EFNA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFNA1_MOUSE
• UniProt AC: P52793
• Protein Name: Ephrin-A1
• Gene Name: Efna1
• Organism: Mus musculus (Mouse).
• Sequence Length: 205
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .; Ephrin-A1, secreted form: Secreted .
• Protein Description: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis..
• Protein Sequence: MEFLWAPLLGLCCSLAAADRHIVFWNSSNPKFREEDYTVHVQLNDYLDIICPHYEDDSVADAAMERYTLYMVEHQEYVACQPQSKDQVRWNCNRPSAKHGPEKLSEKFQRFTPFILGKEFKEGHSYYYISKPIYHQESQCLKLKVTVNGKITHNPQAHVNPQEKRLQADDPEVQVLHSIGYSAAPRLFPLVWAVLLLPLLLLQSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	N-linked_Glycosylation	DRHIVFWNSSNPKFR HCCEEEEECCCCCCC	24.89	-
125	Phosphorylation	KEFKEGHSYYYISKP CHHCCCCCEEEECCC	26.20	-
126	Phosphorylation	EFKEGHSYYYISKPI HHCCCCCEEEECCCE	8.46	-
127	Phosphorylation	FKEGHSYYYISKPIY HCCCCCEEEECCCEE	9.42	-
182	GPI-anchor	VLHSIGYSAAPRLFP HHHHCCCCCHHCHHH	16.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFNA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFNA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFNA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EFNA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.