ELYS_DROME - dbPTM
ELYS_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ELYS_DROME
UniProt AC Q9VWE6
Protein Name Protein ELYS homolog
Gene Name CG14215
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 2111
Subcellular Localization
Protein Description
Protein Sequence MEWHEVELDGSRTIAFPERIVPGFGREPSAHLDAAEYLGGIIRDGQWGWVTWRYGSDATLLVCSMSTGDYLSWHCFWSESDDLGPRKSIRCVEELFPGEHERPAMLAICLESWNSGDQRPIDCPLSTQVLIYAIRNSQVLRRFDLHGITCSALTFLDKRIYGLTRLRRFKGCLAVATEEGTVLLVDLNSDSLQASTQRRSLCSPSSKDEPSDGNLYFVSSEESKRQLSSKLTHCRSKGAHLAVRMDVASIGISCLMGISMAPGYAAGLEDGRILIYDLINFDVTTDLNSPVKRKGVNRAVKRMCLIMPPDDPKPCFYICALYQNIDVLQMMLHSVCYRGSYRDRETHTIRFKDYRSRTVRNRQILDGGICSVIGCATASTFSFAGDNGTLLIVISWHSSADKKNKLVLFDINQWYKDEMPTSVHKNEVPNYMSGYILSGLQTGLALDLRSTTILHFVSLQRYDEHFYPNSLTFDCSLLTPTGKRYYAQDGVQHRFLNALRCDRATLFLRPQIYHEDIVRLRLLPQFCELNPNATFSKIAMYELILSVALEHNCGALLNDCARSWMDGSFLCNMIDNTQLSLSTLTNWILKRAGQIKTRCSELCHGIFDYGGYPLDQRERREFQVLSGQLRELVRLQSYIVEQGRRRLTSSILDDCRANERALKTVLEYQRVLLWFIDHGLLPEGQHMDNLVPGEQAFVRLQHEYSEKRAQGKILYIDSLGKRASFPEPYPPDSLHAYIHLMLSPDIELCHKHALILYLLMDLNQQLVGRFQIAFQLDKDLATSLRCFWYLDHGDYERGVEELYKEPAPAKNLKSWQMRLLIDKLLAEGAVKAAKKVVSRPPGPLSSALHMKVLLANENITEAFQIARLDDDEDGQPLLERFFRHCIEIRRFKVLAELYLREPEERLLYSLLRQCRSRQTDCVQLIMLLQKSKFIEAVSFMDEVAAERERDESSNTILPAYSATMGPVTQNIAGTYLRIRDTLEPYQKTGPLEPFSCQLVKQNASGQLGGIFQSSAVSAHWATQCESPPKMTPVSIQSKIGYTNVPFLRHAQYGHSELPLPRRIVKPVPHQVVEKRQRELEDQRTNLQDQRQLGTERPNKRPCLMVERMVEDVKDYVRSIREKSSNQMEQEEVKQNEATNLLQPPNFLQARQSTTIRQSSSSPQPIPPILKGSGAVDAVKRAPPVATFTALAGPKRFRFVPPIPLRTDKSDKSTEMGSEGAAEGEEETDEIIVEIESRSEPRSACSYESDEEDEFLSPLVSANVSLVDPVPSRNSPHYFAPPAGPQPRNSLLHGGNGSGSKIGTATGSESSSGFGSFSTVQPAQTSSHSQFVPTVCSSKMGETQSQVFSSGSCGIKISERTTICGEMESTDLGAELTAAPSAQWSLPSARPAIQGHHQMMDTTLGMSTYDVASLEQQDTQDVENEEELKLGDTKSLEEQQNPQDEQKPEQEQDQDEDQAQEPLATGGQLAFLSNSEGTAQEPLSSPIYSLSSEDSNVSSAGIRNPMLPTLHTDDPMYSIVVESPGSITTSRSVTHTPTSFLPSDTNVSQTSSPQAPHGEDGDGTPISLYRANSLETVDDLDTTKGSLEEEEEYDDDDCVIALDGTEVRGYVARPQQSAASSSAELFAFKDECQEEAAGVPSPFLSLGATVNSDSDVADTIVLDSDEETAKEKDTQPEQRKDWPMEEETPSNESVATVEFSEQKQPRADMDIGMEVDAVPDVLEVLEVPEMEPLPVLSDVDIEMAVDEVPNVLEVLEVPELEPLPAGQATQSSGLGEIPEEDVDAEAEEQVVVKVEHVADEQPKEGDKTESKEASEEETQHNPEPLLPEEEDSRHSLKLIFSGDEDEEEQDVPTRAIHTLRPRRSFTEHQDSPRTLRPRRVSQEHRDSPTPVAGRTMSLRSTDAPTLSPASNPPVSTPKRRGLQHKYLLEVIDEHSPSDLSLPRTRSRTRLSVDSEATSSRPGTPTMTKARGKRATSQAPPTASPSVRRSLRGHSEPPAALSAQLVRKPKTARAGVRSRKTSSGVQSPVAVSPTPIDAPIDVPDSTAPEEEQPRLRRTARRRISELSDQSANGTGDLRSEASSSRTGSKSNSAASTQNRELRPRLRRTSKSEH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
200PhosphorylationQASTQRRSLCSPSSK
CHHHHCCCCCCCCCC		35.6022817900
203PhosphorylationTQRRSLCSPSSKDEP
HHCCCCCCCCCCCCC		32.8622817900
846PhosphorylationRPPGPLSSALHMKVL
CCCCCHHHHHHHHHH		42.4022817900
916PhosphorylationSLLRQCRSRQTDCVQ
HHHHHHHHCCCHHHH		36.0422817900
1074AcetylationVPHQVVEKRQRELED
CCHHHHHHHHHHHHH		42.0721791702
1123PhosphorylationVRSIREKSSNQMEQE
HHHHHHHCCHHHHHH		29.7527794539
1124PhosphorylationRSIREKSSNQMEQEE
HHHHHHCCHHHHHHH		41.9929892262
1158PhosphorylationQSTTIRQSSSSPQPI
CCCCCCCCCCCCCCC		23.4919429919
1159PhosphorylationSTTIRQSSSSPQPIP
CCCCCCCCCCCCCCC		26.8819429919
1160PhosphorylationTTIRQSSSSPQPIPP
CCCCCCCCCCCCCCC		51.8119429919
1161PhosphorylationTIRQSSSSPQPIPPI
CCCCCCCCCCCCCCC		29.5119429919
1274PhosphorylationDPVPSRNSPHYFAPP
CCCCCCCCCCCCCCC		16.3719429919
1277PhosphorylationPSRNSPHYFAPPAGP
CCCCCCCCCCCCCCC		12.5719429919
1522PhosphorylationMYSIVVESPGSITTS
CEEEEEECCCCEEEC		23.9722817900
1525PhosphorylationIVVESPGSITTSRSV
EEEECCCCEEECCCC		21.8322817900
1551PhosphorylationTNVSQTSSPQAPHGE
CCCCCCCCCCCCCCC		25.1522668510
1572PhosphorylationISLYRANSLETVDDL
EEEEECCCCCCCCCC		26.9719429919
1689PhosphorylationPMEEETPSNESVATV
CCCCCCCCCCCCEEE		61.7322817900
1692PhosphorylationEETPSNESVATVEFS
CCCCCCCCCEEEEEC		22.6922817900
1695PhosphorylationPSNESVATVEFSEQK
CCCCCCEEEEECCCC		20.5722817900
1831PhosphorylationLLPEEEDSRHSLKLI
CCCCCCCCCCEEEEE		34.8619429919
1834PhosphorylationEEEDSRHSLKLIFSG
CCCCCCCEEEEEECC		26.5319429919
1840PhosphorylationHSLKLIFSGDEDEEE
CEEEEEECCCCCHHH		38.0421082442
1863PhosphorylationHTLRPRRSFTEHQDS
HHCCCCCCCCCCCCC		37.4919429919
1865PhosphorylationLRPRRSFTEHQDSPR
CCCCCCCCCCCCCCC		33.5319429919
1870PhosphorylationSFTEHQDSPRTLRPR
CCCCCCCCCCCCCCC		15.0922817900
1880PhosphorylationTLRPRRVSQEHRDSP
CCCCCCCCHHCCCCC		28.2125749252
1886PhosphorylationVSQEHRDSPTPVAGR
CCHHCCCCCCCCCCC		30.5425749252
1888PhosphorylationQEHRDSPTPVAGRTM
HHCCCCCCCCCCCCE		34.0525749252
1906PhosphorylationSTDAPTLSPASNPPV
CCCCCCCCCCCCCCC		22.3930478224
1909PhosphorylationAPTLSPASNPPVSTP
CCCCCCCCCCCCCCC		53.9428490779
1914PhosphorylationPASNPPVSTPKRRGL
CCCCCCCCCCCCCCC		44.7828490779
1915PhosphorylationASNPPVSTPKRRGLQ
CCCCCCCCCCCCCCC		32.8222817900
1934PhosphorylationLEVIDEHSPSDLSLP
HHHHHCCCCCCCCCC		24.8528490779
1939PhosphorylationEHSPSDLSLPRTRSR
CCCCCCCCCCCCCCC		41.1218327897
1950PhosphorylationTRSRTRLSVDSEATS
CCCCCEEEECCCCCC		22.1622817900
1953PhosphorylationRTRLSVDSEATSSRP
CCEEEECCCCCCCCC		27.2922817900
1956PhosphorylationLSVDSEATSSRPGTP
EEECCCCCCCCCCCC		24.1522817900
1957PhosphorylationSVDSEATSSRPGTPT
EECCCCCCCCCCCCC		31.2522817900
1958PhosphorylationVDSEATSSRPGTPTM
ECCCCCCCCCCCCCC		37.8322817900
1962PhosphorylationATSSRPGTPTMTKAR
CCCCCCCCCCCCCCC		20.4725749252
1974PhosphorylationKARGKRATSQAPPTA
CCCCCCCCCCCCCCC		25.9625749252
1975PhosphorylationARGKRATSQAPPTAS
CCCCCCCCCCCCCCC		24.3022668510
1980PhosphorylationATSQAPPTASPSVRR
CCCCCCCCCCHHHHH		38.4129892262
1982PhosphorylationSQAPPTASPSVRRSL
CCCCCCCCHHHHHHH		21.8622817900
1984PhosphorylationAPPTASPSVRRSLRG
CCCCCCHHHHHHHCC		26.2625749252
1993PhosphorylationRRSLRGHSEPPAALS
HHHHCCCCCCCHHHH		55.4025749252
2020PhosphorylationGVRSRKTSSGVQSPV
CCCCCCCCCCCCCCE		28.2922817900
2025PhosphorylationKTSSGVQSPVAVSPT
CCCCCCCCCEEECCC		20.9522817900
2030PhosphorylationVQSPVAVSPTPIDAP
CCCCEEECCCCCCCC		17.2030478224
2032PhosphorylationSPVAVSPTPIDAPID
CCEEECCCCCCCCCC		25.9330478224
2062PhosphorylationRTARRRISELSDQSA
HHHHHHHHHHHHCCC		30.5825749252
2065PhosphorylationRRRISELSDQSANGT
HHHHHHHHHCCCCCC		29.5625749252
2068PhosphorylationISELSDQSANGTGDL
HHHHHHCCCCCCCCC		28.7922817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ELYS_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ELYS_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ELYS_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ELYS_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1840, AND MASSSPECTROMETRY.
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-1274; SER-1522;SER-1525; SER-1551; SER-1692; THR-1695; SER-1831; SER-1834; SER-1863;SER-1870; SER-1880; SER-1886; THR-1888; SER-1934; SER-1939; SER-1950;SER-1953; THR-1956; SER-1957; SER-1958; THR-1962; SER-1975; SER-1982;SER-2025; SER-2062; SER-2065 AND SER-2068, AND MASS SPECTROMETRY.

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