EDF1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDF1_RAT
• UniProt AC: P69736
• Protein Name: Endothelial differentiation-related factor 1
• Gene Name: Edf1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 148
• Subcellular Localization: Cytoplasm. Nucleus. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin (By similarity). Localized mainly in soma and dendritic processes of neurons.
• Protein Description: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity)..
• Protein Sequence: MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQRGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAESDWDTV ------CCCCCCCCC	25.63	-
4	Phosphorylation	----MAESDWDTVTV ----CCCCCCCCCHH	34.17	-
25	Methylation	TAAQAKSKQAILAAQ CHHHHHHHHHHHHHH	42.94	-
50	Acetylation	KWAAGQNKQHSITKN HHHCCCCCCCCCCCC	41.31	22902405
53	Phosphorylation	AGQNKQHSITKNTAK CCCCCCCCCCCCCHH	29.47	29779826
55	Phosphorylation	QNKQHSITKNTAKLD CCCCCCCCCCCHHCC	22.66	22673903
60	Acetylation	SITKNTAKLDRETEE CCCCCCHHCCHHHHH	49.21	22902405
79	Acetylation	RVTLEVGKVIQRGRQ CCHHHHHHHHHHHHC	41.14	22902405
79	Ubiquitination	RVTLEVGKVIQRGRQ CCHHHHHHHHHHHHC	41.14	-
93	Acetylation	QSKGLTQKDLATKIN CCCCCCHHHHHHHHC	49.85	22902405
93	Ubiquitination	QSKGLTQKDLATKIN CCCCCCHHHHHHHHC	49.85	-
98	Acetylation	TQKDLATKINEKPQV CHHHHHHHHCCCCCE	37.62	22902405
98	Ubiquitination	TQKDLATKINEKPQV CHHHHHHHHCCCCCE	37.62	-
102	Acetylation	LATKINEKPQVIADY HHHHHCCCCCEEEEC	35.94	22902405
123	Acetylation	PNNQVLGKIERAIGL CCCCHHHHHHHHHCC	36.91	22902405
131	Acetylation	IERAIGLKLRGKDIG HHHHHCCEECCCCCC	30.81	22902405
135	Acetylation	IGLKLRGKDIGKPIE HCCEECCCCCCCCCC	39.47	22902405
139	Acetylation	LRGKDIGKPIEKGPK ECCCCCCCCCCCCCC	43.06	22902405
143	Acetylation	DIGKPIEKGPKAK-- CCCCCCCCCCCCC--	79.72	22902405
143	Ubiquitination	DIGKPIEKGPKAK-- CCCCCCCCCCCCC--	79.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDF1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDF1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDF1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of EDF1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.