EFGC_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFGC_ARATH
• UniProt AC: Q9SI75
• Protein Name: Elongation factor G, chloroplastic {ECO:0000255|HAMAP-Rule:MF_03063}
• Gene Name: CPEFG
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 783
• Subcellular Localization: Plastid, chloroplast .
• Protein Description: Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Required for the eoplasts redifferentiation into chloroplasts after germination..
• Protein Sequence: MAADALRISSSSSGSLVCNLNGSQRRPVLLPLSHRATFLGLPPRASSSSISSSIPQFLGTSRIGLGSSKLSQKKKQFSVFAAAEAEAKRAVPLKDYRNIGIMAHIDAGKTTTTERILYYTGRNYKIGEVHEGTATMDWMEQEQERGITITSAATTTFWDKHRINIIDTPGHVDFTLEVERALRVLDGAICLFDSVAGVEPQSETVWRQADKYGVPRICFVNKMDRLGANFFRTRDMIVTNLGAKPLVLQIPIGAEDVFKGVVDLVRMKAIVWSGEELGAKFSYEDIPEDLEDLAQEYRAAMMELIVDLDDEVMENYLEGVEPDEATVKRLVRKGTITGKFVPILCGSAFKNKGVQPLLDAVVDYLPSPVEVPPMNGTDPENPEITIIRKPDDDEPFAGLAFKIMSDPFVGSLTFVRVYSGKISAGSYVLNANKGKKERIGRLLEMHANSREDVKVALTGDIIALAGLKDTITGETLSDPENPVVLERMDFPDPVIKVAIEPKTKADIDKMATGLIKLAQEDPSFHFSRDEEMNQTVIEGMGELHLEIIVDRLKREFKVEANVGAPQVNYRESISKIAEVKYTHKKQSGGQGQFADITVRFEPLEAGSGYEFKSEIKGGAVPREYIPGVMKGLEECMSTGVLAGFPVVDVRACLVDGSYHDVDSSVLAFQLAARGAFREGMRKAGPRMLEPIMRVEVVTPEEHLGDVIGDLNSRRGQINSFGDKPGGLKVVDSLVPLAEMFQYVSTLRGMTKGRASYTMQLAKFDVVPQHIQNQLSSKDQEVAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
510	Sulfoxidation	TKADIDKMATGLIKL CHHHHHHHHHHHHHH		25693801
629	Sulfoxidation	REYIPGVMKGLEECM HHHCCHHHHHHHHHH		25693801
758	Sulfoxidation	KGRASYTMQLAKFDV CCCCEEEEEECHHCC		25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFGC_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFGC_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFGC_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of EFGC_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.