EFHD2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFHD2_RAT
• UniProt AC: Q4FZY0
• Protein Name: EF-hand domain-containing protein D2
• Gene Name: Efhd2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 239
• Subcellular Localization: Membrane raft. In a mouse immature B-cell line WEHI-231..
• Protein Description: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance..
• Protein Sequence: MATDELASKLSRRLQMEDEGGEATEQPGLNGAAAAAAEAPDETAQALGSADDELSAKLLRRADLNQGIGEPQSPSRRVFNPYTEFKEFSRKQIKDMEKMFKQYDAGKDGFIDLMELKLMMEKLGAPQTHLGLKSMIQEVDEDFDSKLSFREFLLIFRKAAAGELQEDSGLHVLARLSEIDVSTEGVKGAKNFFEAKVQAINVSSRFEEEIKAEQEERKKQAEEVKQRKAAFKELQSTFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATDELASK ------CCHHHHHHH	24.61	-
9	Acetylation	ATDELASKLSRRLQM CHHHHHHHHHHHHHC	44.89	22902405
11	Phosphorylation	DELASKLSRRLQMED HHHHHHHHHHHHCCC	21.06	-
61	Methylation	LSAKLLRRADLNQGI HHHHHHHHCCCCCCC	32.21	-
73	Phosphorylation	QGIGEPQSPSRRVFN CCCCCCCCCCCCCCC	35.24	28689409
75	Phosphorylation	IGEPQSPSRRVFNPY CCCCCCCCCCCCCCC	37.66	27097102
82	Phosphorylation	SRRVFNPYTEFKEFS CCCCCCCCHHHHHHH	21.72	30181290
83	Phosphorylation	RRVFNPYTEFKEFSR CCCCCCCHHHHHHHH	35.88	30181290
91	Acetylation	EFKEFSRKQIKDMEK HHHHHHHHHHHHHHH	56.00	22902405
94	Acetylation	EFSRKQIKDMEKMFK HHHHHHHHHHHHHHH	48.83	22902405
98	Acetylation	KQIKDMEKMFKQYDA HHHHHHHHHHHHHHC	42.89	22902405
101	Acetylation	KDMEKMFKQYDAGKD HHHHHHHHHHHCCCC	44.44	22902405
107	Acetylation	FKQYDAGKDGFIDLM HHHHHCCCCCHHHHH	57.30	22902405
122	Acetylation	ELKLMMEKLGAPQTH HHHHHHHHHCCCCCH	34.03	22902405
158	Ubiquitination	EFLLIFRKAAAGELQ HHHHHHHHHHCCCCC	31.46	-
203	Phosphorylation	KVQAINVSSRFEEEI HHHHHCCCHHHHHHH	16.00	27097102
204	Phosphorylation	VQAINVSSRFEEEIK HHHHCCCHHHHHHHH	36.38	27097102
232	Acetylation	KQRKAAFKELQSTFK HHHHHHHHHHHHHCC	53.43	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
73	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFHD2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFHD2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of EFHD2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.