ELOA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELOA3_HUMAN
• UniProt AC: Q8NG57
• Protein Name: Elongin-A3
• Gene Name: ELOA3 {ECO:0000312|HGNC:HGNC:24617}
• Organism: Homo sapiens (Human).
• Sequence Length: 546
• Subcellular Localization: Nucleus .
• Protein Description: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)..
• Protein Sequence: MAAGSTTLRAVGKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTGPDPQDPEESASRQRFGEALQEREKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSPSREPRAERKRPRMAPADSGPHRDPPTRTAPLPMPEGPEPAVPGEQPGRGHAHAAQGGPLLGQGCQGQPQGEAVGSHSKGHKSSRGASAQKSPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDPSEAWMQANYDLLSAFEAMTSQANPEALSAPALQEEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCLRVPRNNPDALGDVEGVPYSVLEPVLEGWTPDQLYRTEKDNAALARETDELWRIHCLQDFKEEKPQEHESWRELYLRLRDAREQRLRVVTTKIRSARENKPSGRQTKMICFNSVAKTPYDASRRQEKSAGAADPGNGEMEPAPKPAGSSQAPSGLGDGDGGSVSGGGSSNRHAAPADKTRKQAAKKVAPLMAKAIRDYKGRFSRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAAGSTTLRAVG ---CCCCCHHHHHHH	17.31	29083192
6	Phosphorylation	--MAAGSTTLRAVGK --CCCCCHHHHHHHH	29.00	29083192
7	Phosphorylation	-MAAGSTTLRAVGKL -CCCCCHHHHHHHHH	18.88	29083192
21	Acetylation	LQVRLATKTEPKKLE HHHEECCCCCHHHHH	45.33	-
26	Methylation	ATKTEPKKLEKYLQK CCCCCHHHHHHHHHH	73.01	-
26	"N6,N6-dimethyllysine"	ATKTEPKKLEKYLQK CCCCCHHHHHHHHHH	73.01	-
238	Phosphorylation	RGASAQKSPPVQESQ CCCCCCCCCCCCCHH	23.50	-
416	Phosphorylation	HESWRELYLRLRDAR CHHHHHHHHHHHHHH	5.75	22817900
432	Phosphorylation	QRLRVVTTKIRSARE HHHHHHHHHHHHHHH	16.92	28555341
447	Phosphorylation	NKPSGRQTKMICFNS CCCCCCCCEEEEEHH	22.63	22817900
469	Phosphorylation	ASRRQEKSAGAADPG HHHHHHHHCCCCCCC	31.05	25954137
489	Phosphorylation	PAPKPAGSSQAPSGL CCCCCCCCCCCCCCC	22.76	25954137
490	Phosphorylation	APKPAGSSQAPSGLG CCCCCCCCCCCCCCC	29.46	25954137
503	Phosphorylation	LGDGDGGSVSGGGSS CCCCCCCCCCCCCCC	20.74	25954137
505	Phosphorylation	DGDGGSVSGGGSSNR CCCCCCCCCCCCCCC	33.16	25954137
509	Phosphorylation	GSVSGGGSSNRHAAP CCCCCCCCCCCCCCC	27.93	22210691
510	Phosphorylation	SVSGGGSSNRHAAPA CCCCCCCCCCCCCCC	40.95	25954137
520	Phosphorylation	HAAPADKTRKQAAKK CCCCCHHHHHHHHHH	43.58	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELOA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELOA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELOA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOB_HUMAN	TCEB2	physical	11994304
ELOC_HUMAN	TCEB1	physical	11994304

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.