ECHA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ECHA_RAT
• UniProt AC: Q64428
• Protein Name: Trifunctional enzyme subunit alpha, mitochondrial
• Gene Name: Hadha
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 763
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Bifunctional subunit..
• Protein Sequence: MVASRAIGSLSRFSAFRILRSRGCICHSFTTSSALLSRTHINYGVKGDVAVIRINSPNSKVNTLNKEVQSEFVEVMNEIWANDQIRSAVLISSKPGCFVAGADINMLASCTTPQEAARISQEGQKMFEKLEKSPKPVVAAISGSCLGGGLELAIACQYRIATKDRKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQLVDPLGPGIKSPEERTIEYLEEVAVNFAKGLADRKVSAKQSKGLMEKLTSYAMTIPFVRQQVYKTVEEKVKKQTKGLYPAPLKIIDAVKTGLEQGNDAGYLAESEKFGELALTKESKALMGLYNGQVLCKKNKFGAPQKTVQQLAILGAGLMGAGIAQVSVDKGLKTLLKDTTVTGLGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLAVKHKVLKEVESVTPEHCIFASNTSALPINQIAAVSQRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDALTTGFGFPVGAATLADEVGIDVAQHVAEDLGKAFGERFGGGSVELLKLMVSKGFLGRKSGKGFYIYQSGSKNKNLNSEIDNILVNLRLPAKPEVSSDEDIQYRVITRFVNEAVLCLQEGILATPEEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYESAYGTQFTPCQLLRDLANNSSKKFYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Acetylation	THINYGVKGDVAVIR CCCCCCCCCCEEEEE	45.06	22902405
46	Succinylation	THINYGVKGDVAVIR CCCCCCCCCCEEEEE	45.06	-
46	Succinylation	THINYGVKGDVAVIR CCCCCCCCCCEEEEE	45.06	-
59	Phosphorylation	IRINSPNSKVNTLNK EEECCCCHHHCCCCH	41.17	23991683
60	Acetylation	RINSPNSKVNTLNKE EECCCCHHHCCCCHH	46.26	25786129
60	Succinylation	RINSPNSKVNTLNKE EECCCCHHHCCCCHH	46.26	-
60	Succinylation	RINSPNSKVNTLNKE EECCCCHHHCCCCHH	46.26	-
125	Acetylation	RISQEGQKMFEKLEK HHCHHHHHHHHHHHC	57.31	22902405
129	Acetylation	EGQKMFEKLEKSPKP HHHHHHHHHHCCCCC	51.16	22902405
132	Acetylation	KMFEKLEKSPKPVVA HHHHHHHCCCCCEEE	80.59	26302492
166	Acetylation	RIATKDRKTVLGVPE EECCCCCCCCCCCCH	53.79	22902405
166	Succinylation	RIATKDRKTVLGVPE EECCCCCCCCCCCCH	53.79	-
166	Succinylation	RIATKDRKTVLGVPE EECCCCCCCCCCCCH	53.79	26843850
185	O-linked_Glycosylation	ILPGAGGTQRLPKMV CCCCCCCCCCCCHHH	15.03	27213235
213	Succinylation	NIRADRAKKMGLVDQ CCCHHHHHHCCHHHH	44.16	-
213	Succinylation	NIRADRAKKMGLVDQ CCCHHHHHHCCHHHH	44.16	-
214	Acetylation	IRADRAKKMGLVDQL CCHHHHHHCCHHHHH	36.90	22902405
214	Succinylation	IRADRAKKMGLVDQL CCHHHHHHCCHHHHH	36.90	-
214	Succinylation	IRADRAKKMGLVDQL CCHHHHHHCCHHHHH	36.90	26843850
230	Succinylation	DPLGPGIKSPEERTI CCCCCCCCCHHHHHH	66.91	-
230	Succinylation	DPLGPGIKSPEERTI CCCCCCCCCHHHHHH	66.91	-
231	Phosphorylation	PLGPGIKSPEERTIE CCCCCCCCHHHHHHH	35.31	23991683
249	Acetylation	EVAVNFAKGLADRKV HHHHHHHHHHHCCCC	50.77	22902405
249	Succinylation	EVAVNFAKGLADRKV HHHHHHHHHHHCCCC	50.77	-
249	Succinylation	EVAVNFAKGLADRKV HHHHHHHHHHHCCCC	50.77	-
269	O-linked_Glycosylation	KGLMEKLTSYAMTIP CCHHHHHHHHHHHHH	30.66	27213235
270	O-linked_Glycosylation	GLMEKLTSYAMTIPF CHHHHHHHHHHHHHH	22.72	27213235
284	Acetylation	FVRQQVYKTVEEKVK HHHHHHHHHHHHHHH	47.43	22902405
289	Acetylation	VYKTVEEKVKKQTKG HHHHHHHHHHHHCCC	45.94	22902405
291	Acetylation	KTVEEKVKKQTKGLY HHHHHHHHHHCCCCC	50.67	26302492
295	Acetylation	EKVKKQTKGLYPAPL HHHHHHCCCCCCCCH	44.41	22902405
303	Acetylation	GLYPAPLKIIDAVKT CCCCCCHHHHHHHHH	36.23	22902405
303	Succinylation	GLYPAPLKIIDAVKT CCCCCCHHHHHHHHH	36.23	-
303	Succinylation	GLYPAPLKIIDAVKT CCCCCCHHHHHHHHH	36.23	-
326	Acetylation	GYLAESEKFGELALT CCEECHHHHCCCCCC	68.87	26302492
326	Succinylation	GYLAESEKFGELALT CCEECHHHHCCCCCC	68.87	-
326	Succinylation	GYLAESEKFGELALT CCEECHHHHCCCCCC	68.87	-
334	Acetylation	FGELALTKESKALMG HCCCCCCHHHHHHHH	61.92	26302492
334	Succinylation	FGELALTKESKALMG HCCCCCCHHHHHHHH	61.92	-
334	Succinylation	FGELALTKESKALMG HCCCCCCHHHHHHHH	61.92	-
343	Phosphorylation	SKALMGLYNGQVLCK HHHHHHHHCCEEEEE	16.12	-
350	Acetylation	YNGQVLCKKNKFGAP HCCEEEEECCCCCCC	56.04	-
350	Succinylation	YNGQVLCKKNKFGAP HCCEEEEECCCCCCC	56.04	-
350	Succinylation	YNGQVLCKKNKFGAP HCCEEEEECCCCCCC	56.04	-
351	Acetylation	NGQVLCKKNKFGAPQ CCEEEEECCCCCCCH	65.46	22902405
353	Acetylation	QVLCKKNKFGAPQKT EEEEECCCCCCCHHH	54.80	22902405
386	Acetylation	VSVDKGLKTLLKDTT EECCCHHHHHHHCCC	45.88	22902405
390	Acetylation	KGLKTLLKDTTVTGL CHHHHHHHCCCCCCC	57.02	22902405
393	Phosphorylation	KTLLKDTTVTGLGRG HHHHHCCCCCCCCHH	26.63	22673903
395	Phosphorylation	LLKDTTVTGLGRGQQ HHHCCCCCCCCHHHH	25.29	23991683
399	Methylation	TTVTGLGRGQQQVFK CCCCCCCHHHHHHHH	44.80	-
406	Acetylation	RGQQQVFKGLNDKVK HHHHHHHHCCCHHHH	64.73	25786129
406	Succinylation	RGQQQVFKGLNDKVK HHHHHHHHCCCHHHH	64.73	-
406	Succinylation	RGQQQVFKGLNDKVK HHHHHHHHCCCHHHH	64.73	26843850
411	Acetylation	VFKGLNDKVKKKALT HHHCCCHHHHHHHCH	55.68	22902405
411	Succinylation	VFKGLNDKVKKKALT HHHCCCHHHHHHHCH	55.68	-
411	Succinylation	VFKGLNDKVKKKALT HHHCCCHHHHHHHCH	55.68	-
413	Acetylation	KGLNDKVKKKALTSF HCCCHHHHHHHCHHH	55.06	26302492
415	Acetylation	LNDKVKKKALTSFER CCHHHHHHHCHHHHH	42.80	22902405
415	Succinylation	LNDKVKKKALTSFER CCHHHHHHHCHHHHH	42.80	-
415	Succinylation	LNDKVKKKALTSFER CCHHHHHHHCHHHHH	42.80	26843850
418	Phosphorylation	KVKKKALTSFERDSI HHHHHHCHHHHHHHH	35.91	30181290
419	Phosphorylation	VKKKALTSFERDSIF HHHHHCHHHHHHHHH	26.43	23991683
424	Phosphorylation	LTSFERDSIFSNLIG CHHHHHHHHHHHHHH	31.58	23991683
427	Phosphorylation	FERDSIFSNLIGQLD HHHHHHHHHHHHHCC	29.11	23991683
436	Acetylation	LIGQLDYKGFEKADM HHHHCCCCCHHHHHH	57.71	22902405
436	Succinylation	LIGQLDYKGFEKADM HHHHCCCCCHHHHHH	57.71	-
436	Succinylation	LIGQLDYKGFEKADM HHHHCCCCCHHHHHH	57.71	-
440	Acetylation	LDYKGFEKADMVIEA CCCCCHHHHHHHHHH	47.64	25786129
440	Succinylation	LDYKGFEKADMVIEA CCCCCHHHHHHHHHH	47.64	-
440	Succinylation	LDYKGFEKADMVIEA CCCCCHHHHHHHHHH	47.64	-
455	Acetylation	VFEDLAVKHKVLKEV HHHHHHHHHHHHHHC	31.91	26302492
457	Acetylation	EDLAVKHKVLKEVES HHHHHHHHHHHHCCC	43.47	26302492
460	Acetylation	AVKHKVLKEVESVTP HHHHHHHHHCCCCCH	63.80	22902405
460	Succinylation	AVKHKVLKEVESVTP HHHHHHHHHCCCCCH	63.80	-
460	Succinylation	AVKHKVLKEVESVTP HHHHHHHHHCCCCCH	63.80	-
493	Acetylation	AVSQRPEKVIGMHYF HHHCCCHHEECEEEC	41.66	26302492
505	Acetylation	HYFSPVDKMQLLEII EECCCCCHHHEEEEH	28.87	25786129
505	Succinylation	HYFSPVDKMQLLEII EECCCCCHHHEEEEH	28.87	-
505	Succinylation	HYFSPVDKMQLLEII EECCCCCHHHEEEEH	28.87	-
516	Acetylation	LEIITTDKTSKDTTA EEEHHCCCCCCCCCC	53.24	26302492
519	Acetylation	ITTDKTSKDTTASAV HHCCCCCCCCCCHHE	65.41	22902405
519	Succinylation	ITTDKTSKDTTASAV HHCCCCCCCCCCHHE	65.41	-
519	Succinylation	ITTDKTSKDTTASAV HHCCCCCCCCCCHHE	65.41	-
521	O-linked_Glycosylation	TDKTSKDTTASAVAV CCCCCCCCCCHHEEE	28.18	27213235
524	O-linked_Glycosylation	TSKDTTASAVAVGLK CCCCCCCHHEEEEEC	22.60	27213235
531	Acetylation	SAVAVGLKQGKVIIV HHEEEEECCCEEEEE	51.59	25786129
531	Succinylation	SAVAVGLKQGKVIIV HHEEEEECCCEEEEE	51.59	26843850
540	Acetylation	GKVIIVVKDGPGFYT CEEEEEEECCCCCCH	46.18	22902405
569	Acetylation	LQEGVDPKKLDALTT HHCCCCHHHCHHHHC	62.60	22902405
569	Succinylation	LQEGVDPKKLDALTT HHCCCCHHHCHHHHC	62.60	-
569	Succinylation	LQEGVDPKKLDALTT HHCCCCHHHCHHHHC	62.60	-
615	O-linked_Glycosylation	GERFGGGSVELLKLM HHHHCCCHHHHHHHH	18.72	27213235
620	Succinylation	GGSVELLKLMVSKGF CCHHHHHHHHHHCCC	47.35	-
620	Succinylation	GGSVELLKLMVSKGF CCHHHHHHHHHHCCC	47.35	-
625	Acetylation	LLKLMVSKGFLGRKS HHHHHHHCCCCCCCC	42.12	22902405
634	Succinylation	FLGRKSGKGFYIYQS CCCCCCCCCEEEEEC	53.60	-
634	Succinylation	FLGRKSGKGFYIYQS CCCCCCCCCEEEEEC	53.60	-
641	Phosphorylation	KGFYIYQSGSKNKNL CCEEEEECCCCCCCC	28.23	23991683
643	Phosphorylation	FYIYQSGSKNKNLNS EEEEECCCCCCCCCH	38.00	23991683
644	Acetylation	YIYQSGSKNKNLNSE EEEECCCCCCCCCHH	75.39	25786129
644	Succinylation	YIYQSGSKNKNLNSE EEEECCCCCCCCCHH	75.39	-
644	Succinylation	YIYQSGSKNKNLNSE EEEECCCCCCCCCHH	75.39	-
646	Acetylation	YQSGSKNKNLNSEID EECCCCCCCCCHHHC	67.55	22902405
646	Succinylation	YQSGSKNKNLNSEID EECCCCCCCCCHHHC	67.55	-
646	Succinylation	YQSGSKNKNLNSEID EECCCCCCCCCHHHC	67.55	-
650	Phosphorylation	SKNKNLNSEIDNILV CCCCCCCHHHCEEHH	38.81	23991683
664	Acetylation	VNLRLPAKPEVSSDE HHCCCCCCCCCCCCC	39.51	22902405
664	Succinylation	VNLRLPAKPEVSSDE HHCCCCCCCCCCCCC	39.51	-
664	Succinylation	VNLRLPAKPEVSSDE HHCCCCCCCCCCCCC	39.51	-
668	O-linked_Glycosylation	LPAKPEVSSDEDIQY CCCCCCCCCCCCHHH	30.34	27213235
668	Phosphorylation	LPAKPEVSSDEDIQY CCCCCCCCCCCCHHH	30.34	23991683
669	Phosphorylation	PAKPEVSSDEDIQYR CCCCCCCCCCCHHHH	50.63	23991683
724	Phosphorylation	PFRFVDLYGAQKVVD CEEEEHHHCHHHHHH	13.12	28689409
728	Acetylation	VDLYGAQKVVDRLRK EHHHCHHHHHHHHHH	43.63	22902405
728	Succinylation	VDLYGAQKVVDRLRK EHHHCHHHHHHHHHH	43.63	-
728	Succinylation	VDLYGAQKVVDRLRK EHHHCHHHHHHHHHH	43.63	26843850
735	Acetylation	KVVDRLRKYESAYGT HHHHHHHHHHHHHCC	58.94	22902405
735	Succinylation	KVVDRLRKYESAYGT HHHHHHHHHHHHHCC	58.94	26843850
759	Acetylation	DLANNSSKKFYQ--- HHHHCCCCCCCC---	46.88	-
759	Succinylation	DLANNSSKKFYQ--- HHHHCCCCCCCC---	46.88	-
759	Succinylation	DLANNSSKKFYQ--- HHHHCCCCCCCC---	46.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ECHA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ECHA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ECHA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ECHA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.