EDEM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDEM1_MOUSE
• UniProt AC: Q925U4
• Protein Name: ER degradation-enhancing alpha-mannosidase-like protein 1
• Gene Name: Edem1
• Organism: Mus musculus (Mouse).
• Sequence Length: 652
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein .
• Protein Description: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2..
• Protein Sequence: MQWRALVLGLVLLRLGLHAVLWLVFGLGPSMGFYQRFPLSFGFQRLRDPDGSGPVGPPGGPAWLHRPRRGTEGRLETPPEPGPTPGPGVCGPAHWGYALGGGGCGPDEYERRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIYCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIEDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQSYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSKEDRMESFFLSETCKYLYLLFDEENPVHKSGTRYMFTTEGHIISVDKRLRELPWKEFFSEDGERDQEEKFVHRPKSQELRVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Ubiquitination	TPPEPGPTPGPGVCG CCCCCCCCCCCCCCC	46.95	27667366
176	N-linked_Glycosylation	NINDVLGNYSLTLVD CHHHHCCCCCEEHHH	21.04	-
193	N-linked_Glycosylation	DTLAIMGNSSEFQKA HHHHHCCCCHHHHHH	25.61	-
274	Ubiquitination	LPAFENTKTGIPYPR HHHHCCCCCCCCCCC	57.23	27667366
294	N-linked_Glycosylation	GVPPDSNNETCTAGA CCCCCCCCCCCCCCH	50.32	-
337	N-linked_Glycosylation	ALWNLRSNDTGLLGN HHHHCCCCCCCCCCC	44.42	-
505	Phosphorylation	QATKNPFYLHVGMDI HHHCCCCEEECCHHH	9.35	28059163
520	Phosphorylation	LQSLEKYTKVKCGYA HHHHHHHHCCCCCEE	40.19	28059163
634	Phosphorylation	VPDERRYSLPLKSIY CCCCCCCCCCHHHHH	23.00	27600695
638	Ubiquitination	RRYSLPLKSIYMRQI CCCCCCHHHHHHHHH	32.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDEM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDEM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDEM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SE1L1_HUMAN	SEL1L	physical	22905195

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.