EFR_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFR_ARATH
• UniProt AC: C0LGT6
• Protein Name: LRR receptor-like serine/threonine-protein kinase EFR
• Gene Name: EFR
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1031
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein.
• Protein Description: Constitutes the pattern-recognition receptor (PPR) that determines the specific perception of elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Reduces transformation by Rhizobium radiobacter probably by inducing plant defense during the interaction. Binding to the effector AvrPto1 from P.syringae blocks the downstream plant immune response while interaction with hopD2 decreases the phosphorylation level of EFR upon elf18 treatment. Specific endoplasmic reticulum quality control components (ERD2B, CRT3, UGGT and STT3A) are required for the biogenesis of EFR..
• Protein Sequence: MKLSFSLVFNALTLLLQVCIFAQARFSNETDMQALLEFKSQVSENNKREVLASWNHSSPFCNWIGVTCGRRRERVISLNLGGFKLTGVISPSIGNLSFLRLLNLADNSFGSTIPQKVGRLFRLQYLNMSYNLLEGRIPSSLSNCSRLSTVDLSSNHLGHGVPSELGSLSKLAILDLSKNNLTGNFPASLGNLTSLQKLDFAYNQMRGEIPDEVARLTQMVFFQIALNSFSGGFPPALYNISSLESLSLADNSFSGNLRADFGYLLPNLRRLLLGTNQFTGAIPKTLANISSLERFDISSNYLSGSIPLSFGKLRNLWWLGIRNNSLGNNSSSGLEFIGAVANCTQLEYLDVGYNRLGGELPASIANLSTTLTSLFLGQNLISGTIPHDIGNLVSLQELSLETNMLSGELPVSFGKLLNLQVVDLYSNAISGEIPSYFGNMTRLQKLHLNSNSFHGRIPQSLGRCRYLLDLWMDTNRLNGTIPQEILQIPSLAYIDLSNNFLTGHFPEEVGKLELLVGLGASYNKLSGKMPQAIGGCLSMEFLFMQGNSFDGAIPDISRLVSLKNVDFSNNNLSGRIPRYLASLPSLRNLNLSMNKFEGRVPTTGVFRNATAVSVFGNTNICGGVREMQLKPCIVQASPRKRKPLSVRKKVVSGICIGIASLLLIIIVASLCWFMKRKKKNNASDGNPSDSTTLGMFHEKVSYEELHSATSRFSSTNLIGSGNFGNVFKGLLGPENKLVAVKVLNLLKHGATKSFMAECETFKGIRHRNLVKLITVCSSLDSEGNDFRALVYEFMPKGSLDMWLQLEDLERVNDHSRSLTPAEKLNIAIDVASALEYLHVHCHDPVAHCDIKPSNILLDDDLTAHVSDFGLAQLLYKYDRESFLNQFSSAGVRGTIGYAAPEYGMGGQPSIQGDVYSFGILLLEMFSGKKPTDESFAGDYNLHSYTKSILSGCTSSGGSNAIDEGLRLVLQVGIKCSEEYPRDRMRTDEAVRELISIRSKFFSSKTTITESPRDAPQSSPQEWMLNTDMHTM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	N-linked_Glycosylation	FAQARFSNETDMQAL HHHHHCCCCCCHHHH	54.17	-
55	N-linked_Glycosylation	REVLASWNHSSPFCN HHHHHHCCCCCCCCC	23.75	-
95	N-linked_Glycosylation	VISPSIGNLSFLRLL EECCCCCHHHHHHHH	30.73	-
127	N-linked_Glycosylation	LFRLQYLNMSYNLLE HHHHHHHCCCHHHHC	16.66	-
143	N-linked_Glycosylation	RIPSSLSNCSRLSTV CCCHHHCCCCCCEEE	32.83	-
180	N-linked_Glycosylation	ILDLSKNNLTGNFPA HEECCCCCCCCCCCH	42.59	-
191	N-linked_Glycosylation	NFPASLGNLTSLQKL CCCHHHCCCHHHHHH	45.50	-
239	N-linked_Glycosylation	GFPPALYNISSLESL CCCCHHHCHHHCCCC	28.63	-
288	N-linked_Glycosylation	AIPKTLANISSLERF CCCHHHHCHHHCCCC	37.47	-
301	Phosphorylation	RFDISSNYLSGSIPL CCCCCCCCCCCCCCC	12.28	19880383
303	Phosphorylation	DISSNYLSGSIPLSF CCCCCCCCCCCCCCC	21.82	24894044
323	N-linked_Glycosylation	LWWLGIRNNSLGNNS EEEEEECCCCCCCCC	40.29	-
329	N-linked_Glycosylation	RNNSLGNNSSSGLEF CCCCCCCCCCCHHHH	41.28	-
342	N-linked_Glycosylation	EFIGAVANCTQLEYL HHHHHHCCCCCCCEE	23.83	-
366	N-linked_Glycosylation	ELPASIANLSTTLTS CCCHHHHHHHHHHHH	32.62	-
439	N-linked_Glycosylation	EIPSYFGNMTRLQKL CCCHHCCCCHHHEEE	20.82	-
478	N-linked_Glycosylation	WMDTNRLNGTIPQEI HHCCCCCCCCCCHHH	42.18	-
571	N-linked_Glycosylation	NVDFSNNNLSGRIPR CCCCCCCCCCCCHHH	39.57	-
590	N-linked_Glycosylation	LPSLRNLNLSMNKFE CHHHHCCCCCCCCCC	33.35	-
608	N-linked_Glycosylation	PTTGVFRNATAVSVF CCCCCCCCCEEEEEC	30.13	-
683	Phosphorylation	RKKKNNASDGNPSDS HHHCCCCCCCCCCCC	48.45	25561503
688	Phosphorylation	NASDGNPSDSTTLGM CCCCCCCCCCCCHHH	48.47	25561503
690	Phosphorylation	SDGNPSDSTTLGMFH CCCCCCCCCCHHHHC	27.85	25561503
691	Phosphorylation	DGNPSDSTTLGMFHE CCCCCCCCCHHHHCC	30.91	25561503
692	Phosphorylation	GNPSDSTTLGMFHEK CCCCCCCCHHHHCCC	25.85	25561503
709	Phosphorylation	YEELHSATSRFSSTN HHHHHHHHHCCCCCC	24.37	-
791	Phosphorylation	NDFRALVYEFMPKGS CCHHHHHHHHCCCCC	12.33	-
836	Phosphorylation	DVASALEYLHVHCHD HHHHHHHHHHHHCCC	11.71	24625928
897	Phosphorylation	GVRGTIGYAAPEYGM CCCCCCEEECCCCCC	8.85	21789174
995	Phosphorylation	EAVRELISIRSKFFS HHHHHHHHHHHHHHC	25.27	17317660
1002	Phosphorylation	SIRSKFFSSKTTITE HHHHHHHCCCCCCCC	33.77	19880383
1008	Phosphorylation	FSSKTTITESPRDAP HCCCCCCCCCCCCCC	28.46	25561503
1010	Phosphorylation	SKTTITESPRDAPQS CCCCCCCCCCCCCCC	19.31	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFR_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFR_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFR_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAK1_ARATH	BAK1	physical	21593986
BAK1_ARATH	BAK1	physical	25070640
BAK1_ARATH	BAK1	physical	24130196
RBOHD_ARATH	RBOHD	physical	24630626

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.