dbPTM

ELP5_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ELP5_RAT
UniProt AC	Q6IUP3
Protein Name	Elongator complex protein 5
Gene Name	Elp5
Organism	Rattus norvegicus (Rat).
Sequence Length	318
Subcellular Localization	Nucleus. Cytoplasm.
Protein Description	Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. May be involved in TP53-mediated transcriptional regulation (By similarity)..
Protein Sequence	MPRLLSGDDIRRRPEASEMLDSLLATGGLVLLRDSVEWEGRGLLKALIKKSALRGEQVHVLGCEVSEEEFREGLGSDVNSRLVYHDLFRDPLNWSQPGEAAPEGPLKALRSMCRRTDRGSVTIALDSLSWLLCHIPCVTLCQALHALSQRNVDPGDNPLIEQVRVLGLLHEELHGPGPVGAVSSLAHTEVTLSGKMDQTSASILCRRPQQRATYQTWWFSILPDFSLDLHEGLPLHSELHRDPHTTQVDPASHLTFNLHLSKKEREAKDSLTLPFQFSSEKQQALLHPVPGQTTGRIFYEPDAFDDVDQEDPDDDLDI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
270	Phosphorylation	KEREAKDSLTLPFQF HHHHHHHCEECCCCC	-
278	Phosphorylation	LTLPFQFSSEKQQAL EECCCCCCCHHHHHH	27097102
279	Phosphorylation	TLPFQFSSEKQQALL ECCCCCCCHHHHHHH	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ELP5_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ELP5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ELP5_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ELP5_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ELP5_RAT

Related Literatures of Post-Translational Modification