EFGM1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFGM1_ARATH
• UniProt AC: Q9C641
• Protein Name: Elongation factor G-1, mitochondrial
• Gene Name: MEFG1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 754
• Subcellular Localization: Mitochondrion .
• Protein Description: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome..
• Protein Sequence: MARFPTSPAPNRLLRLFSSNKRSSSPTAALLTGDFQLIRHFSAGTAARVAKDEKEPWWKESMDKLRNIGISAHIDSGKTTLTERVLFYTGRIHEIHEVRGRDGVGAKMDSMDLEREKGITIQSAATYCTWKDYKVNIIDTPGHVDFTIEVERALRVLDGAILVLCSVGGVQSQSITVDRQMRRYEVPRVAFINKLDRMGADPWKVLNQARAKLRHHSAAVQVPIGLEENFQGLIDLIHVKAYFFHGSSGENVVAGDIPADMEGLVAEKRRELIETVSEVDDVLAEKFLNDEPVSASELEEAIRRATIAQTFVPVFMGSAFKNKGVQPLLDGVVSFLPSPNEVNNYALDQNNNEERVTLTGSPDGPLVALAFKLEEGRFGQLTYLRVYEGVIKKGDFIINVNTGKRIKVPRLVRMHSNDMEDIQEAHAGQIVAVFGIECASGDTFTDGSVKYTMTSMNVPEPVMSLAVQPVSKDSGGQFSKALNRFQKEDPTFRVGLDPESGQTIISGMGELHLDIYVERMRREYKVDATVGKPRVNFRETITQRAEFDYLHKKQSGGAGQYGRVTGYVEPLPPGSKEKFEFENMIVGQAIPSGFIPAIEKGFKEAANSGSLIGHPVENLRIVLTDGASHAVDSSELAFKMAAIYAFRLCYTAARPVILEPVMLVELKVPTEFQGTVAGDINKRKGIIVGNDQEGDDSVITANVPLNNMFGYSTSLRSMTQGKGEFTMEYKEHSAVSNEVQAQLVNAYSASKATE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
174	Phosphorylation	VGGVQSQSITVDRQM CCCCCCCEEECCHHH		28011693
176	Phosphorylation	GVQSQSITVDRQMRR CCCCCEEECCHHHHH		28011693
194	Acetylation	PRVAFINKLDRMGAD CHHHHHHHHHHCCCC		24727099
382	Phosphorylation	EGRFGQLTYLRVYEG CCCCCCEEEEEEEEE		24894044
402	Phosphorylation	DFIINVNTGKRIKVP CEEEECCCCCCEECC		23328941
542	Phosphorylation	VNFRETITQRAEFDY CCHHHHHHHHHHHHH		22074104
549	Phosphorylation	TQRAEFDYLHKKQSG HHHHHHHHEECCCCC		22074104
624	Phosphorylation	ENLRIVLTDGASHAV CCEEEEECCCCCCCC		19880383
628	Phosphorylation	IVLTDGASHAVDSSE EEECCCCCCCCCHHH		19880383
633	Phosphorylation	GASHAVDSSELAFKM CCCCCCCHHHHHHHH		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFGM1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFGM1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFGM1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of EFGM1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.