EFN4_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFN4_CAEEL
• UniProt AC: O44516
• Protein Name: Ephrin-4
• Gene Name: efn-4
• Organism: Caenorhabditis elegans.
• Sequence Length: 348
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. [PubMed: 12679110 In early embryonic development, involved in ventral closure of the epidermis]
• Protein Sequence: MKQFFEFLITTFLLLGLAAADEHIVYWNSTNSLFRNRQPTIEVRMGDVVRFVCPDNEEGRNDGEYLIVYEVTEFAMDDCALESHSREVIRCAPEGTAEKVLRTQQLSGGRREDWKKQKVPPKNVAQLIRQLNPIPNGKEYQPGQTYYYMTTSTGKANGTNHRMYGLCESQNMRLSMKVSASQPHPTRRAPTRRQEDFVTTASAELMGGQEDEDSDNDNAHLLPRDLEGSTNPKFRRPSQLETAGVENQQFMKVVQMAQAGKTGTFENEKEAIAQKSSEKDGWHPVNVQYVADLMNNAYQNADERISYQRDFEIHEENDLAVKSLEYSSSSTSLSTNFAILLAVIYVLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	N-linked_Glycosylation	DEHIVYWNSTNSLFR CCCEEEEECCCHHHC	22.67	-
157	N-linked_Glycosylation	TTSTGKANGTNHRMY ECCCCCCCCCCCEEE	62.40	-
329	GPI-anchor	KSLEYSSSSTSLSTN EEEECCCCCCCHHHH	31.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFN4_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFN4_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFN4_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of EFN4_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.