ELFN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELFN1_HUMAN
• UniProt AC: P0C7U0
• Protein Name: Protein ELFN1
• Gene Name: ELFN1
• Organism: Homo sapiens (Human).
• Sequence Length: 828
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cell projection, dendrite. Localizes to excitatory synapses onto somatostatin (Sst)-containing oriens-lacunosum moleculare (O-LM) interneurons..
• Protein Description: Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes..
• Protein Sequence: MAGRGWGALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHRSILSKLQSVCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGTTPLVALPTLATQAEARPLIKVKQLTQNSATITVQLPSPFHRMYTLEHFNNSKASTVSRLTKAQEEIRLTNLFTLTNYTYCVVSTSAGLRHNHTCLTICLPRLPSPPGPVPSPSTATHYIMTILGCLFGMVLVLGAVYYCLRRRRRQEEKHKKAASAAAAGSLKKTIIELKYGPELEAPGLAPLSQGPLLGPEAVTRIPYLPAAGEVEQYKLVESADTPKASKGSYMEVRTGDPPERRDCELGRPGPDSQSSVAEISTIAKEVDKVNQIINNCIDALKSESTSFQGVKSGPVSVAEPPLVLLSEPLAAKHGFLAPGYKDAFGHSLQRHHSVEAAGPPRASTSSSGSVRSPRAFRAEAVGVHKAAAAEAKYIEKGSPAADAILTVTPAAAVLRAEAEKGRQYGEHRHSYPGSHPAEPPAPPGPPPPPPHEGLGRKASILEPLTRPRPRDLAYSQLSPQYHSLSYSSSPEYTCRASQSIWERFRLSRRRHKEEEEFMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQHKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	N-linked_Glycosylation	EAIPQQINSTIVDLR HHCCHHHHHEEEEEC		UniProtKB CARBOHYD
74	Phosphorylation	LNENRIRSVQYASLS CCCHHHCEEEEEEEH		23917254
79	Phosphorylation	IRSVQYASLSRFGNL HCEEEEEEEHHCCCE		27174698
81	Phosphorylation	SVQYASLSRFGNLTY EEEEEEEHHCCCEEE		27174698
85	N-linked_Glycosylation	ASLSRFGNLTYLNLT EEEHHCCCEEEEECC		UniProtKB CARBOHYD
90	N-linked_Glycosylation	FGNLTYLNLTKNEIG CCCEEEEECCCCCEE		UniProtKB CARBOHYD
122	N-linked_Glycosylation	LGYNRLRNLTEGMLR HCHHHHHHHCHHHHH		UniProtKB CARBOHYD
210	N-linked_Glycosylation	RWLAAFTNATQTYDR HHHHHHCCCCHHCCC		UniProtKB CARBOHYD
241	Phosphorylation	QGRRGHRSILSKLQS CCCCCHHHHHHHHHH		24719451
328	Phosphorylation	VKQLTQNSATITVQL EEEECCCCEEEEEEC		-
376	N-linked_Glycosylation	TNLFTLTNYTYCVVS HHCCCCCCEEEEEEE		UniProtKB CARBOHYD
452	Ubiquitination	RQEEKHKKAASAAAA HHHHHHHHHHHHHHH		32142685
461	Phosphorylation	ASAAAAGSLKKTIIE HHHHHHHHHHHHHEE		30266825
463	Ubiquitination	AAAAGSLKKTIIELK HHHHHHHHHHHEEEE		32142685
499	Phosphorylation	EAVTRIPYLPAAGEV CHHHCCCCCCCCCCE		27642862
509	Phosphorylation	AAGEVEQYKLVESAD CCCCEEEEEEEECCC		24173317
514	Phosphorylation	EQYKLVESADTPKAS EEEEEEECCCCCCCC		-
517	Phosphorylation	KLVESADTPKASKGS EEEECCCCCCCCCCC		21815630
524	Phosphorylation	TPKASKGSYMEVRTG CCCCCCCCCEEEECC		-
525	Phosphorylation	PKASKGSYMEVRTGD CCCCCCCCEEEECCC		-
550	Phosphorylation	RPGPDSQSSVAEIST CCCCCCCHHHHHHHH		-
557	Phosphorylation	SSVAEISTIAKEVDK HHHHHHHHHHHHHHH		-
592	O-linked_Glycosylation	GVKSGPVSVAEPPLV CCCCCCCCCCCCCEE		28657654
616	Phosphorylation	HGFLAPGYKDAFGHS CCCCCCCHHHHCCHH		-
623	Phosphorylation	YKDAFGHSLQRHHSV HHHHCCHHHHHCCCC		30266825
629	Phosphorylation	HSLQRHHSVEAAGPP HHHHHCCCCCCCCCC		28258704
639	Phosphorylation	AAGPPRASTSSSGSV CCCCCCCCCCCCCCC		-
640	Phosphorylation	AGPPRASTSSSGSVR CCCCCCCCCCCCCCC		-
645	Phosphorylation	ASTSSSGSVRSPRAF CCCCCCCCCCCCHHC		24275569
648	Phosphorylation	SSSGSVRSPRAFRAE CCCCCCCCCHHCCCH		-
674	Phosphorylation	AKYIEKGSPAADAIL HHHHHCCCCCHHHHE		29523821
706	Phosphorylation	QYGEHRHSYPGSHPA CCCCCCCCCCCCCCC		24275569
707	Phosphorylation	YGEHRHSYPGSHPAE CCCCCCCCCCCCCCC		24275569
710	Phosphorylation	HRHSYPGSHPAEPPA CCCCCCCCCCCCCCC		24275569
735	Phosphorylation	EGLGRKASILEPLTR CCCCCCCCCCCCCCC		30266825
741	Phosphorylation	ASILEPLTRPRPRDL CCCCCCCCCCCCCHH		32142685
750	Phosphorylation	PRPRDLAYSQLSPQY CCCCHHHCCCCCCCC		21945579
751	Phosphorylation	RPRDLAYSQLSPQYH CCCHHHCCCCCCCCC		21945579
754	Phosphorylation	DLAYSQLSPQYHSLS HHHCCCCCCCCCCCC		21945579
757	Phosphorylation	YSQLSPQYHSLSYSS CCCCCCCCCCCCCCC		21945579
759	Phosphorylation	QLSPQYHSLSYSSSP CCCCCCCCCCCCCCC		21945579
761	Phosphorylation	SPQYHSLSYSSSPEY CCCCCCCCCCCCCCC		21945579
762	Phosphorylation	PQYHSLSYSSSPEYT CCCCCCCCCCCCCCE		21945579
763	Phosphorylation	QYHSLSYSSSPEYTC CCCCCCCCCCCCCEE		21945579
764	Phosphorylation	YHSLSYSSSPEYTCR CCCCCCCCCCCCEEC		21945579
818	Phosphorylation	DLHDILDYWKGVSAQ CHHHHHHHHHCCCCC		-
823	Phosphorylation	LDYWKGVSAQHKS-- HHHHHCCCCCCCC--		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELFN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELFN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELFN1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ELFN1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.