.98	21712546
1602	Phosphorylation	TGPVFTMYTTLRDGL CCCEEEEEEEECCCE	8.10	21712546
1663	Phosphorylation	KGKILVGTKDGEIIE CCEEEEECCCCCEEE	20.62	-
1759	Phosphorylation	FVILLVNSLKVWGKK EEEEEEECHHHHCCC	23.30	-
1816	Phosphorylation	GYCKDIPSFVIQMDF EEECCCCCEEEEEEE	32.26	-
1824	Phosphorylation	FVIQMDFSADGKYIQ EEEEEEECCCCCEEE	22.61	-
1829	Phosphorylation	DFSADGKYIQVSTGA EECCCCCEEEEECCC	11.34	-
1914	Phosphorylation	KLFDFPCTEKFAKHK EECCCCCCHHHHHCC	42.31	25850435
1923	Phosphorylation	KFAKHKRYFGHSAHV HHHHCCHHCCCCCEE	20.79	29759185
1941	Phosphorylation	RFSYDDKYVVSTGGD EEEECCCEEEECCCC	17.06	29209046
1944	Phosphorylation	YDDKYVVSTGGDDCS ECCCEEEECCCCCCE	15.99	29209046
1945	Phosphorylation	DDKYVVSTGGDDCSV CCCEEEECCCCCCEE	33.31	29209046
1951	Phosphorylation	STGGDDCSVFVWRCL ECCCCCCEEEEEEEC	26.11	29209046

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMAL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMAL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMAL6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EMAL6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.