dbPTM

EIF3J_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EIF3J_DROME
UniProt AC	Q7K550
Protein Name	Eukaryotic translation initiation factor 3 subunit J {ECO:0000255\|HAMAP-Rule:MF_03009}
Gene Name	eIF3j {ECO:0000255\|HAMAP-Rule:MF_03009}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	236
Subcellular Localization	Cytoplasm .
Protein Description	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation..
Protein Sequence	MADDWESAADSEVVIRPTAAASVNKWEGEDEDEDIKDSWEDEEEKKDEEKPTKTEAPAKPKPNKALKAKLEQQALLEEEAEAKRLANLSPAEKLAEKLRLQKIQEASDLKHAQEAFGVTSTCGGLDAFNPETKEEFKEFGATLSWKVGQFRESEHFPQFVEDLVRSLCVNLSAADIKKVKMNVEILHSEKLKLEKANAKKPAGKGKGKVTLRTENDDIDGYQKYGNDFTEDYDDFM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MADDWESAADSEVV -CCCCHHHHCCCCEE	25.22	19429919
11	Phosphorylation	DWESAADSEVVIRPT CHHHHCCCCEEECCC	27.80	19429919
38	Phosphorylation	EDEDIKDSWEDEEEK CCCCCHHHCCCHHHH	27.62	19429919
89	Phosphorylation	AKRLANLSPAEKLAE HHHHCCCCHHHHHHH	23.13	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EIF3J_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EIF3J_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EIF3J_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CNC_DROME	cnc	physical	14605208

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EIF3J_DROME

Related Literatures of Post-Translational Modification