ELG1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELG1_SCHPO
• UniProt AC: O43086
• Protein Name: Telomere length regulation protein elg1
• Gene Name: elg1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 920
• Subcellular Localization: Nucleus . Chromosome, telomere .
• Protein Description: Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. An RFC-like complex (elg1-RFC) is formed where elg1 replaces rfc1 in the RFC complex. This complex appears to have a role in DNA replication, replication fork re-start, recombination and repair..
• Protein Sequence: MQIVGYLSADSQSNPDLKSENEAKEEKPIGRRHTMSPVPATSENKYFGKSPLSGSRKPRRSRSLHKERSYMRKFFDMDMEESKDFENDQSLLVTLKVSTSLGQKIENILHPKLSNDTNSTAFPPAKSSGEASDTNILVENINSQETVNSSPLVSELHYSNLADSPSNLRNTVTSMHPFFMSKSVKKNSEIKFVSEERGGTKPERLLDPLWPTPDSQSMLEYAGSIEPSVFWFPKKHLEEAILEETSHLSFKEVLSSTTANMITPLAEKNKTEVLQVTPSKLHTFALESLCFSPAPFIQKVLSRLLPSDPNVEMPMIPQILEKGLWVSKYAPSKTQDCCAFSQCLSKIADWLRSCRLTKPESSSVPPSSSISRSSTIHSCTSSKRNEDSLSESDFEPDIIEEEDDSDEFNPSVSRKKAKLTSSQFSNWMLVTGVTGIGKTSCLYAICRELNFEVVEIHPGMRRSGKELLERIGELTQSHIVDKSRLNNTPDILILLEEVDILFQDDRGFWQAVSTLIEKSKRPVVMTCNETDFLPSAFLQEDHIVQFQSISSALLTDYISSVLYADRCIISRNVVESISYRYGSDLRGILMQLNFWSLVNFPSLPSKDKQDDSHEPFIEATISAFDEGVGVYNPRIQTSEDLLQTYSEEQMGDIGLLFMPNLVNWRKVCVPKSEMEEKEAIMEKLIYSHQYADSLSYVDYRFSSQPTIYETYELMNDSASFEDMSLECRDNCANAFQDNLVGFPTISNPFHANAPPEPHELKLQYHSFCFINNLFSKSSLKAISSNDSIVPKALNNRELQLSALASTIGYKLDPDDVYNILSFLSFANSQVTSYTPPNSIDRPNDILILEVAPFVRCMRRYDRIRLNSYKLLLSSKGRSASHISRRGAASILRSAGYNYGRLQYLEGSDRILSTWFSTTLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	KPIGRRHTMSPVPAT CCCCCCCCCCCCCCC	19.96	24763107
36	Phosphorylation	IGRRHTMSPVPATSE CCCCCCCCCCCCCCC	24.73	25720772
41	Phosphorylation	TMSPVPATSENKYFG CCCCCCCCCCCCCCC	30.42	21712547
42	Phosphorylation	MSPVPATSENKYFGK CCCCCCCCCCCCCCC	41.08	24763107
50	Phosphorylation	ENKYFGKSPLSGSRK CCCCCCCCCCCCCCC	31.30	29996109
271	Phosphorylation	PLAEKNKTEVLQVTP HHHHCCCCEEEEECH	40.49	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELG1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELG1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELG1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFC2_SCHPO	rfc2	physical	16040599
RFC3_SCHPO	rfc3	physical	16040599
RFC4_SCHPO	rfc4	physical	16040599
RFC5_SCHPO	rfc5	physical	16040599

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.