dbPTM

EI2BA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EI2BA_MOUSE
UniProt AC	Q99LC8
Protein Name	Translation initiation factor eIF-2B subunit alpha
Gene Name	Eif2b1
Organism	Mus musculus (Mouse).
Sequence Length	305
Subcellular Localization
Protein Description	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
Protein Sequence	MEDGELIEYFKSQMKGDPKMASAVAAIQTLLEFLKRDKGETLQGLRANLTYAIKTLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLRRISLSRNKIANLCHTFIKDGARILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLSGKKMAKALSHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQEDVPDKFKYKADTLKSVQTGQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Acetylation	QTLLEFLKRDKGETL HHHHHHHHHCCCCCH	64.96	-
50	Phosphorylation	QGLRANLTYAIKTLC HHHHHHHHHHHHHHH	15.66	27180971
51	Phosphorylation	GLRANLTYAIKTLCG HHHHHHHHHHHHHHC	14.97	27180971
105	Phosphorylation	ELFLRRISLSRNKIA HHHHHHHHCCCCHHH	20.62	19854140
107	Phosphorylation	FLRRISLSRNKIANL HHHHHHCCCCHHHHH	27.32	22982522
120	Acetylation	NLCHTFIKDGARILT HHHHHHHHCHHHHHH	46.01	22826441
151	Phosphorylation	AKKRFSVYITESQPD HHCCEEEEEECCCCC	10.83	25177544
153	Phosphorylation	KRFSVYITESQPDLS CCEEEEEECCCCCCC	16.34	25177544
218	Glutathionylation	GTNQMAVCAKAQNKP CCCCHHHHHHCCCCC	2.03	24333276
258	Ubiquitination	KYKADTLKSVQTGQD CCCHHHHHHCCCCCC	51.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EI2BA_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EI2BA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EI2BA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of EI2BA_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EI2BA_MOUSE

Related Literatures of Post-Translational Modification