ECSCR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ECSCR_HUMAN
• UniProt AC: Q19T08
• Protein Name: Endothelial cell-specific chemotaxis regulator
• Gene Name: ECSCR
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cytoplasm.
• Protein Description: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2..
• Protein Sequence: MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	LLFRGHNSQPTMTQT HHHCCCCCCCCEEEE	31.68	22210691
34	Phosphorylation	TMTQTSSSQGGLGGL CEEEECCCCCCCCCE	32.39	22210691
50	Phosphorylation	LTTEPVSSNPGYIPS EECCCCCCCCCCCCC	47.48	22210691
54	Phosphorylation	PVSSNPGYIPSSEAN CCCCCCCCCCCCCCC	15.77	22210691
68	O-linked_Glycosylation	NRPSHLSSTGTPGAG CCCCCCCCCCCCCCC	36.90	OGP
69	O-linked_Glycosylation	RPSHLSSTGTPGAGV CCCCCCCCCCCCCCC	41.52	OGP
71	O-linked_Glycosylation	SHLSSTGTPGAGVPS CCCCCCCCCCCCCCC	20.73	OGP
89	Phosphorylation	DGGTSRDTFQTVPPN CCCCCCCCCCCCCCC	19.28	29978859
92	Phosphorylation	TSRDTFQTVPPNSTT CCCCCCCCCCCCCCE	30.68	29978859
97	Phosphorylation	FQTVPPNSTTMSLSM CCCCCCCCCEEEEEE	30.91	29978859
98	Phosphorylation	QTVPPNSTTMSLSMR CCCCCCCCEEEEEEC	32.91	29978859
99	Phosphorylation	TVPPNSTTMSLSMRE CCCCCCCEEEEEECC	12.46	29978859
101	Phosphorylation	PPNSTTMSLSMREDA CCCCCEEEEEECCCC	18.39	29978859
103	Phosphorylation	NSTTMSLSMREDATI CCCEEEEEECCCCEE	14.42	29978859
165	Phosphorylation	EDPQKPGSSGLSESC CCCCCCCCCCCCCCC	29.75	24501219
171	Phosphorylation	GSSGLSESCSTANGE CCCCCCCCCCCCCCC	15.25	-
174	Phosphorylation	GLSESCSTANGEKDS CCCCCCCCCCCCCCE	28.59	-
181	Phosphorylation	TANGEKDSITLISMK CCCCCCCEEEEEECE	28.65	-
186	Phosphorylation	KDSITLISMKNINMN CCEEEEEECEEECCC	27.15	28857561
198	Phosphorylation	NMNNGKQSLSAEKVL CCCCCCCCCCHHHCC	27.98	-
200	Phosphorylation	NNGKQSLSAEKVL-- CCCCCCCCHHHCC--	39.36	26091039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ECSCR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ECSCR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ECSCR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA7_HUMAN	PSMA7	physical	19416853

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.