dbPTM

ELAV4_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ELAV4_RAT
UniProt AC	O09032
Protein Name	ELAV-like protein 4
Gene Name	Elavl4
Organism	Rattus norvegicus (Rat).
Sequence Length	373
Subcellular Localization
Protein Description	Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity). May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR..
Protein Sequence	MEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGAATDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	SNNRNCPSPMQTGAA CCCCCCCCCCCCCCC	34.89	27097102
30	Phosphorylation	NCPSPMQTGAATDDS CCCCCCCCCCCCCCC	23.65	27097102
38	Phosphorylation	GAATDDSKTNLIVNY CCCCCCCCCCEEEEC	48.72	-
95	Ubiquitination	IDPKDAEKAINTLNG CCHHHHHHHHHHHHC	57.18	-
209	Ubiquitination	FANNPSQKSSQALLS ECCCCCHHHHHHHHH	57.31	-
219	Phosphorylation	QALLSQLYQSPNRRY HHHHHHHHCCCCCCC	10.17	25403869
221	Phosphorylation	LLSQLYQSPNRRYPG HHHHHHCCCCCCCCC	15.58	27097102
233	Phosphorylation	YPGPLHHQAQRFRLD CCCCCCHHHHHHHHH	28.57	22673903
236	Methylation	PLHHQAQRFRLDNLL CCCHHHHHHHHHHHH	22.97	16508003
248	Methylation	NLLNMAYGVKRLMSG HHHHHHHHHHHHHCC	14.66	16508003

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ELAV4_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
248	R	Methylation		16508003
Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ELAV4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ELAV4_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ELAV4_RAT

Related Literatures of Post-Translational Modification

Methylation
Reference	PubMed
"CARM1 regulates proliferation of PC12 cells by methylating HuD."; Fujiwara T., Mori Y., Chu D.L., Koyama Y., Miyata S., Tanaka H.,Yachi K., Kubo T., Yoshikawa H., Tohyama M.; Mol. Cell. Biol. 26:2273-2285(2006). Cited for: FUNCTION, AND METHYLATION AT ARG-236.	16508003 [Abstract]