EFCB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFCB3_HUMAN
• UniProt AC: Q8N7B9
• Protein Name: EF-hand calcium-binding domain-containing protein 3
• Gene Name: EFCAB3
• Organism: Homo sapiens (Human).
• Sequence Length: 438
• Protein Sequence: MAVSEIKPKLKLNPLTKVPISHNKRDRDLPGSLQCQLQHKEKKLSASQMAAFQDAYNFFYKDKTGCIDFHGLMCTVAKLGMNLTKHDVYNELKCADIDRDGKVNFSDFIKVLTDKNLFLKAVVPEKETCLDLAGNPGILLFEILSRLLETSALPRKSIIEIVSYFQRKFQHTGPGMLWSPYTMGYGKRTLKPDICTPPSSSMAAFANAARIAIMKEKDLFKFLEELKRCNSGSDSPYSKIPIFPLFPNVDGVVMGKPFKDMQKLEMLRIKEPLHFFEDYFFHKRDWKTQAANIKSMDPASGYSNNIFTIDQMLKKKQTCTVADATAIKQHVKRATDTYNLGIALEHRKEMLNLWQKIRGDLIGMDSRNESFYDTFSTYTWSWNVCQELLSPKDLRLYDAYVNRNSSHNSRSSSSSDTSECYTDSGRKRKRKGLKGFQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAVSEIKPKLK ----CCHHHCCCCCC	24.86	18187866
9 (in isoform 2)	Phosphorylation	-	53.93	25999147
32	Phosphorylation	RDRDLPGSLQCQLQH CCCCCCCCHHHHHHH	17.21	30622161
145	Phosphorylation	ILLFEILSRLLETSA HHHHHHHHHHHHCCC	26.92	24719451
151	Phosphorylation	LSRLLETSALPRKSI HHHHHHCCCCCHHHH	20.59	24719451
157	Phosphorylation	TSALPRKSIIEIVSY CCCCCHHHHHHHHHH	30.03	27174698
163	Phosphorylation	KSIIEIVSYFQRKFQ HHHHHHHHHHHHHCC	26.37	27174698
164	Phosphorylation	SIIEIVSYFQRKFQH HHHHHHHHHHHHCCC	7.88	27174698
189	Phosphorylation	TMGYGKRTLKPDICT CCCCCCCCCCCCCCC	42.49	24719451
196	Phosphorylation	TLKPDICTPPSSSMA CCCCCCCCCCCHHHH	38.27	24719451
199	Phosphorylation	PDICTPPSSSMAAFA CCCCCCCCHHHHHHH	35.93	25693802
200	Phosphorylation	DICTPPSSSMAAFAN CCCCCCCHHHHHHHH	29.88	25693802
201	Phosphorylation	ICTPPSSSMAAFANA CCCCCCHHHHHHHHH	19.44	25693802
241	Phosphorylation	DSPYSKIPIFPLFPN CCCCCCCCCCCCCCC	26.38	24719451
248	Phosphorylation	PIFPLFPNVDGVVMG CCCCCCCCCCEEEEC	36.86	24719451
279	Phosphorylation	PLHFFEDYFFHKRDW CHHHHHHHHHHCCCH	10.84	30622161
300	Phosphorylation	IKSMDPASGYSNNIF CCCCCCCCCCCCCCE	43.59	-
372	Phosphorylation	DSRNESFYDTFSTYT CCCCCCHHHHCHHHE	24.29	-
390	Phosphorylation	NVCQELLSPKDLRLY HHHHHHCCHHHHHHH	42.39	24719451
406	Phosphorylation	AYVNRNSSHNSRSSS HHCCCCCCCCCCCCC	30.18	16964243
409	Phosphorylation	NRNSSHNSRSSSSSD CCCCCCCCCCCCCCC	28.28	16964243
418	Phosphorylation	SSSSSDTSECYTDSG CCCCCCCHHCCCCCC	30.57	-
422	Phosphorylation	SDTSECYTDSGRKRK CCCHHCCCCCCHHHC	35.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFCB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFCB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFCB3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EFCB3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, AND MASSSPECTROMETRY.
PubMed: 18187866